Sean Carroll's Mindscape: Science, Society, Philosophy, Culture, Arts, and Ideas

The germ theory of disease is a crowning achievement of science, up there with modern physics, continental drift, and evolution via natural selection. (Even if there will always be cranky skeptics.) But the road to widespread acceptance isn't always an easy one. Why did it take so long between Anton van Leeuwenhoek seeing "animalcules" in a microscope (1670s) to Louis Pasteur's work on pasteurization and vaccination (...

Questions about consciousness range from the precise and empirical -- what neurons fire when I have some particular experience -- to the deeply profound -- does consciousness emerge from matter, or does matter emerge from consciousness? While it might be straightforward to think that consciousness arises from the collective behavior of atoms in the brain, Annaka Harris and others argue that consciousness could be the funda...

Welcome to the April 2025 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patreons, whittle them down to a more manageable number -- based primarily on whether I have anything interesting to say about them, not whether the questions themselves are good -- and sometimes group them together if th...

Cosmologists were, let us be honest, pretty stunned in 1998 when observations revealed that the universe is accelerating. There was an obvious plausible explanation, the cosmological constant proposed by Einstein, which is equivalent to a constant vacuum energy pervading space. But the cosmological constant was known to be enormously smaller than its "natural" value, and it seems fine-tuned for it to be...

Consciousness is easier to possess than to define. One thing we can do is to look into the brain and see what lights up when conscious awareness is taking place. A complete understanding of this would be known as the "neural correlates of consciousness." Once we have that, we could hopefully make progress on developing a theoretical picture of what consciousness is and why it happens. Today's guest, Christof Koch, is a lea...

We often study cognition in other species, in part to learn about modes of thinking that are different from our own. Today's guest, psychologist/philosopher Alison Gopnik, argues that we needn't look that far: human children aren't simply undeveloped adults, they have a way of thinking that is importantly distinct from that of grownups. Children are explorers with ever-expanding neural connections; adults are exploiters wh...

Welcome to the March 2025 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patreons, whittle them down to a more manageable number -- based primarily on whether I have anything interesting to say about them, not whether the questions themselves are good -- and sometimes group them together if th...

A lot of science goes into crafting the perfect cocktail. Balancing sweet and bitter notes, providing the right amount of aeration and dilution, getting it to just the right temperature and keeping it that way. And even if you have no interest in cocktails as such, the general principles extend to other activities in art and in life. I talk to scientist-turned-mixologist Kevin Peterson about how to think about the simple m...

It is commonplace to refer to the Earth's oceans as vast and largely unexplored. But we do understand some aspects, and improving that understanding is crucial to ensuring the continued viability and success of life on this planet. The oceans are a paradigmatic complex system: there are many components, distinct but mutually interacting, that add up to a nuanced whole. We talk with ocean physicist Helen Czerski about what ...

Political outcomes would be relatively simple to predict and understand if only people were well-informed, entirely rational, and perfectly self-interested. Alas, real human beings are messy, emotional, imperfect creatures, so a successful theory of politics has to account for these features. One phenomenon that has grown in recent years is an alignment of cultural differences with political ones, so that polarization beco...

The Trump administration, led by Elon Musk and his Department of Government Efficiency, has proposed sweeping cuts to spending on science research here in the US, in particular at the National Institutes of Health and the National Science Foundation. I explain a little about what is being cut and why these funds are important to scientific progress. I try, for what it's worth, to provide these explanations in a w...

It is a feature of many human activities - sports, cooking, music, interpersonal relations - that being able to do them well doesn't necessarily mean you can accurately describe how to do them well. Science is no different. Many successful scientists are not very good at explaining what goes into successful scientific practice. To understand that, it's necessary to study science in a scientific fashion. What kinds of scien...

Welcome to the February 2025 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patreons, whittle them down to a more manageable number -- based primarily on whether I have anything interesting to say about them, not whether the questions themselves are good -- and sometimes group them together if...

A typical human lifespan is approximately three billion heartbeats in duration. Lasting that long requires not only intrinsic stability, but an impressive capacity for self-repair. Nevertheless, things do occasionally break down, and cancer is one of the most dramatic examples of such breakdown. Given that the body is generally so good at protecting itself, can we harness our internal security patrol - the immune system - ...

Randomness plays an important role in the evolution of life (as my evil twin will tell you). But random doesn't mean arbitrary. Biological organisms are physical objects, after all, and subject to the same laws of physics as non-biological matter is. Those laws place constraints on how organisms can fulfill their basic functions of metabolism, reproduction, motility, and so on. Easy to say, but how can we turn th...

Big data is ruling, or at least deeply infiltrating, all of modern existence. Unprecedented capacity for collecting and analyzing large amounts of data have given us a new generation of artificial intelligence models, but also everything from medical procedures to recommendation systems that guide our purchases and romantic lives. I talk with computer scientist Tina Elassi-Rad about how we can sift through all this data, m...

A new year, and a new centennial -- 300 (regularly-numbered) episodes of Mindscape! Our tradition is to have a solo episode, and what better topic than the nature of time? Physicists and philosophers have so frequently suggested that time is some kind of illusion that it's become almost passé to believe that it might be fundamental. This is an issue where, despite the form of the question, physics has important things to s...

It's the end of the year, and time for our annual holiday break here at Mindscape. But as usual, we wrap up with a Holiday Message. This year, inspired by Joni Mitchell's "Hits" and "Misses" albums, I go through my scientific papers and talk about some of my favorites -- some of which were hits, in terms of making an impact on subsequent research, and some of which were misses by that standard. But I love them all! It's an...

Living organisms seem exquisitely organized and complex, with features clearly adapted to serving certain functions needed to survive and procreate. Natural selection provides a compelling explanation for why that is so. But is there a bigger picture, a more general framework that explains the origin and evolution of functions and complexity in a world governed by uncaring laws of physics? I talk with planetary scientist a...