In this episode of Cardio Buzz, we explore the intriguing concept of the 'legacy effect' of medications like those used in treating diabetes, hypertension, hypercholesterolemia, and chronic kidney disease. We'll delve into landmark studies like the UKPDS, Steno-2, and more, examining the lasting impacts of medications such as Repatha, Candesartan, and Empagliflozin. Learn how these drugs contribute to disease regression, modify genes, and prevent non-fatal events to grant long-term protective effects.
00:00 Introduction: The Challenge of Lifelong Medication 00:57 Exploring the Legacy Effect of Medications
01:33 Diabetes Medications: Long-Term Benefits
03:15 Hypertension Medications: Persistent Effects
03:58 Cholesterol Medications: Lasting Impact
04:49 Kidney Disease Medications: Prolonged Benefits
06:12 Understanding the Legacy Effect Mechanism
09:13 Implications and Final Thoughts
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