What if we could map the quiet, hidden changes in brain wiring that predict who’s at risk for memory loss? In this episode, we explore a groundbreaking study that analyzed over 9,000 cognitive sessions from 4,467 participants, uncovering how subtle changes in the brain’s white matter—especially in the limbic system—signal cognitive decline.
Using harmonized diffusion MRI from nine major cohorts, the team found that free water (FW) in tracts like the cingulum and fornix was a powerful indicator of both baseline memory and future decline. These white matter markers interacted with other Alzheimer's disease biomarkers, including APOE ε4, hippocampal volume, and amyloid levels, revealing a complex biological web behind aging and dementia.
This summary was AI-generated and reviewed by a contributing author. Interpretations reflect individual perspectives and not official statements from all authors or affiliated institutions.
Popular Podcasts
Stuff You Should Know
If you've ever wanted to know about champagne, satanism, the Stonewall Uprising, chaos theory, LSD, El Nino, true crime and Rosa Parks, then look no further. Josh and Chuck have you covered.
Crime Junkie
Does hearing about a true crime case always leave you scouring the internet for the truth behind the story? Dive into your next mystery with Crime Junkie. Every Monday, join your host Ashley Flowers as she unravels all the details of infamous and underreported true crime cases with her best friend Brit Prawat. From cold cases to missing persons and heroes in our community who seek justice, Crime Junkie is your destination for theories and stories you won’t hear anywhere else. Whether you're a seasoned true crime enthusiast or new to the genre, you'll find yourself on the edge of your seat awaiting a new episode every Monday. If you can never get enough true crime... Congratulations, you’ve found your people. Follow to join a community of Crime Junkies! Crime Junkie is presented by audiochuck Media Company.
24/7 News: The Latest
The latest news in 4 minutes updated every hour, every day.