Inside Matters

Inside Matters

The gut health show – conversations with the most forward-thinking minds in health, fitness, science, nutrition and business. In-depth discussions about how our gut microbiome impacts our health, well-being, mood and more. Inside Matters was conceived by microbiome expert Dr James McIlroy as a platform to raise awareness of the importance of the gut microbiome. Our aim is to inspire and educate listeners around the world about the importance of gut health, equipping them with the knowledge they need to transform their lives for the better.

Episodes

December 4, 2025 59 mins

Dr Debra Silberg joins Inside Matters for a deep, wide-ranging conversation on gut health, drug development, and the future of microbiome therapeutics.

Dr Silberg is the Chief Scientific Officer at Beyond Celiac, a former global clinical leader at Shire/Takeda and AstraZeneca, and one of the most respected figures in GI medicine and microbiome science.

In this episode, we explore: • How she moved from basic science to medicine to p...

Mark as Played

In this episode, Dr James McIlroy chats with Dr Tanya Mongan, clinical associate professor and gastroenterology consultant at the University of Nottingham. Dr Mongan specialises in gut health, particularly the gut–brain connection and faecal microbiota transplantation (FMT).

She talks us through the current state of FMT, why it works so well, and how it’s becoming an increasingly important treatment for conditions like inflammatory...

Mark as Played

Revolutionising Liver Health: The Link Between Gut Health, Genetics, and Lifestyle

In this episode, we dive deep into the intricate connections between liver health, gut health, genetic predispositions, and lifestyle factors. Our guest, Gary, a seasoned physician and entrepreneur, shares his extensive experience from pioneering liver disease research in the 90s to running a successful metabolic clinic focused on functional medicine...

Mark as Played

In this episode, Dr. James McIlroy interviews Dr. Ran Blekhman, an associate professor at the University of Chicago, about the microbiome and its role as 'our second genome.'

Dr. Blekhman shares his research findings on the genetic and environmental factors that shape the microbiome, the heritability of microbial genes, and the relationship between the human genome and microbiome. They also discuss Dr. Blekhman's groundbreaking res...

Mark as Played

In this episode of Inside Matters, I'm joined by Dr Johan van Hylckama Vlieg, Chief Scientific Officer at Freya Biosciences. As a global leader in microbiome research, Freya is pioneering innovative approaches to women’s health through biotherapeutics that are rooted in groundbreaking microbiome science.

00:00 Introduction to Dr. Johan van Hylckama Vlieg and Freya Biosciences 01:39 The Potential of the Microbiome 03:08 Challenges i...

Mark as Played

The Gut-Health Revolution | Dr Chris Damman on Nutrition, Microbiome & the Future of Wellness

Dr Chris Damman brings decades of experience from the biotech world and leading global foundations to share his vision for the future of health and nutrition. In this episode, we dive deep into the transformative power of gut health and the emerging science shaping how we eat and live.

Gut Health: Ancient Wisdom Meets Modern Science Dr...

Mark as Played
In this episode of Inside Matters, Dr James McIlroy is joined by Professor Yan Yiannakou to discuss the developments in IBS treatment.

Irritable bowel syndrome (IBS) is often brushed off as little more than an inconvenience. But in a recent conversation between Dr James McIlroy and Professor Yan Yiannakou, a consultant gastroenterologist with decades of experience, it’s clear that IBS is far more serious than many realise. Their di...

Mark as Played

In this episode of Inside Matters, Dr. James McIlroy sits down with Cory Greenberg, a professional cyclist and founder of Ride4IBD.

Cory shares his inspiring journey from his initial diagnosis of inflammatory bowel disease (IBD) while training as a professional cyclist, to overcoming the challenges posed by the disease. The conversation covers his approach to gut health in the context of athletic performance, insights into training...

Mark as Played

In this episode of Inside Matters, Dr James McIlroy explores the remarkable evolution of Faecal Microbiota Transplantation (FMT), from its unlikely beginnings to its promising future—and shares exciting new data from his company, EnteroBiotix.

We begin with the pioneering efforts of Mr Ben Eisman in 1958, whose early use of FMT saved lives in cases of severe diarrhoea. From there, Dr McIlroy takes us through decades of progress, cu...

Mark as Played

In a fascinating conversation with Professor Max Nieuwdorp of the Amsterdam Medical Centre, Dr James McIlroy explores groundbreaking ideas and research surrounding the microbiome, hormones, and their profound impact on metabolic diseases. This insightful dialogue uncovers the remarkable potential of faecal microbiota transplant (FMT) and emerging pharmaceutical strategies in tackling obesity, diabetes, and even cancer.

Timestamps:

...

Mark as Played

Exploring the Human Microbiome with Dr. Joël Doré: The Future of Gut Health Science

In this episode of Inside Matters, Dr James McIlroy engages in an enlightening conversation with Dr. Joël Doré, Research Director at the French National Research Institute for Agriculture, Food and Environment (NRAE). With over 40 years of experience in microbiome research, Dr. Doré shares his extensive knowledge on probiotics, gut health protocols,...

