The a16z Show
The a16z Show discusses tech and culture trends, news, and the future – especially as ‘software eats the world’. It features industry experts, business leaders, and other interesting thinkers and voices from around the world. This show is produced by Andreessen Horowitz (aka “a16z”), a Silicon Valley-based venture capital firm. Multiple episodes are released every week; visit a16z.com for more details and to sign up for our newsletters and other content as well!
Episodes
What should school look like if AI can help students learn dramatically faster? Alpha School founder Joe Liemandt argues the answer isn’t to fill the extra time with more academics, but to redesign school around the skills traditional classrooms struggle to teach: agency, teamwork, entrepreneurship, communication, and doing hard things.
Joe joins Erik Torenberg and Horowitz and Andreessen Academy co-founder Gagan Biyani to dis...
AI agents are approaching a point where they can use computers faster than expert humans, turning the user interface itself into a universal way for AI to interact with software. OpenAI’s Ari Weinstein and James Sun argue that computer use is now entering its scaling moment, as better models, faster execution, and stronger safety controls make agents practical for more consumer and enterprise work.
Ari and James join a16z&rsqu...
Can a 10-person startup outperform a company with hundreds of employees? Box CEO Aaron Levie argues AI agents are giving small teams a level of leverage that simply wasn't economically possible before, creating a window for startups to outrun incumbents.
In this episode of Speedrun Office Hours, Aaron explains why founders are shifting from doing the work themselves to orchestrating agents, and why that puts a new premium on strateg...
What does it take to build a company when AI is changing the rules this quickly? Ben Horowitz argues that technology may make companies easier to start, but the hardest parts of entrepreneurship, making decisions under uncertainty, building momentum, and managing your own doubts, aren't going away.
Speedrun's Andrew Chen sits down with Ben to discuss why AI feels different from previous technology shifts, whether billion-dollar comp...
Amazon expects to spend roughly $220 billion in CapEx in 2026, yet CEO Andy Jassy says the company is still leaving meaningful AI demand on the table.** He believes the buildout could ultimately help make AWS a $1 trillion annual run-rate business.
Andy joins a16z co-founder Ben Horowitz and Erik Torenberg to discuss why AI demand is growing so quickly, how Amazon decides how much infrastructure to build, and why lower inference cos...
a16z is expanding a16z crypto into a16z Frontier, a broader mandate to back founders building at the edges of what's possible. Chris Dixon joins Marc Andreessen, Ben Horowitz, and Erik Torenberg to explain why founders should increasingly ask not “is this too ambitious?” but “is this ambitious enough?” — and how AI could pull decades of technological progress forward across hardware, robotics, entertai...
AI agents can reason over enormous amounts of information, but much of the world’s actual work is still trapped in PDFs, spreadsheets, scans, and other formats that models struggle to reliably understand. Reducto co-founder and CEO Adit Abraham argues that solving this document layer is essential if agents are going to take on consequential work in healthcare, legal, finance, and insurance.
Adit joins a16z General Partner Jenn...
More than 300 million people use ChatGPT for health and wellness questions each week. OpenAI’s Karan Singhal thinks that’s only the beginning: the longer-term goal is AI that can help people navigate their health proactively, while making trustworthy medical intelligence dramatically more accessible.
Karan joins a16z Partner Jay Rughani to explain why OpenAI trains healthcare expertise directly into its general-purpose f...
Why hasn't AI transformed everyday work as quickly as coding? Town CEO Jean-Denis Greze argues the bottleneck isn't intelligence, but making AI useful to people who don't have the time or technical skills to build their own automations.
Jean-Denis joins a16z General Partner Alex Rampell to share why he pivoted Town from tax software to a personal AI assistant built around email, calendars, and the workflows that run businesses. They...
What changes when an AI mistake doesn’t just hurt a benchmark score, but affects someone’s housing or healthcare? EliseAI Head of Applied Research Mario Martone argues that deploying AI in essential industries requires a very different standard of reliability.
