December 25, 2025 • 42 mins
In this Huberman Lab Essentials episode, my guest is Dr. Kyle Gillett, MD, a dual board-certified physician in family medicine and obesity medicine and an expert in optimizing hormone levels to improve overall health.
We explain how to improve hormone levels across the lifespan in both men and women using behavioral, nutritional and exercise-based tools. We also discuss common clinical topics, including hormone testing, PCOS, hair loss, testosterone replacement therapy (TRT) and peptides, focusing on potential benefits, tradeoffs and risks.
Read the episode show notes at hubermanlab.com.
Thank you to our sponsors
AG1: https://drinkag1.com/huberman
Maui Nui: https://mauinuivenison.com/huberman
Function: https://functionhealth.com/huberman
Timestamps
(00:00:00) Kyle Gillett
(00:00:36) Hormone Health; Women vs Men, Tool: Hormone Testing
(00:02:35) Tool: Big 6 Lifestyle Pillars to Optimize Hormone Health
(00:04:32) Sponsor: AG1
(00:06:17) Diet, Individualization; Bloodwork & Frequency
(00:07:20) Exercise, Zone 2 Cardio; Caloric Restriction
(00:08:36) Intermittent Fasting, Growth Hormone, IGF-1
(00:11:05) Hormones & Sleep, Growth Hormone, Menopause, Andropause, TRT
(00:13:28) Testosterone & Women, SHGB
(00:15:19) Sponsor: Maui Nui
(00:16:34) Dihydrotestosterone (DHT), Androgens; Turmeric & Black Pepper; Hair Loss
(00:19:47) Polycystic Ovarian Syndrome (PCOS), Symptoms, Metformin, Inositol
(00:23:13) Cannabis, Alcohol, Testosterone
(00:24:48) Males & Testosterone, TRT, Prostate Cancer
(00:26:04) Prolactin, Dopamine "Wave Pool", Tool: Casein & Gluten
(00:27:23) Sponsor: Function
(00:29:03) Social Relationships & Hormones, Tool: Planning for Crisis
(00:31:02) Peptides, Growth Hormone & Risk; BPC 157, Sourcing & LPS
(00:36:42) Melanotan, Uses & Risks
(00:38:45) Spiritual Health, Interdisciplinary Health Integration
(00:41:23) Caffeine & Hormones, Sleep; Acknowledgements
Disclaimer & Disclosures
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