Fuzzy science” abounds in the world, and even luminaries fall into its trap sometimes. This review clarifies the mis-explanations of important concepts in lipid science that were discussed in Peter Attia’s podcast. The interview with Dr. Thomas Dayspring resulted in a 7 hour series that promised a deep dive into cholesterol and lipoproteins. Lipid science is a complex and ever-evolving field. Understanding some of the basic tenets of the field helps us traverse more complicated topics. The intention of this review is to help clarify the important points Dr. Dayspring made and to open up the scope of the discussion by examining less considered aspects of cholesterol, lipoproteins and their functions. The deep dive into the topic by Drs. Attia and Dayspring was indeed much needed and appreciated and this review acts merely as supplementary commentary or footnotes to the discussion. Since Attia and Dayspring devoted an impressive 7 hours to their discussion, the 2 hour length in this episode respects the time and effort that went into their series by attending to their points in detail. Let me know your thoughts in the comments. What questions do you have from Dr. Dayspring’s interview?
Time stamps: 00:00 Intro
05:11 Criteria for review
06:53 Aligning with their intention
09:29 Feynman's scientific principles
11:28 Phospholipids
18:46 Lipid Rafts
30:54 TD: "All cells make cholesterol."
45:28 The Rare Exceptions 50:45 Lipoproteins & cholesterol in artery walls
1:05:59 Pools of Cholesterol
1:09:50 Lipoprotein density
1:12:23 How apoproteins are bound
1:15:04 Statins & liver selectivity
1:21:05 Cholesterol functions & metabolism
1:31:02 HDL 1:34:11 RBC membrane cholesterol
1:36:59 Lipoprotein lineages
1:40:48 ApoE
1:50:40 Cholesterol's function in lipoproteins
1:59:55 Unregulated apoB
2:02:23 Conclusion
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