Mark as Played
January 9, 2025 15 mins
In this episode, James discusses the progress and future of EnteroBiotix, a company focused on gut health and microbiome therapeutics. He reflects on the transformative year of 2024, highlighting significant milestones in clinical trials, particularly in liver disease and irritable bowel syndrome (IBS). James emphasises the importance of clinical data in drug development and the company's commitment to improving patient care throug...
  • Mark as Played

    In a conversation with Dr. James Kinross, a senior lecturer and consultant surgeon at Imperial College London, various aspects of the human microbiome are explored. He is also the author of "Dark Matter: The New Science of the Microbiome".

    Dr. Kinross discusses what constitutes a healthy microbiome and the challenges in analyzing it. The conversation also covers new research linking microbiomes to the effectiveness of cancer drugs,...

    Mark as Played

    In this episode of Inside Matters, Dr. James McIlroy is joined by Professor Anthony Hobson, founder and CEO of the Functional Gut Clinic.

    They discuss gut health diagnostics and treatments, focusing on the evolution of gut health understanding and therapies. Key topics include microbiome diagnostic testing, the importance of understanding gut functions, the impact of lifestyle on gut health, and the effi...

    Mark as Played

    In this conversation, Dr James McIlroy and Emma Storey-Gordon discuss common myths and misconceptions surrounding health, fitness, and nutrition.

    They explore the law of diminishing returns in exercise, the latest science in nutrition including fasting and protein consumption, and the importance of meal timing and insulin sensitivity.

    Emma shares practical advice on setting nutrition targets, the gradual increase of fibre intake fo...

    Mark as Played
    In the latest episode of Biome Bites, Dr James McIlroy returns after a hiatus to share valuable insights into gut health.   Learn about the significant role of polyphenol-rich foods such as dark chocolate, green tea, and berries, and how incorporating them can benefit your gut microbiome. The episode also delves into the importance of meal spacing for digestive health and introduces the diaphragmatic breathing technique, which can ...

    Mark as Played

    In this Biome Bite, Dr James McIlroy 3 myths and misconceptions about the gut microbiome.

    Timecodes:

    00:00:00 Intro

    00:00:56 Weight of the microbiome

    00:04:39 We’re more microbial than human

    00:07:00 Microbiota is inherited from our mothers

     What we're talking about today on this Biome Bite is microbiome myths and misconceptions. We're going to cover 3.

    There's this lovely article written by Professor Alan Walker, who's been on the...

    Mark as Played

    In this episode of Biome Bites, we go back to basics to cover the overall importance of gut health while addressing some common misconceptions and myths.

    00:00:00 Intro

    00:00:44 Importance of gut microbiome

    00:02:22 Misinformation addressed

    00:04:21 Gut health is more than the stomach

    00:08:12 Different bacteria in the gut

    00:10:31 Functions of the ...

    Mark as Played

    The following is a conversation with Dr. Momo Vuyisich, co-founder and chief scientific officer at Viome. Viome is a life sciences company that analyses the activities in your oral microbiome, gut microbiome, and blood using RNA, essentially measuring gene expression.

    This gives the company the ability to be able to assess what the microbiome in these various areas of the body is doing and gives insights into potentially how that l...

    Mark as Played

    The following is a conversation with Professor Jack Gilbert, a professor at the University of California, San Diego, along with his many other very interesting titles and job roles. This includes the co-founder of the Earth Microbiome Project, the American Gut Project, and also featured in the very popular recent Netflix documentary, Hack Your Health.

    He is a master of the microbiome. We covered all aspects of the microbiome, the o...

    Mark as Played

    Popular Podcasts

      If you've ever wanted to know about champagne, satanism, the Stonewall Uprising, chaos theory, LSD, El Nino, true crime and Rosa Parks, then look no further. Josh and Chuck have you covered.

      My Favorite Murder with Karen Kilgariff and Georgia Hardstark

      My Favorite Murder is a true crime comedy podcast hosted by Karen Kilgariff and Georgia Hardstark. Each week, Karen and Georgia share compelling true crimes and hometown stories from friends and listeners. Since MFM launched in January of 2016, Karen and Georgia have shared their lifelong interest in true crime and have covered stories of infamous serial killers like the Night Stalker, mysterious cold cases, captivating cults, incredible survivor stories and important events from history like the Tulsa race massacre of 1921. My Favorite Murder is part of the Exactly Right podcast network that provides a platform for bold, creative voices to bring to life provocative, entertaining and relatable stories for audiences everywhere. The Exactly Right roster of podcasts covers a variety of topics including historic true crime, comedic interviews and news, science, pop culture and more. Podcasts on the network include Buried Bones with Kate Winkler Dawson and Paul Holes, That's Messed Up: An SVU Podcast, This Podcast Will Kill You, Bananas and more.

      Dateline NBC

      Current and classic episodes, featuring compelling true-crime mysteries, powerful documentaries and in-depth investigations. Follow now to get the latest episodes of Dateline NBC completely free, or subscribe to Dateline Premium for ad-free listening and exclusive bonus content: DatelinePremium.com

      The Clay Travis and Buck Sexton Show

      The Clay Travis and Buck Sexton Show. Clay Travis and Buck Sexton tackle the biggest stories in news, politics and current events with intelligence and humor. From the border crisis, to the madness of cancel culture and far-left missteps, Clay and Buck guide listeners through the latest headlines and hot topics with fun and entertaining conversations and opinions.

    Advertise With Us
    Music, radio and podcasts, all free. Listen online or download the iHeart App.

    Connect

    © 2025 iHeartMedia, Inc.