MeSsy with Christina Applegate & Jamie Lynn Sigler
On this podcast, Christina Applegate and Jamie Lynn Sigler get vulnerable about the curveballs that life can throw…theirs just happens to be MS. Join them each week as they self-reflect, learn, laugh, and grow through their own raw and often-times hilarious conversations with each other, friends, co-stars, and the people that keep them going through the messiness of life.
Episodes
October 7, 2025 • 51 mins
This week Christina and Jamie are joined by Baylen Dupree. She opens up about having Tourette syndrome, the importance of being yourself, why it's crucial to remember that everyone is struggling, and more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
Baylen's Beautifully Complex: https://beautifullycomplexbybaylen.com/
This episode is sponsored by:
Fatty1...
Mark as Played
September 30, 2025 • 61 mins
This week Christina and Jamie are joined by Megan Mullally. They discuss how her role as Karen on Will & Grace came to be, understanding family trauma, the comfort of TV, and more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
Calm - Calm has an exclusive offer just for listeners of our show– get 40% off a Calm Premium Subscripti...
Mark as Played
September 23, 2025 • 51 mins
This week Christina and Jamie are joined by Christina’s friend, Cindy Locke. They share how they first connected online and discuss the impact of trauma, advice to people who are newly diagnosed, the importance of support, and more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
CBDistillery - If you’re ready for better sleep, les...
Mark as Played
September 16, 2025 • 55 mins
This week, Christina and Jamie are joined by Fraser Olender from “Below Deck.” They discuss what his job as chief stew actually entails, his journey to find his true self, the escape of being busy, and much more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
MudWtr -Start your new morning ritual & get up to 43% off your @MUDWTR w...
Mark as Played
September 9, 2025 • 56 mins
This week, Christina and Jamie read listener emails and discuss conditional friends, not identifying as the things that happen to us, staying honest, and more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
Fatty15 - Fatty15 is on a mission to optimize your C15 levels to help support your long-term health and wellness -Get an additi...
Mark as Played
September 2, 2025 • 69 mins
This week, Christina and Jamie are joined by Dr. Daniel Amen, a physician, double board-certified psychiatrist, and award-winning researcher. They discuss why pain can also live in your brain, the doom loop and how to get out of it, the cost of repressed emotions, and more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
Hexclad - ...
Mark as Played
August 26, 2025 • 62 mins
This week, Christina and Jamie read listener emails and discuss their kids starting the new school year, the power of manifestation, accepting reality, and much more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
Calm - Calm has an exclusive offer just for listeners of our show– get 40% off a Calm Premium Subscription at calm.com...
Mark as Played
August 19, 2025 • 59 mins
This week, Christina and Jamie read listener emails and discuss hormones, housewives, acknowledging the struggle, and more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
Sleep Number - It’s the Sleep Number's Biggest Sale of the Year. 25% Off the i8 Bed plus free home delivery. Limited time. Exclusively at a Sleep Number® store...
Mark as Played
August 12, 2025 • 87 mins
This week, Christina and Jamie are joined by Ed Helms. They discuss working together on "Vacation," his love of comedy, the importance of curiosity, and much more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
Lola - Get 35% off your entire order at Lolablankets.com by using code Messy at checkout. Experience the world’s #1 blank...
Mark as Played
August 5, 2025 • 69 mins
This week, Christina joins Jamie live from the hospital in LA. They discuss what Christina’s going through, her recent trip abroad, their upcoming memoirs, the way the universe works, and much more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
IRestore - Unlock your best hair & skin with @iRestorelaser and HUGE savings on the iR...
Mark as Played
July 29, 2025 • 71 mins
This week, Christina and Jamie are joined by Jenny Mollen, a New York Times bestselling author and actor. They discuss the feeling of not being in control, the trials of parenting, and more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
Honeylove - Save 20% Off Honeylove by going to honeylove.com/messy #honeylovepod
Mudwtr - Start your...
Mark as Played
July 22, 2025 • 64 mins
This week, Christina and Jamie read listener emails and discuss wins and losses, shows that are easy on the nervous system, why people don't understand invisible diseases, and much more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
O-Positiv - Take proactive care of your health and head to OPositiv.com/MESSY or enter MESSY at chec...
