In this episode, Jayson M. Antonio and Ronaldo P. Ferraris discuss their team’s recently published study, "Lacticaseibacillus rhamnosus GG-driven remodeling of arginine metabolism mitigates gut barrier dysfunction." The research reveals a novel probiotic-driven mechanism that links dietary tryptophan with host arginine metabolism. The probiotic Lacticaseibacillus rhamnosus GG, when combined with tryptophan, enhances gut barrier integrity by upregulating argininosuccinate lyase (ASL), a key enzyme in arginine biosynthesis. The study also identifies ASL downregulation and increased serum argininosuccinate levels in a mouse model of colitis, pointing to a promising target for precision probiotic therapies.
Lacticaseibacillus rhamnosus GG-driven remodeling of arginine metabolism mitigates gut barrier dysfunction Jayson M. Antonio, Yue Liu, Panan Suntornsaratoon, Abigail Jones, Jayanth Ambat, Ajitha Bala, Joshua Joby Kanattu, Juan Flores, Sheila Bandyopadhyay, Ravij Upadhyay, Jagannatham Naidu Bhupana, Xiaoyang Su, Wei Vivian Li, Nan Gao, and Ronaldo P. Ferraris
American Journal of Physiology-Gastrointestinal and Liver Physiology 2025 329:1, G162-G185
Popular Podcasts
Stuff You Should Know
If you've ever wanted to know about champagne, satanism, the Stonewall Uprising, chaos theory, LSD, El Nino, true crime and Rosa Parks, then look no further. Josh and Chuck have you covered.
Crime Junkie
Does hearing about a true crime case always leave you scouring the internet for the truth behind the story? Dive into your next mystery with Crime Junkie. Every Monday, join your host Ashley Flowers as she unravels all the details of infamous and underreported true crime cases with her best friend Brit Prawat. From cold cases to missing persons and heroes in our community who seek justice, Crime Junkie is your destination for theories and stories you won’t hear anywhere else. Whether you're a seasoned true crime enthusiast or new to the genre, you'll find yourself on the edge of your seat awaiting a new episode every Monday. If you can never get enough true crime... Congratulations, you’ve found your people. Follow to join a community of Crime Junkies!
The Breakfast Club
The World's Most Dangerous Morning Show, The Breakfast Club, With DJ Envy, Jess Hilarious, And Charlamagne Tha God!