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Top 5 Healthcare Headlines for March 23-30, 2025:
Zetomipzomib Shows Promise for Autoimmune Hepatitis in Phase 2a PORTOLA Trial
Zetomipzomib demonstrated steroid-sparing biochemical remissions in refractory autoimmune hepatitis patients, aligning with AASLD treatment guidelines in the Phase 2a PORTOLA trial.
Solriamfetol Significantly Reduces ADHD Symptoms in Axsome’s Phase 3 Trial
Solriamfetol met its primary endpoint in the Phase 3 FOCUS trial, significantly improving ADHD symptoms, with a higher proportion of patients achieving clinical response compared to placebo.
Sozinibercept for Wet AMD Misses Primary Endpoint in Phase 3 COAST Trial
Sozinibercept combined with aflibercept failed to meet the primary endpoint for visual acuity improvement in wet AMD, showing no added benefit over aflibercept monotherapy.
FDA Approves Gepotidacin (Blujepa) for Uncomplicated UTI
The FDA approved gepotidacin for uncomplicated urinary tract infections based on Phase 3 trials demonstrating non-inferiority to nitrofurantoin in female adults and adolescents.
FDA Issues CRL for Etripamil Nasal Spray (Cardamyst) in PSVT
The FDA issued a Complete Response Letter for etripamil nasal spray, citing manufacturing and control issues while confirming no concerns regarding its clinical safety or efficacy.
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