MeSsy with Christina Applegate & Jamie Lynn Sigler
On this podcast, Christina Applegate and Jamie Lynn Sigler get vulnerable about the curveballs that life can throw…theirs just happens to be MS. Join them each week as they self-reflect, learn, laugh, and grow through their own raw and often-times hilarious conversations with each other, friends, co-stars, and the people that keep them going through the messiness of life.
Episodes
June 23, 2026 • 53 mins
This week, Jamie is joined by Summer House’s Mia Calabrese. She opens up about her journey with grief and what’s helped her to find joy again. They also discuss the Summer House scandal and Mia shares her thoughts on the reunion and bonus episode.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
Novartis in neurosc...
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June 16, 2026 • 51 mins
This week, Jamie reads emails from listeners. She also discusses mom guilt, PMS and MS, letting people know how their actions affect you, and much more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
Novartis in neuroscience - Our ambition is to create a transformational impact for people living with severe neurologica...
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June 9, 2026 • 65 mins
This week, we are revisiting conversations with some of our favorite Bravo men - Jesse Solomon, Carl Radke, and Andy Cohen. They share moments that were challenging, helped them grow, and changed their perspectives on life.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
Novartis in neuroscience - Our ambition is to create ...
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June 2, 2026 • 57 mins
This week, Jamie sits down with the one and only Aida Turturro. They reflect on their years together on The Sopranos, and Aida discusses living with rheumatoid arthritis since childhood, perspective, and finding gratitude during difficult times.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
Novartis in neuroscience - Our ambition i...
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May 26, 2026 • 51 mins
This week, Jamie reads listener emails and discusses what it means to feel seen, the complicated balance between grief and gratitude, and why you don’t have to be “perpetually positive” to keep moving forward.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
Novartis in neuroscience - Our ambition is to create a tra...
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May 19, 2026 • 73 mins
This week, Jamie is joined by Tony Award-winning actress and singer Lena Hall. They discuss being present in grief, the power of healing, finding your way back to yourself, and more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
Novartis in neuroscience - Our ambition is to create a transformational impact for people living ...
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May 12, 2026 • 73 mins
In honor of 'Marty, Life is Short,' we are revisiting our conversation with Martin Short. He reminisces, shares funny stories, discusses colonoscopy parties, and more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
Novartis in neuroscience - Our ambition is to create a transformational impact for people living with severe neurological conditions and their ...
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May 5, 2026 • 90 mins
This week, Jamie sits down with her therapist, Ana Maria Rodriguez, who is a licensed clinical mental health therapist and the founder and owner of Selva Wellness Collective. They discuss how she helped Jamie through processing what came up while writing her memoir, the way the body stores trauma, ketamine therapy, and much more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: ...
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April 28, 2026 • 63 mins
This week, Jamie is joined by her two best friends, Becca Tobin and Odette Annable. They discuss navigating friendships in all seasons of life, giving grace to yourself and others, finding your people, and more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
Novartis in neuroscience
Our ambition is to create a transformational i...
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April 21, 2026 • 65 mins
This week, Jamie is joined by her husband, Cutter Dykstra. They discuss his experience as her partner and caregiver, the role he's played in Jamie's acceptance and outlook, advice for other partners, and more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
Novartis in neuroscience - Our ambition is to create a transformational im...
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March 31, 2026 • 14 secs
We’re taking a short break for the next few weeks while Jamie and Christina focus on their book launches. We’ll be back soon with brand new episodes!
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March 24, 2026 • 73 mins
This week, Christina and Jamie are joined by Olivia Munn. They discuss Olivia’s breast cancer diagnosis, how she was finally able to shed her armor, why you shouldn’t tell someone going through something to look on the bright side, and more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
Veracity - Head to h...
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March 17, 2026 • 78 mins
This week, Christina and Jamie are joined by Carl Radke, Summer House cast member and host of "More Life with Carl Radke.” They discuss his journey to sobriety, holding in shame, forgiveness, behind-the-scenes of the show, and more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
Wildgrain - Wildgrain is offering our li...
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March 10, 2026 • 76 mins
This week, Christina and Jamie are joined by Jamie’s friend Ryan Weiss. They discuss how he helped her through a difficult time, the power of dance, emotional avoidance, why it’s so hard to look inward, and more.
Check out Ryan's course "How to Be Okay When Things Are Not Okay" and use code MESSY at checkout for 10% off
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Enginee...
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March 3, 2026 • 44 mins
This week, Christina and Jamie read listener emails and discuss the fragility of life, fighting against your body, and more,
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
Honeylove - Save 20% Off Honeylove by going to https://honeylove.com/MESSY #honeylovepod
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February 24, 2026 • 65 mins
This week, Christina and Jamie are joined by their friend Kelly Ripa. They discuss Kelly's career and how it began at a toy fair, the processing she had to do while writing her own book, the challenges of playing yourself on television, and much more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
Fatty15 - Get an additional 15% ...
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February 17, 2026 • 64 mins
This week, Christina and Jamie read listener emails and discuss skincare products from childhood, crazy animal stories, not thinking too far into the future, and much more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
Wildgrain - Wildgrain is offering our listeners $30 off your first box - PLUS free Croissants for lif...
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February 10, 2026 • 56 mins
This week, Christina and Jamie read listener emails and discuss the Married... with Children reunion, catch up on their TV shows, Jamie opens up about a recent experience, and more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
Veracity - For up to 45% off your order, head to https://VeracityHealth.co and use code...
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February 3, 2026 • 60 mins
This week, Christina and Jamie read listener emails and discuss MS fatigue, finding little moments of self care, how to better communicate with friends, and more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
Honeylove - Save 20% Off Honeylove by going to https://honeylove.com/messy #honeylovepod
Jones Road - Use code&...
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January 27, 2026 • 63 mins
This week, Christina and Jamie are joined by Bobbi Brown. They discuss overcoming obstacles, how to elevate your mood, taking baby steps, and much more.
Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick
Audio Engineer: Josh Windisch
This episode is sponsored by:
Lola - Get 40% off your entire order at https://Lolablankets.com by using code MESSY at checkout. Experie...
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