Today, I’m joined by Kiran Krishnan, a celebrated scientist best known as the innovative mind behind spore-based probiotics and someone who’s made waves in both the practitioner and consumer health spaces. In this conversation, Kiran shares what inspired his leap from the world of microbiome science into the realm of ancestral and Ayurvedic medicine—specifically, his groundbreaking work with novel bioactives derived from the Ashwagandha root.
To find out more, visit regenerive.co and use code NAT25 for 25% off.
Episode Timestamps:
Kiran Krishnan’s background and Regenerive overview ... 00:00:30
The promise and problems of herbal/Ayurvedic medicine ... 00:05:31
Ashwagandha: extraction, quality, and toxicity issues ... 00:11:02
Discovery of new Ashwagandha bioactives (ASHx4) ... 00:21:27
Preclinical and human clinical results (longevity, sirtuins, telomeres) ... 00:23:09
Physical and metabolic benefits in aging adults ... 00:48:33
Safety and dosing of Longfara supplement ... 00:57:38
Biohacks and healthy aging habits from Kiran ... 01:04:49
How to get Regenerive and wrap-up ... 01:07:32
Our Amazing Sponsors:
Tro Zzz by Troscriptions - This isn’t just melatonin—it’s a powerhouse! Oblipair gives you honokiol and agarin to enhance GABA binding, while adenosine and cordycepin boost sleep drive and deep sleep. CBD, CBN, and 5‑HTP round it out. Head to troscriptions.com, use NAT10, and get 10% off your first order.
NAD+ By Qualia - A groundbreaking formula that can increase NAD+ levels by up to 67%, using three of the most powerful precursors known to science: niacin, niacinamide, and NIAGEN. Go to qualialife.com/NATHALIE and use promo code NATHALIE to get 15% off—and try it risk-free with their 100-day money-back guarantee.
Manukora honey - From remote forests in New Zealand, where bees collect nectar from the native Manuka tea tree. That nectar is naturally rich in antibacterial compounds like MGO, plus antioxidants and prebiotics that support immunity and gut health. Visit manukora.com/NAT to save up to 31% plus $25 worth of free gifts with the Starter Kit - you’ll get an MGO 850+ Manuka Honey jar, 5 travel sticks, a wooden spoon, and a guidebook.
Nat's Links:
Stuff You Should Know
If you've ever wanted to know about champagne, satanism, the Stonewall Uprising, chaos theory, LSD, El Nino, true crime and Rosa Parks, then look no further. Josh and Chuck have you covered.
Cardiac Cowboys
The heart was always off-limits to surgeons. Cutting into it spelled instant death for the patient. That is, until a ragtag group of doctors scattered across the Midwest and Texas decided to throw out the rule book. Working in makeshift laboratories and home garages, using medical devices made from scavenged machine parts and beer tubes, these men and women invented the field of open heart surgery. Odds are, someone you know is alive because of them. So why has history left them behind? Presented by Chris Pine, CARDIAC COWBOYS tells the gripping true story behind the birth of heart surgery, and the young, Greatest Generation doctors who made it happen. For years, they competed and feuded, racing to be the first, the best, and the most prolific. Some appeared on the cover of Time Magazine, operated on kings and advised presidents. Others ended up disgraced, penniless, and convicted of felonies. Together, they ignited a revolution in medicine, and changed the world.
The Joe Rogan Experience
The official podcast of comedian Joe Rogan.