Masters of Scale

Renee Wegrzyn spent her career building the future of American science — including ARPA-H, the White House agency created to accelerate health breakthroughs. Then the Trump administration showed her the door. Wegrzyn co-founded Transfyr to tackle what she calls one of the most overlooked issues in science: the magic hands problem. She joins Rapid Response to explain why fixing this unglamorous bottleneck is the prerequisite f...

Thibault “Tibo” Sottiaux is OpenAI’s head of Product & Platform, making him responsible for the AI tools used by more than a billion users worldwide. Rana el Kaliouby spoke with Tibo on Pioneers of AI about why he’s “proud” OpenAI delayed its latest Astra model over safety concerns, the new suite of agentic products released at DevDay, and what it’s like to lead inside a frontier AI com...

Alyssa Ravasio loves using ‘coyote trickster energy’ to get more people to put down their technology. Her camping marketplace, Hipcamp, has grown into the largest source for booking campsites on public and private land. She talks with host Jeff Berman about scaling the company, learning to prioritize your health as a founder, and more. 

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Prediction markets incentivize truth. Everything else incentivizes clickbait. That's the core argument Luana Lopes Lara makes for Kalshi — the prediction market platform she co-founded that has gone from $5 billion to $22 billion in valuation in under a year, and is now being sued by New York's attorney general for $36 billion. Luana joins Rapid Response to make the case that Kalshi is fundamentally different from DraftKings ...

Jennifer Ferro is the former board chair of NPR and president of Southern California’s iconic public radio organization: KCRW. Ferro talks with host Jeff Berman about how nearly two decades as the founder’s deputy taught her to lead, why she thinks we deserve a better internet, and how the best defense of getting ignored is simple: Don’t be boring.

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The second a brand like Hershey stops being culturally relevant, says its CEO Kirk Tanner, you should be worried. He joins Rapid Response to explain exactly what he's doing to make sure that never happens. Tanner also reveals why GLP-1 users are actually good for the candy business, how AI is now routing Hershey's sales force in real time through Target and Walmart, and why the Reese's Oreo collaboration (which generated $100 milli...

Own or be owned. That's Codie Sanchez's ultimatum for anyone serious about their financial future. The founder of Contrarian Thinking and author of the new book Own or Be Owned returns to Rapid Response to make her most impassioned case yet for why buying a small business is the most reliable path to wealth that most people are too scared to take. She breaks down what "cowboying" your business is costing you, and why AI isn’t...

When Jess Smith became employee number one for the Bay Area’s WNBA expansion team, the future was a blank slate. Now, the Golden State Valkyries brand is boasting a unicorn valuation in just its second season. Smith talks with host Jeff Berman about building the brand from scratch, the rise of women’s professional sports, and why so many women in the C-Suite are former athletes. 

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The world has never faced so many humanitarian crises at once, and the systems built to respond to them are fraying. Tjada McKenna, CEO of Prosper Global — the organization long known as Mercy Corps — joins Rapid Response during UN General Assembly week to share what she's seeing firsthand from Syria to Sudan to Ukraine to Gaza, and why she rebranded a 40-year-old institution in the middle of a funding crisis rather tha...

Author and researcher Brené Brown joined host Reid Hoffman on stage last year in San Francisco for the 2025 Masters of Scale Summit. She reveals insights about how to lead courageously, the underrated skills leaders need to thrive, and why compassion is essential for success – even if it’s currently being crowded out of the zeitgeist. 

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AI isn't simplifying your life… Yet. It's mass-producing more options, more decisions, and more noise. Axios CEO Jim VandeHei returns to Rapid Response to make the case that the antidote isn't a better productivity app, it's a ruthless, three-part system he calls Confront, Delete, Amplify. VandeHei shares what he's learned from running Axios by these principles, including calling a leadership meeting with the subject heading...

On built a $4 billion sports brand in 16 years with a garden hose, a Roger Federer dinner in Zurich, and a young designer who watched a Halloween YouTube video. Co-founder and co-CEO David Allemann joins Rapid Response to explain why the defining decade for On is still ahead, and why being the most premium brand matters more than being the biggest. He breaks down the leadership shake-up that brought him back into a CEO role, and wh...

Autodesk is the massive public software company at the heart of designing almost everything around you, from cars to buildings to video games. CEO Andrew Anagnost talks with host Jeff Berman about why he first joined a “rebel” group at the company, how he battled for the top job, and why he thinks leading with empathy is smart business.

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The NFL is the world's most valuable sports business, and it keeps growing. But is the growth sustainable? Sports journalist Michele Steele joins Rapid Response to kick off the 2026-2027 NFL season with a clear-eyed look at what's driving record franchise valuations, why quarterback salaries keep exploding, and what the league's dizzying array of streaming platforms means for the fans. She also breaks down the NFL's deliberate "Hel...

With the highly anticipated follow up to her bestseller “Grit”, psychologist and author Angela Duckworth offers a new framework for achieving excellence. She talks with host Jeff Berman about why making even small changes to your situation is the precursor to success. 

You can find more about Angela's book Situated here: https://www.simonandschuster.com/books/Situated/Angela-Duckworth/9781668005941

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For decades, e-commerce rewarded the biggest brands who could buy their way to the top of search results. AI is changing that. Shopify COO Jess Hertz joins Rapid Response to share what Shopify's data reveals about the agentic shopping revolution in real time, and how the company is building the infrastructure layer that makes products discoverable and purchasable by AI. Plus, why Shopify's engineers can spend freely on AI tokens wh...

AI is rapidly changing what it means to be human, but is AI development truly human-centered? According to Aza Raskin, co-founder of the Center for Humane Technology, the answer is largely “no.” The man who invented the “infinite scroll” is now working to understand why the most powerful technology so often fails to prioritize the human experience and our collective well-being. Raskin is also leading the Ear...

The economy is strong, prices are still too high, and the job market is sending mixed signals. The Federal Reserve is navigating all of it while fending off the most overt political pressure in its modern history. Austan Goolsbee, President of the Chicago Fed, joins Rapid Response ahead of the Central Bank’s highly-watched meeting in Jackson Hole, to give his most candid read on what's actually going on. He explains why tarif...

With the ongoing disruption in the Strait of Hormuz and fuel prices still elevated, few auto executives are feeling the pressure more acutely than Ford Motor Company CEO Jim Farley. He joins Rapid Response to give a candid account of what the turmoil means for the auto industry, and for an iconic American brand navigating one of the most turbulent moments in its history. Farley gets frank about the China threat reshaping the global...