Mario joins MTS to explain how EliseAI handles roughly 5 million phone calls a month, why LLMs aren’t the right solution for every problem, and how the team ...
Why is booking a doctor's appointment still so difficult, and can AI finally change that? Zocdoc CEO Oliver Kharraz argues that the real problem isn't finding doctors, but connecting patients to accurate availability and making appointments bookable wherever they start their search.
Oliver joins a16z General Partner Julie Yoo to discuss how Zocdoc spent nearly 20 years building the infrastructure behind online scheduling, and why it...
a16z General Partner Martin Casado sits down with Grepr CEO Jad Naous to ask what comes after AI learns to write code: can it also debug and operate the systems that code creates?
Jad shares how AI has transformed engineering inside his 10-person team, cutting some projects from six months to just 10 days. But operating production systems is a harder challenge, with unpredictable workloads, failures, and countless possible states.
Th...
a16z General Partner Alex Rampell sits down with VGS Executive Board Member, Terry Angelos, to unpack what happens to payments when AI agents go from recommending what to buy to actually making the purchase.
Terry explains the infrastructure required to safely give agents access to payment credentials, why wallets like PayPal, Shop Pay, and Link are competing to become the default payment layer for agents, and how new agentic tokens...
a16z Partner Lisha Li sits down with AI researcher and Trillium founder Nathan Lambert to ask how durable the gap really is between frontier AI labs and open models.
Nathan argues that OpenAI and Anthropic have structural advantages in compute, capital, and the ability to pioneer new training paradigms, but open-model labs, particularly in China, have proven remarkably capable of following close behind. They unpack how much of that ...
Could AI break the cryptography protecting everything from crypto wallets and banking to private messages? Recent advances in AI-driven mathematical research have sparked new warnings about the security of today's encryption systems, but how much of the concern is supported by evidence?
a16z crypto's Liz Harkavy is joined by Stanford cryptographer Dan Boneh, a16z crypto General Partner Eddy Lazzarin, and Research Partner Justin Thal...
a16z General Partner Martin Casado sits down with MakerMaker.AI co-founders Dhaval Adjodah and Owen He to unpack recursive self-improvement, or RSI, and separate the increasingly popular term from what it would actually mean for an AI system to improve itself.
Dhaval and Owen distinguish true RSI from simply using AI to automate pieces of AI development. Their goal is a closed loop where the system being improved is also doing the i...
Nick Bostrom joins Theo Jaffee and Sofia Puccini on MTS to revisit the ideas about superintelligence and existential risk that he helped bring into the mainstream, now that increasingly capable AI systems actually exist.
Nick discusses why reinforcement learning may be pushing models toward more goal-seeking behavior, what recent agent experiments tell us about instrumental convergence, and why he favors preserving the ability to sl...
a16z co-founder and General Partner Ben Horowitz joins James Norman on the inaugural episode of Vintage x Vintage for a conversation spanning entrepreneurship, investing, hip-hop, and what changes when AI makes building dramatically easier.
Ben reflects on going from Netscape to becoming a first-time CEO, why every founder eventually hits a “we’re fucked, it’s over” moment, and what he learned from building a...
a16z's Raghu Raghuram and Guido Appenzeller sit down with Playground Global General Partner and former Intel CEO Pat Gelsinger to discuss the next wave of semiconductor innovation and the physical constraints shaping the AI buildout.
Drawing on his experience designing Intel's 386 and 486 processors, Pat explains how AI could transform chip design, but also why faster design alone won't solve the industry's biggest problems. They ex...
a16z’s Raghu Raghuram sits down with AWS CEO Matt Garman to discuss how AI is reshaping the cloud, from the needs of AI-native startups to infrastructure increasingly designed for agents.
Matt explains how AWS is adapting as agents write code and manage infrastructure, why it’s reserving scarce GPU capacity for startups, and where custom chips like Trainium and Graviton fit into the AI stack.
They also discuss Amazon's $2...
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