Oxford Sparks Big Questions

Oxford Sparks Big Questions

'Will my bacon sandwich kill me?', 'Is vaping better than smoking?', 'How do you become an astronaut?' - just some of the Big Questions we ask some of the brightest minds behind Oxford science. Join us in each podcast as we explore a different area of science.

Episodes

June 17, 2026 12 mins

Put simply, most drugs work by binding to a protein and altering how they function. But...

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In 2022, 7% of the UK's total carbon emissions came from the aviation sector - a figure that's on the rise. This means that - while a flight is often the start of a well-deserved holiday - a lot of us feel at least a sprinkling of guilt over our carbon footprint. So, what if we could reduce the carbon emissions associated with air travel? In this episode, we chat to Dr Tamsin Whitfield from Oxford's Department of Materials Science,...

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Until recently, most of us had probably never even heard of the hantavirus. Now - with memories of the global COVID-19 pandemic still fresh in our minds - it's only natural to feel slightly concerned about the new virus hitting our headlines. But are our worries justified? We chat to Dr Daniel Wright from the Oxford Vaccine Group, who develops vaccines against emerging outbreak viruses, to learn more about hantaviruses, and what th...

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'Killing animals' and 'conservation' sound mutually exclusive, but when it comes to managing populations that are having a negative environmental impact, is culling the answer? If so, how do people feel ...

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April 22, 2026 12 mins

"It's as likely as winning the lottery." A phrase used in situations where something is, well, pretty near impossible. But is there anything you can do to increase your chances of claiming that life-chan...

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April 8, 2026 13 mins

Aside from the odd unfamiliar or complicated word, a lot of us won't think twice when it comes to reading. It's a skill we take for granted. But, relatively speaking, it's actually a fairly new skill - beginning about 5500 years ago. This suggests it's not something we evolved to do, so, how does it work? We chat to Prof Ole Jensen from Oxford's Departments of Experimental Psychology and Psychiatry, who is trying to gain a better u...

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March 25, 2026 16 mins

Historically, only two women have ever started a Grand Prix race, and as of the 2026 season, no women are competing in Formula One. This male dominancy is by no means restricted to the track, with social scientist Dr Kate Bancroft estimating that a mere 5% of technical motorsport roles (that is, the engineers and mechanics) are taken by women. We hear from Kate about her research into the F1 gender gap, which she hopes - alongside ...

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March 11, 2026 13 mins

We're living in an age of rapid technological development which - alongside many benefits - comes at an environmental cost. We speak to Dr Shurui Miao, an experimental chemist who aims to decouple technological advancement from the impacts of increased carbon emissions, by finding a way to safely store carbon underground. As he explains, by finding a way to convert CO2 from the atmosphere into minerals, we could store carbon secure...

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This week we are featuring a special bonus episode from our friends at the Milk on the Move podcast. Milk on the Move explores milk's deep cultural roots, evolving scientific narratives and the systems that shape its production today. Hosts Johanna Zetterstrom-Sharp and JC Niala uncover the fascinating interaction of tradition, knowledge and morality that makes milk so much more than just an everyday drink. Available on Apple Podca...

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February 25, 2026 11 mins

If you've had the chance to visit Oxford's History of Science Museum, you may have found yourself gazing upon a rather special blackboard. Featuring equations that connect the age, size and density of the Universe, the penmanship is that of Albert Einstein himself, who used the blackboard during a lecture on 16th May 1931. But what was Einstein doing in Oxford, and how did he spend his time there? We chat to Dr JC Niala, Head of Re...

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February 11, 2026 15 mins

For this year's Valentine's Day episode, we are getting up close and personal with those most beloved of birds - penguins. Giving us an insight into the love lives of our feathered friends are penguinologists (yes, that's a real word) Dr Ignacio Juarez Martinez and Dr Fiona Suttle, who have both graduated from Oxford's Department of Biology, and spent multiple field seasons in Antarctica monitoring penguin breeding behaviour. We he...

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January 28, 2026 13 mins

How much more money could you earn - doing the exact same role - if you're in possession of some solid AI skills? That's one of the core questions that Dr Fabian Stephany, a researcher at the Oxford Internet Institute, hopes to answer. Leading the 'SkillScale' project, Fabian looks into the impact of AI tools on the labour market, with the ultimate hope of advising workers on the best ways to secure jobs and increase their salaries...

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January 14, 2026 12 mins

Are we alone in the Universe? It's surely one of the biggest questions out there. In our first episode of 2026 we chat to Dr Carly Howett, Associate Professor of Space Instrumentation in Oxford's Department of Physics. Specialising in the study of the 'icy worlds' found in our outer Solar System, Carly explains why she thinks one of Saturn's moons, Enceladus, could be a prime candidate for life, and shares the latest updates on how...

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We all know it. We've all sung it. Perhaps we've even answered a quiz question about it*. The Twelve Days of Christmas has become as quintessentially festive as a figgy pudding, or the bad joke in your Christmas cracker. But why exactly is your 'true love' gifting all these birds? And importantly, how are they faring n...

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November 26, 2025 15 mins

Want to make something feel immediately complicated, inaccessible or downright mysterious? Stick the word 'quantum' in front of it. Or, at least, that's how many of us feel. But don't worry! Experimental physicist William Cutler from Oxford's Department of Physics is here to break things down, explaining exactly what a quantum computer is, and sharing the remarkable potential that quantum computing holds for advancing fields r...

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Finding a cure for cancer is unarguably one of the biggest medical challenges that we face. But what if we could find a way to prevent cancer before it even starts? In this special extended edition of the Big Questions Podcast, we chat to Professor Sarah Blagden, an experimental oncologist at the University of Oxford, and Anna Fry, who has the cancer predisposing condition Lynch Syndrome - p...

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October 29, 2025 14 mins

Many of us will be familiar with Body-Focused Repetitive Behaviours (BFRBs), perhaps without even realising it. Such behaviours - which include hair-pulling, nail biting and skin picking - can not only cause physical harm, but also often bring feelings of shame. Because of this, open discussion around BFRBs has been limited. In this episode of The Big Questions Podcast, we chat to Prof Clare Mackay from Oxford's Department of Psych...

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August 6, 2025 12 mins

How do you detect a particle that emits no light - in other words, something invisible? This is the intriguing challenge faced by scientists hunting for 'dark matter'. In our series finale, we talk to Elizabeth Bloomfield from Oxford's Department of Physics about dark matter, how we know it exists, and why her research is taking her deep beneath a mountain in Italy in the quest to find it.

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What's the best gift you can give? To the millions of people whose lives have been saved by complete strangers, the answer would be simple: blood. But what exactly happens when blood has been donated, and how do we know it is safe? We chat to Dr Richard Mayne from Oxford's Experimental Medicine Division about genomics, Next-Generation Sequencing, blood screening (...and Star Trek). 

Could you be a blood-donating hero? Blood st...

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June 11, 2025 13 mins

Whether you've been served an advert for it, or just heard about it in the media, it's likely that 'Ozempic' isn't a totally unfamiliar word. Now often associated with weight-loss, Ozempic is actually the brand name for a drug used to treat diabetes. So what exactly is it, how does it work, and is it safe? We chat to diabetes and endocrinology (hormone) expert Dr Annie de Bray to find out.

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