In this episode, coauthors Cecilia Delprete, Friederike Uhlig, Marco Caprini, and Niall P. Hyland dive into their latest research titled "Characterization of Fabry disease-associated lyso-Gb3 on mouse colonic ion transport and motility."
Fabry disease (FD) is a rare genetic disorder with wide-ranging effects across the body, including the gastrointestinal (GI) system—often one of the first to show symptoms. The team explores how the lipid molecule lyso-Gb3, known to accumulate in FD, affects colonic function using ex vivo techniques like Ussing chambers and organ baths.
The conversation covers key findings: lyso-Gb3 significantly alters ion transport in the colon but doesn't affect motility or nerve responses, suggesting a complex mechanism behind GI symptoms in FD patients. Could this bring us closer to understanding—and eventually treating—the GI discomfort that burdens so many with Fabry disease? Tune in today!
Characterization of Fabry disease-associated lyso-Gb3 on mouse colonic ion transport and motility Cecilia Delprete, Friederike Uhlig, Marco Caprini, and Niall P. Hyland
American Journal of Physiology-Gastrointestinal and Liver Physiology 2024 327:6, G810-G817
Popular Podcasts
Crime Junkie
Does hearing about a true crime case always leave you scouring the internet for the truth behind the story? Dive into your next mystery with Crime Junkie. Every Monday, join your host Ashley Flowers as she unravels all the details of infamous and underreported true crime cases with her best friend Brit Prawat. From cold cases to missing persons and heroes in our community who seek justice, Crime Junkie is your destination for theories and stories you won’t hear anywhere else. Whether you're a seasoned true crime enthusiast or new to the genre, you'll find yourself on the edge of your seat awaiting a new episode every Monday. If you can never get enough true crime... Congratulations, you’ve found your people. Follow to join a community of Crime Junkies! Crime Junkie is presented by audiochuck Media Company.
24/7 News: The Latest
The latest news in 4 minutes updated every hour, every day.
Stuff You Should Know
If you've ever wanted to know about champagne, satanism, the Stonewall Uprising, chaos theory, LSD, El Nino, true crime and Rosa Parks, then look no further. Josh and Chuck have you covered.