All Episodes

February 9, 2022 69 mins

In Episode 6 of the Lifespan podcast, Dr. David Sinclair and co-host Matthew LaPlante discuss cosmetic aging and how to improve skin, nails, and hair. They talk about why superficial aging occurs and how external signs of aging are often a reflection of biological age. The latest science behind various beautifying therapies is highlighted, including newer interventions like low-level laser therapy and platelet-rich plasma injections.

Thank you to our sponsors:

Our Patreon page: https://www.patreon.com/davidsinclair 

Lifespan book: https://amzn.to/3sUqurT

Dr. David Sinclair Social:

Matthew LaPlante's Social:

To stay up to date with David's work to democratize biological age testing and insights, visit tallyhealth.com.

Timestamps:

(00:00:00) Launching Episode Six: Combating Cosmetic Aging & Improving Skin, Nails & Hair

(00:02:54) Estrogen, Progesterone, and Menopause

(00:09:51) Thanking the Sponsors

(00:12:57) The Pinch Test, Epidermal Thinning, and Foot Ulcers

(00:18:29) Skin and Biological Aging

(00:23:19) Cellular Senescence, Ultraviolet Light, and Skin Aging

(00:28:15) Collagen, Keratin, and Skin Health

(00:33:38) A Quick Aside about Nails

(00:34:45) Autophagy and Retinoids

(00:36:57) Resveratrol, NAD Boosters, and Hyaluronic Acid

(00:41:44) Botox, Skin Peels, and Microneedling

(00:43:28) No Duh Stuff: Sun Damage, Smoking, Alcohol, and Bad Food

(00:45:42) Hair Loss and Hair Graying

(00:49:45) Topical Treatments, Pills, and Dihydrotestosterone

(00:55:19) Frickin Laser Beams: Low-level Laser Therapy

(00:57:59) Platelet-rich Plasma (PRP) Injections

(01:00:11) Hair Aging, Stress, and Gray Hair Reversal

(01:06:11) Targeting Aging Upstream

(01:07:37) Today’s Takeaways

(01:09:25) Subscription and Support Options

For the full show notes, including the peer-reviewed studies, visit the Lifespan podcast website.

Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Lifespan with Dr. David Sinclair podcast, its employees, guests and affiliates assume no liability for the application of the information discussed.

Special thanks to our research assistants, Adiv Johnson & Sarah Ryan.

Mark as Played

Advertise With Us

Popular Podcasts

Las Culturistas with Matt Rogers and Bowen Yang

Las Culturistas with Matt Rogers and Bowen Yang

Ding dong! Join your culture consultants, Matt Rogers and Bowen Yang, on an unforgettable journey into the beating heart of CULTURE. Alongside sizzling special guests, they GET INTO the hottest pop-culture moments of the day and the formative cultural experiences that turned them into Culturistas. Produced by the Big Money Players Network and iHeartRadio.

Crime Junkie

Crime Junkie

Does hearing about a true crime case always leave you scouring the internet for the truth behind the story? Dive into your next mystery with Crime Junkie. Every Monday, join your host Ashley Flowers as she unravels all the details of infamous and underreported true crime cases with her best friend Brit Prawat. From cold cases to missing persons and heroes in our community who seek justice, Crime Junkie is your destination for theories and stories you won’t hear anywhere else. Whether you're a seasoned true crime enthusiast or new to the genre, you'll find yourself on the edge of your seat awaiting a new episode every Monday. If you can never get enough true crime... Congratulations, you’ve found your people. Follow to join a community of Crime Junkies! Crime Junkie is presented by audiochuck Media Company.

The Brothers Ortiz

The Brothers Ortiz

The Brothers Ortiz is the story of two brothers–both successful, but in very different ways. Gabe Ortiz becomes a third-highest ranking officer in all of Texas while his younger brother Larry climbs the ranks in Puro Tango Blast, a notorious Texas Prison gang. Gabe doesn’t know all the details of his brother’s nefarious dealings, and he’s made a point not to ask, to protect their relationship. But when Larry is murdered during a home invasion in a rented beach house, Gabe has no choice but to look into what happened that night. To solve Larry’s murder, Gabe, and the whole Ortiz family, must ask each other tough questions.

Music, radio and podcasts, all free. Listen online or download the iHeart App.

Connect

© 2025 iHeartMedia, Inc.