MeSsy with Christina Applegate & Jamie Lynn Sigler
On this podcast, Christina Applegate and Jamie Lynn Sigler get vulnerable about the curveballs that life can throw…theirs just happens to be MS. Join them each week as they self-reflect, learn, laugh, and grow through their own raw and often-times hilarious conversations with each other, friends, co-stars, and the people that keep them going through the messiness of life.
Episodes
February 17, 2026 • 63 mins
This week, Christina and Jamie read listener emails and discuss skincare products from childhood, crazy animal stories, not thinking too far into the future, and much more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
Wildgrain - Wildgrain is offering our listeners $30 off your first box - PLUS free Croissants for life - when y...
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February 10, 2026 • 55 mins
This week, Christina and Jamie read listener emails and discuss the Married... with Children reunion, catch up on their TV shows, Jamie opens up about a recent experience, and more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
Veracity - For up to 45% off your order, head to https://VeracityHealth.co and use code MESSY
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February 3, 2026 • 59 mins
This week, Christina and Jamie read listener emails and discuss MS fatigue, finding little moments of self care, how to better communicate with friends, and more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
Honeylove - Save 20% Off Honeylove by going to https://honeylove.com/messy #honeylovepod
Jones Road - Use code messy at h...
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January 27, 2026 • 62 mins
This week, Christina and Jamie are joined by Bobbi Brown. They discuss overcoming obstacles, how to elevate your mood, taking baby steps, and much more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
Lola - Get 40% off your entire order at https://Lolablankets.com by using code MESSY at checkout. Experience the world’s #1 blanke...
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January 20, 2026 • 47 mins
This week, Christina and Jamie read listener emails and discuss Jamie’s recent trip, pregnancy and MS, asking for help, and more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
Wildgrain - Wildgrain is offering our listeners $30 off your first box - PLUS free Croissants for life - when you go to Wildgrain.com/MESSY to start your s...
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January 13, 2026 • 63 mins
This week, Christina and Jamie are joined by Dr. Will Cole, a functional medicine expert. They discuss how to calm inflammation, medical gaslighting, the interactions between all our systems, and much more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
MudWtr - Start your new morning ritual & get up to 43% off your @MUDWTR with c...
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January 6, 2026 • 58 mins
This week, Christina and Jamie read listener emails and discuss repeat reality stars, being a mother with MS, not blaming yourself, and more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
Honeylove - Save 20% Off Honeylove by going to https://honeylove.com/messy #honeylovepod
Jones Road Beauty - Use code Messy at https://jonesro...
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December 30, 2025 • 60 mins
This week, Christina and Jamie read listener emails and discuss Christmas elves, setting goals, reclaiming your voice, and more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
Calm - Calm has an exclusive offer just for listeners of our show – get 40% off a Calm Premium Subscription at https://calm.com/messy
Ridwell - Go to ridwe...
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December 16, 2025 • 75 mins
This week, Christina and Jamie are joined by Meg Josephson, author of “Are You Mad at Me?: How to Stop Focusing on What Others Think and Start Living for You.” They discuss the fawn response, how to start healing, the importance of taking a pause, and more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
ZocDoc - Stop putting off ...
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December 9, 2025 • 78 mins
This week Christina and Jamie are joined by Montel Williams. They discuss his experience living with MS, bedside manner, why being ill doesn’t make you weak, and more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
Fatty15 - Fatty15 is on a mission to optimize your C15 levels to help support your long-term health and wellness -...
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December 2, 2025 • 56 mins
This week, Christina and Jamie read listener emails and discuss perspective, not stuffing your feelings down, journaling, and much more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
Nobl - Don’t miss NOBL’s biggest Sale of the Year! Head to NOBLTravel.com for up to 62% off your entire order! #NOBL #ad
Lola Blankets - Get 40% of...
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November 25, 2025 • 84 mins
This week, Christina and Jamie are revisiting their conversation with Deb Dana, LCSW, a clinician and speaker specializing in complex trauma. They discuss how to understand our nervous systems, polyvagal theory, how to feel safe in a body that may feel unsafe, and more.
Executive Producers: Christina Applegate, Jamie-Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This show is sponsored by:
Ridwell - Try Ridwe...
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November 18, 2025 • 67 mins
This week, Christina and Jamie read listener emails and discuss big feelings, reality dating shows, guilt, and more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
Zoc Doc - Stop putting off those doctors appointments and go to Zocdoc.com/MESSY to find and instantly book a top-rated doctor today.
MudWtr - Start your new morning ...
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November 11, 2025 • 71 mins
This week, we revisit conversations with three incredible guests: Edie Falco, Jean Smart, and Katey Sagal.
Executive Producers: Christina Applegate, Jamie-Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
Ridwell - Try Ridwell at ridwell.com/messy to get $10 off your first pickup or mail-in kit.Hollow Socks - For a limited time Hollow Socks is having a Buy 3, Get 3 Free Sale. Hea...
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November 4, 2025 • 61 mins
This week, Christina and Jamie are joined by Robert Iler, who starred on "The Sopranos" with Jamie. They discuss memories from their time on the show, his path to becoming sober, his friendship with Jamie, and much more.
Executive Producers: Christina Applegate, Jamie-Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
Ridge - Upgrade your wallet today! Get 10% Off @Ridge with code ...
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October 28, 2025 • 74 mins
This week Christina and Jamie are joined by Craig Thomas, an author and Co-Creator, Executive Producer and Writer of How I Met Your Mother. He shares his experience raising a son with Jacobsen Syndrome, discusses the power of storytelling to make people feel less alone, and talks about his new novel, “That’s Not How It Happened.”
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer:...
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October 21, 2025 • 57 mins
This week, Christina and Jamie read listener emails and discuss aging, being able to express emotions authentically, where to turn when you’re feeling stuck, and more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
Lola - Get 35% off your entire order at Lolablankets.com by using code Messy at checkout. Experience the world’s #1 b...
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October 14, 2025 • 65 mins
This week, Christina and Jamie read listener emails and discuss dynamic disability, not being alone in your struggles, the meaning we attach to things, and more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
Ridwell - Try Ridwell at ridwell.com/messy to get $10 off your first pickup or mail-in kit.
Mudwtr - Get up to 43% off you...
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October 7, 2025 • 51 mins
This week Christina and Jamie are joined by Baylen Dupree. She opens up about having Tourette syndrome, the importance of being yourself, why it's crucial to remember that everyone is struggling, and more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
Baylen's Beautifully Complex: https://beautifullycomplexbybaylen.com/
This episode is sponsored by:
Fatty1...
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September 30, 2025 • 61 mins
This week Christina and Jamie are joined by Megan Mullally. They discuss how her role as Karen on Will & Grace came to be, understanding family trauma, the comfort of TV, and more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
Calm - Calm has an exclusive offer just for listeners of our show– get 40% off a Calm Premium Subscripti...
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