Dr. Brendan McCarthy

Many women are prescribed oral estrogen without ever being told what happens after it enters the body. In this episode, Dr. Brendan McCarthy takes a deeper look at estrone, the estrogen metabolite created when estradiol is taken orally, and explains why the delivery method of hormone therapy matters.

You'll learn:

• The difference between estradiol and estrone
• Why oral estrogen creates ...

In this episode, Dr. Brendan McCarthy breaks down one of the most misunderstood topics in hormone replacement therapy: estradiol.

Not all estrogen is the same—and how estradiol is delivered can dramatically affect hormone balance, inflammation, clotting risk, testosterone levels, and overall health outcomes.

Dr. McCarthy discusses:

• Why route of administration matters (oral, patch, injectable, topical, vaginal, pellet) • How...

After 16 episodes exploring food, metabolism, cravings, and health, Dr. Brendan McCarthy shares the most important lesson of all:

Your body is not broken.

Too often, health conversations focus on calories, diets, lab results, and willpower. But lasting change isn't just about what you eat—it's about understanding why you eat, what your body is responding to, and replacing shame with compassion.

In this powerful conclusion to ...

This episode is about more than food.

It's about understanding why we reach for certain foods, creating a realistic off-ramp from ultra-processed eating, and giving your body a chance to reset.

If you've ever felt like you're doing everything right but still struggling with weight, energy, inflammation, or cravings, this episode is for you.

Citation:

Hall, Kevin D., et al. “Ultra-Processed Diets Cause Excess Calor...

Most diets fail because they never address what the food was doing for you emotionally.

In this episode, Dr. Brendan McCarthy explains the stress-craving loop behind emotional eating, why ultra-processed foods feel impossible to resist, and how shame actually reinforces the cycle.

You’ll learn: • Why cravings feel automatic • How stress drives food urg...

Why is it so hard to stop eating ultra-processed foods — even when you know they’re hurting you?

In Episode 13 of this 16-part series, Dr. Brendan McCarthy explains why the real problem is not just the food itself. The real problem is the loop:

Cue or emotional state → Wanting → Bargaining → Consumption → Temporary relief → Crash/regret → Repeat.

...

In this episode, Dr. Brendan McCarthy dives deep into the psychology of ultra-processed foods, compulsive eating, shame, and why so many people feel trapped in unhealthy food cycles.

This conversation goes far beyond calories and willpower.

Dr. McCarthy explains how ultra-processed and hyper-palatable foods are intentionally engineered to drive repeat consum...

Why do so many people know what to eat… but still can’t follow through?

In this episode, Dr. Brendan McCarthy breaks down the powerful connection between trauma, stress, and ultra-processed foods—and why willpower alone is not enough.

You’ll learn how the nervous system, PTSD, and chronic stress can rewire your relationship with food, driving cravings and behaviors that feel out of your control.

This isn&rs...

Today, we’re diving into a topic that should be getting far more attention:

Cardiovascular disease in women.

Heart disease is one of the leading causes of death in women—yet it’s often under-addressed, oversimplified, and misunderstood in clinical practice.

Most women are told: “Eat better. Take this prescription.”

But that approach misses something critical.

Full citation list:    •   &...

Today, we’re diving into autoimmunity—what it actually is, why it happens, and how ultra-processed foods may be contributing to the problem.

Autoimmune disease is often misunderstood. Some will tell you diet has nothing to do with it. Others claim diet is the cure. The truth is more nuanced—and that’s exactly what we explore in this episode.

You’ll learn:

• What autoimmunity really is (and why it&rs...

GLP-1 medications like semaglutide and tirzepatide are everywhere right now—but are they actually solving the problem?

In Episode 8 of this 16-part series on ultra-processed foods, Dr. Brendan McCarthy breaks down the truth about GLP-1 medications: how they work, why they can feel like a “miracle,” and where things go wrong when they’re used without proper medical guidance.

This isn’t about shame. It&r...

Craving junk food when you’re stressed isn’t a lack of discipline — it’s biology.

In this episode, Dr. Brendan McCarthy breaks down what ultra-processed and hyper-palatable foods actually do inside your body — from your metabolism to your hormones, your brain, and your stress response.

But this isn’t about guilt or shame.

It’s about understanding what you’re up against — especia...

In this episode, Dr. Brendan McCarthy—Chief Medical Officer at Protea Medical Center—dives into one of the most misunderstood topics in health:

Why does it feel like you can’t stick to a diet… even when you’re trying your best?

This isn’t about willpower. It’s not a character flaw. And it’s not your fault.

Dr. McCarthy breaks down the biology behind stress, cravings, and weight gain&...

Is weight gain really about willpower… or is something deeper going on?

In this episode, Dr. Brendan McCarthy, Chief Medical Officer at Protea Medical Center, breaks down the real biology behind stress, cravings, and weight gain—and why blaming yourself (or cortisol) is missing the point.

You’ll learn:

• Why chronic stress rewires your metabolism

• How stress drives cravings for ultra-processed foods

• The tr...

We’ve all heard it: calories in vs. calories out. And while that’s not wrong… it’s not complete.

Dr. McCarthy breaks down the three major approaches to weight loss:

1. Calorie restriction

2. Insulin management (low-carb, keto, etc.)

3. Exercise & performance

…and explains why each works—but still falls short on its own.

The missing piece? The signal your food sends to your body.

This episod...

Why do you crave dessert after dinner? Why are you hungry again an hour after eating? And why does weight sometimes seem to accelerate even when you're watching calories?

In Episode 3 of this series on ultra-processed and hyper-palatable foods, Dr. Brendan McCarthy breaks down the biology behind cravings, hunger, and weight gain. This episode connects the dots between food engineering, blood sugar spikes, insulin, and the brain&rsq...

In this episode, we’re diving deep into ultra-processed foods — and why cravings in your 30s, 40s, and 50s are not a character flaw.

If you’ve ever:

• Felt compulsive around certain foods

• Wondered why you “used to have more willpower”

• Eaten for stress relief and felt ashamed afterward

• Asked yourself why your partner can stop but you can’t

This episode is for you.

There are three ...

If you're a woman in your late 30s, 40s, or 50s and you feel swollen, inflamed, stuck, exhausted, or like your body has completely turned against you — this series is for you.

Let’s be clear: This is NOT a diet episode. This is NOT food shaming. This is NOT about willpower.

This is upstream endocrinology.

In this episode, Dr. McCarthy explains:

• Why weight gain in perimenopause is not a discipline problem

• How est...

In this final episode of the Progesterone Promise series, Dr. Brendan McCarthy, Chief Medical Officer of Protea Medical Center, breaks down one of the most misunderstood hormones in women’s health: progesterone.

Progesterone is not “good” or “bad.” It’s contextual.

In today’s world of quick sound bites and social media medicine, hormones are often reduced to oversimplified claims like &ldqu...