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March 12, 2026 27 mins
People are reporting a very strange phenomenon: They say that when their nipples get touched, they feel this weird sinking feeling. People describe it like being homesick, or hung over. Some feel anguish and despair, others call it dread. The condition has a name: "Sad Nipple Syndrome." But how could just touching a nipple set off all of these feelings?? To get to the bottom of this booby baffler, we go deep into the mysteries of anatomy and through a world of hormones and nipple erections. You might never look at your nipples the same way again! Distinguished Professor Barry Komisurak and Lactation Specialist Alia Macrina Heise join us. Find our transcript here: https://bit.ly/ScienceVsSadNippleSyndrome In this episode, we cover: (00:00) Meet Sad Nipple Syndrome (05:14) Why is Nipple Play Arousing? (09:58) Dysphoric Milk Ejection Reflex (D-MER) (15:14) How Milk Ejects From a Booby (17:33) Is Oxytocin to blame?  (19:36) Suspect Number 2: Dopamine (20:52) What might help This episode was produced by Wendy Zukerman, with help from Meryl Horn, Rose Rimler, Michelle Dang and Ekedi Fausther-Keeys. We’re edited by Blythe Terrell. Fact checking by Erica Akiko Howard. Mix and sound design by Bobby Lord. Music written by Emma Munger, So Wiley, Peter Leonard, Bumi Hidaka and Bobby Lord. A special thanks to the researchers we reached out to including Dr. Christina Raimondi, Professor Caroline Pukall, Professor Craig Richard, and Prof. Dr. Inga D. Neumann. and a big thanks to Joseph Lavelle Wilson and the Zukerman family. Science Vs is a Spotify Studios Original. Listen for free on Spotify or wherever you get your podcasts. Follow us and tap the bell for episode notifications.  Learn more about your ad choices. Visit podcastchoices.com/adchoices
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