Dr. Xiao Xiong earned his PhD degree in Cellular and Molecular Medicine from University of Ottawa. He studied the tumour-suppressive function and mechanism of a channel protein, in rhabdomyosarcoma, and published 8 high-impact papers of which he first-authored 3 of them. Upon completion of his Ph.D., he took on a pot Doc after becoming interested in oncolytic viruses and immunotherapy. He started working on bioengineering Reovirus, a benign gastro-intestinal virus, for use in cancer therapy and an oral vaccine for infectious diseases. In this episode we discuss the inner workings of viruses, how they replicate and overwhelm host machinery, how they evade the immune system, and discuss the basis of vaccines and their subsequent development. To learn more about the podcast, check my website below: https://whereknowledgestemsfrom.com/ Sound track:
https://pixabay.com/music/drama-scene-ominous-tension-157906/
Dr. Xiao Xiang Publications:
https://scholar.google.com/citations?user=L-bS7H8AAAAJ&hl=en
If you are interested in specific parts of this episode, here are the timestamps of different chapters:
(00:00) Intro
(01:29) Research Background
(07:03) What Are Viruses
(09:13) Are Viruses Alive
(10:39) Viral Makeup
(13:53) Virus Types & Immune Evasion
(20:15) Antivirals
(24:41) Infectiousness, Lethality, Resistance
(40:33) Dormant Viruses
(43:05) Viral Replication & Detection
(54:24) Vaccine History, Types, & Efficacy
(1:11:20) Injected Vs Oral Vaccines
(1:20:53) Outro
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