Rav Mosshe Isserles, more famously known as the 'Rema', is most well known for his work on the Shulchan Aruch, which has been included in all editions of Shulchan Aruch since 1578.
But it would take another century and then some for his commentary on the Tur, the Darkei Moshe, to be printed. Until then it circulated only in manuscript form.
The Rebbe's library owns several such manuscripts.
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