How Your Circadian Clock Affects Your Testosterone- Deep Dive

This Beyond Testosterone podcast episode comes from an academic review article from the Asian Journal of Andrology, published in September-October 2025. This article, titled "Regulation of testosterone synthesis by circadian clock genes and its research progress in male diseases," examines the relationship between circadian rhythms and testosterone production in males. It explores how circadian clock genes centrally and peripherally regulate testosterone synthesis and secretion, and how disruptions in these rhythms are linked to various male health issues, including late-onset hypogonadism, erectile dysfunction, male infertility, and prostate cancer. The authors also discuss potential therapeutic approaches, such as chronotherapy and non-pharmacological interventions, for these conditions based on circadian rhythmicity. The episode concludes by highlighting current limitations in research and suggesting future directions for investigation.