Big Brains

For decades, traditional cancer treatments like chemotherapy and radiation have targeted tumors directly—often with severe side effects and mixed results. But what if the key to treating cancer was already inside our bodies?

Prof. Thomas Gajewski, a renowned oncologist at the University of Chicago, is leading a revolution by using the body’s gut microbiome to fight cancer. His pioneering work in cancer immunotherapy foc...

What makes a good life? For decades, psychologists have debated whether true fulfillment comes from happiness—a life of comfort and joy—or meaning—a life of purpose and impact. But what if there's a third way?

University of Chicago psychology professor Shigehiro Oishi has spent his career studying happiness, meaning, and what truly brings people deep satisfaction. His new research suggests that some of the most fu...

What if the secret to restoring your focus, improving your mental health, and even reducing crime rates wasn’t found in an app or a pill, but in a tree? In this episode, we speak with University of Chicago psychologist Marc Berman, whose research on “soft fascination” and nature’s cognitive effects is reshaping how we think about everything from urban planning to depression treatment. From groundbreaking hos...

As AI rapidly changes how we work, learn, and communicate, it also raises an urgent question: What does it mean to grow up in a world dominated by smart technology? From smart-baby monitors to stuffed animals embedded with LLMs, kids and parents are increasingly bombarded with AI everywhere they turn.

According to Prof. Dana Suskind, a renowned surgeon and pediatrician at the University of Chicago, AI might be able to mimic languag...

Why does it seem so difficult to cancel an online subscription, delete an account, or opt out of data tracking? You might think it’s just bad luck or a confusing online interface, but more often than not, it’s by design.

In this episode of Big Brains, we speak with Marshini Chetty, Professor in the University of Chicago’s Department of Computer Science. As a leading expert in human-computer interaction, Chetty rev...

Quantum technology is at a pivotal moment. No longer the faraway dream of scientists, the field is rapidly developing across the world, fueled by major investments from governments, industry, and universities racing to lead its promising future. But what exactly is quantum technology? And how will it affect our lives today—and in the coming decades?

A recent event at the University of Chicago, hosted by Big Brains in partners...

From setting interest rates to keeping inflation in check, the Federal Reserve sits at the center of some of the most important economic decisions shaping our daily lives. As the Fed prepares for new leadership, following the tenure of Jerome Powell, many are wondering: What’s next for the Fed, especially when it comes to their financial decisions and their independence?

We spoke with Prof. Douglas Diamond, the Nobel Prize-wi...

What if the way you relate to others isn’t fixed—but fundamentally changeable? In this episode, we speak with psychiatrist and neuroscientist Amir Levine, who is an Associate Professor of Clinical Psychiatry at Columbia University Medical Center.

He's the author of the best-selling book Attached, which examined how people’s attachment styles—from secure to anxious to avoidant. In his new book, Secure: The Re...

What if we could predict the world’s most dangerous weather events—not days, but weeks in advance? Extreme events like heat waves, hurricanes, and floods cause massive loss of life and billions in damage, but they’re also some of the hardest events for traditional weather forecasting to predict.

In this episode, Assoc. Prof. Pedram Hassanzadeh of the University of Chicago explains why forecasting extreme weather h...

In recent years, a judge in one state had gained the power to halt policies across the entire United States. Known as nationwide or universal injunctions, these actions have become one of the sweeping tools in the federal court—affecting cases ranging from student loan forgiveness to environmental policies to birthright citizenship.

How did universal injunctions become such a central feature of modern constitutional battles? ...

Artificial intelligence may live in “the cloud,” but its footprint is firmly on the ground. As AI systems grow more powerful, the data centers that train and run them are consuming massive amounts of land, water and electricity—as well as reshaping regional power grids. What does this surge in demand mean for the environment, energy infrastructure, and the future of innovation?

In this episode, we speak with UChic...

When a two-year-old boy suffered a catastrophic injury that severed the connection between his skull and spine, doctors across Europe told his family there was no hope. His spinal cord was completely severed, and the injury was not considered survivable. But University of Chicago neurosurgeon Mohamad Bydon saw a possibility.

In this episode of Big Brains, Dr. Bydon walks us through the extraordinary, multi-stage surgery at UChicago ...

In today’s world, our brains are overloaded with information, making it hard to focus and remember. But what are the true limits of the human mind—and why do they exist? And why are some people seem so much better than remembering things than others? In this episode, we talk with with Edward Awh, a cognitive neuroscientist and professor of psychology at the University of Chicago. Whose lab studies how the brain controls...

The process of understanding who we are is a lifelong journey for many of us. For two decades, that question has been one that University of Chicago scholar Eric Oliver has asked his students in class—and inspired him to write a new book called "How to Know Your Self: The Art & Science of Discovering Who You Really Are."

A renowned political scientist, Oliver draws upon science, philosophy, psychology and his personal expe...

What if we could precisely measure a cell at its most fundamental level? In this episode, we talk with the University of Chicago scientist Peter Maurer about how he and his colleagues made the breakthrough discovery of turning a protein found in living cells into the first biological quantum bit, also known as a qubit.

Maurer explains how quantum systems—once thought to be too fragile for real-world use—are becoming some...

We've all heard the phrase "Manifest Your Destiny" when it comes to wanting a new promotion, figuring out a new career path or just trying to achieve that long-term goal. It turns out that the act of manifestation is not merely pseudoscience—it actually has a body of research in neuroscience to back it up.

James Doty was a clinical professor of neurosurgery at Stanford University, and founder and director of the Center for Com...

The internet and social media have transformed the way in which we hear and understand music today—and online communities and platforms from YouTube to TikTok have changed how music circulates and ultimately goes viral. Why do some pop stars have more success creating hit songs and building online following than others?

In this episode, we speak with Paula Clare Harper, a musicologist and assistant professor at the University ...