In this evidence-packed episode, Dr. Scott Watier and Tommy Welling analyze a brand-new clinical trial comparing 4:3 intermittent fasting versus daily caloric restriction over 12 months. The hosts break down the surprising finding that intermittent fasting participants lost significantly more weight (17 pounds vs 11 pounds) while experiencing a dramatic improvement in their relationship with food, shown by a remarkable two-point reduction in binge eating scores compared to almost no change in the calorie restriction group. They explain why fasting showed better long-term adherence (only 19% dropout rate versus 30% in the calorie counting group) despite both approaches creating the same weekly calorie deficit. The episode highlights how the fasting group was nearly 2.5 times more likely to achieve clinically significant 10% weight loss, and offers practical guidance for adapting this research-backed approach to your own fasting schedule. The hosts also discuss how results might be even better with increased protein intake and resistance training—two factors absent from the original study.
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Article Links:
https://www.acpjournals.org/doi/10.7326/ANNALS-24-01631