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July 9, 2025 47 mins

All the neurochemicals in the brain have to do with life in the present. Except for one: dopamine. Dopamine is the one neurochemical that looks to the future. It anticipates what may be to come and drives you towards it.

That can be a good thing — dopamine is one powerful motivator — but it also has its downsides. Here to help us understand how the most important chemical in the brain works and how to deal with its pitfalls is Michael Long. Michael is a trained physicist turned writer whose latest book is Taming the Molecule of More. Mike and I discuss how dopamine, for better and worse, makes you want what you don't have. He shares what causes low dopamine activity, how to know if you're experiencing it, and what increases dopamine. We then talk about how to deal with the consequences of dopamine in some of the scenarios in which it plays a role — like losing the spark in a relationship and getting stuck in a smartphone scroll habit — and why so much of taming dopamine comes down to living in the here and now. We end our conversation with why The Great Gatsby is really a novel about dopamine and the fundamental answer to not letting the dopamine chase lead you around.

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