Mark as Played
July 15, 2025 • 72 mins
This week, Christina and Jamie are joined by Dr. Gretchen Hawley, an MS-certified specialist and physical therapist. They discuss what to do if you're feeling overwhelmed, the importance of staying consistent, why mindset is just as important as movement, and more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
Get the latest research from Doctor Gretchen here...
Mark as Played
July 8, 2025 • 60 mins
This week, Christina and Jamie read listener emails and discuss body work, Christina’s new obsession, and much more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
Fatty15 - Fatty15 is on a mission to optimize your C15 levels to help support your long-term health and wellness -Get an additional 15% off their 90-day subscription Star...
Mark as Played
July 1, 2025 • 88 mins
This week, Christina and Jamie are joined by Clea Shearer. They discuss how The Home Edit came to be, Clea’s breast cancer diagnosis, and the importance of fighting for your health and trusting your gut.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
Function - Function currently has a waitlist, but they are offering my audience t...
Mark as Played
June 24, 2025 • 73 mins
This week, Christina and Jamie read listener emails and discuss how connected our bodies are with our emotions, friendship heartbreaks, starting a family, and more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
Beam - Right now, Beam is offering UP TO 40% off their best-selling Dream Powder for our listeners. Perfect timing to lo...
Mark as Played
June 17, 2025 • 84 mins
This week, Christina and Jamie are joined by Judd Apatow. They discuss working on "Anchorman," parenting advice, spirituality, and much more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
Zoc Doc - Stop putting off those doctors appointments and go to Zocdoc.com/MESSY to find and instantly book a top-rated doctor today.
Magic ...
Mark as Played
June 10, 2025 • 61 mins
This week, Christina and Jamie read listener emails and discuss New York pizza, the trick to finding lost jewelry, how brain inflammation affects us, and more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
Fatty15 - Fatty15 is on a mission to optimize your C15 levels to help support your long-term health and wellness -Get an addi...
Mark as Played
June 3, 2025 • 62 mins
This week, Christina and Jamie are joined by Kaitlyn Bristowe. They discuss starting over, the impact of therapy, their love of dance, and much more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
BetterHelp - This episode is sponsored by/brought to you by BetterHelp. Give online therapy a try at betterhelp.com/messy and get on y...
Mark as Played
May 27, 2025 • 63 mins
This week, Christina and Jamie read listener emails and discuss being the “everything” friend, feeling validated in what you’re going through, finding support, and more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
Shop MeSsy merch: https://messypodcastmerch.giveswagger.com/messy_podcast_merch/shop/home
This episode is sponsored by:
BetterHelp - This epis...
Mark as Played
Popular Podcasts
If you've ever wanted to know about champagne, satanism, the Stonewall Uprising, chaos theory, LSD, El Nino, true crime and Rosa Parks, then look no further. Josh and Chuck have you covered.
Current and classic episodes, featuring compelling true-crime mysteries, powerful documentaries and in-depth investigations. Follow now to get the latest episodes of Dateline NBC completely free, or subscribe to Dateline Premium for ad-free listening and exclusive bonus content: DatelinePremium.com
The World's Most Dangerous Morning Show, The Breakfast Club, With DJ Envy, Jess Hilarious, And Charlamagne Tha God!
My Favorite Murder is a true crime comedy podcast hosted by Karen Kilgariff and Georgia Hardstark. Each week, Karen and Georgia share compelling true crimes and hometown stories from friends and listeners. Since MFM launched in January of 2016, Karen and Georgia have shared their lifelong interest in true crime and have covered stories of infamous serial killers like the Night Stalker, mysterious cold cases, captivating cults, incredible survivor stories and important events from history like the Tulsa race massacre of 1921. My Favorite Murder is part of the Exactly Right podcast network that provides a platform for bold, creative voices to bring to life provocative, entertaining and relatable stories for audiences everywhere. The Exactly Right roster of podcasts covers a variety of topics including historic true crime, comedic interviews and news, science, pop culture and more. Podcasts on the network include Buried Bones with Kate Winkler Dawson and Paul Holes, That's Messed Up: An SVU Podcast, This Podcast Will Kill You, Bananas and more.
The official podcast of comedian Joe Rogan.