No Priors: Artificial Intelligence | Technology | Startups

No Priors: Artificial Intelligence | Technology | Startups

At this moment of inflection in technology, co-hosts Elad Gil and Sarah Guo talk to the world's leading AI engineers, researchers and founders about the biggest questions: How far away is AGI? What markets are at risk for disruption? How will commerce, culture, and society change? What’s happening in state-of-the-art in research? “No Priors” is your guide to the AI revolution. Email feedback to show@no-priors.com. Sarah Guo is a startup investor and the founder of Conviction, an investment firm purpose-built to serve intelligent software, or "Software 3.0" companies. She spent nearly a decade incubating and investing at venture firm Greylock Partners. Elad Gil is a serial entrepreneur and a startup investor. He was co-founder of Color Health, Mixer Labs (which was acquired by Twitter). He has invested in over 40 companies now worth $1B or more each, and is also author of the High Growth Handbook.

Episodes

A New Operating System for Physicians with OpenEvidence Founder Daniel Nadler

September 5, 2025 • 44 mins
How does a new technology get adopted by 40% of American doctors in just 18 months? In an era where the golden age of biotechnology has also created a dark age of physician burnout, OpenEvidence found the answer by fundamentally changing how doctors access critical information. OpenEvidence founder Daniel Nadler sits down with Sarah Guo and Elad Gil to discuss how his company solved the semantic search problem in medicine. He talks...
Mark as Played

Reshaping America’s Economy for the Superintelligence Century with Jacob Helberg

August 28, 2025 • 40 mins
AI doomers say that the technology will be the ultimate job-killer. But Jacob Helberg wants people to see AI as a tech that will boost, not replace, human workers and give them superpowers. Under Secretary of State for Economic Growth, Energy, and the Environment Jacob Helberg joins Sarah Guo and Elad Gil to talk about AI’s role in reshoring manufacturing in America, supply chain security, and transforming the US energy grid. He al...
Mark as Played

How Agentic AI is Transforming The Startup Landscape with Andrew Ng

August 21, 2025 • 42 mins
Andrew Ng has always been at the bleeding edge of fast-evolving AI technologies, founding companies and projects like Google Brain, AI Fund, and DeepLearning.AI. So he knows better than anyone that founders who operate the same way in 2025 as they did in 2022 are doing it wrong. Sarah Guo and Elad Gil sit down with Andrew Ng, the godfather of the AI revolution, to discuss the rise of agentic AI, and how the technology has changed e...
Mark as Played

Chips, Neoclouds, and the Quest for AI Dominance with SemiAnalysis Founder and CEO Dylan Patel

August 14, 2025 • 47 mins
What would it take to challenge Nvidia? SemiAnalysis Founder and CEO Dylan Patel joins Sarah Guo to answer this and other topical questions around the current state of AI infrastructure. Together, they explore why Dylan loves Android products, predictions around OpenAI’s open source model, and what the landscape of neoclouds looks like. They also discuss Dylan’s thoughts on bottlenecks for expanding AI infrastructure and exporting ...
Mark as Played

The Shifting Value of Content in the AI Age with Cloudflare CEO Matthew Prince

August 7, 2025 • 44 mins
Cloudflare has spent nearly fifteen years making the Internet faster, more reliable, and more secure. So now that AI systems are changing the way we interact with the Internet, Cloudflare wants to help level the playing field for content creators. Sarah Guo and Elad Gil sit down with Matthew Prince, co-founder and CEO of Cloudflare to discuss the evolution of the internet from search to AI, including Cloudflare’s role in facilitati...
Mark as Played

America’s Plan to Dominate the Full AI Stack with Sriram Krishnan

July 31, 2025 • 36 mins
Sriram Krishnan was never interested in policy. But after seeing a gap in AI knowledge at senior levels of government, he decided to lend his expertise to the tech-friendly Trump administration. Senior White House Policy Advisor on AI Sriram Krishnan joins Elad Gil and Sarah Guo to talk about America’s AI Action Plan, a recent executive order that outlines how America can win the AI race and maintain its AI supremacy. Sriram discus...
Mark as Played

The Power of Quality Human Data with SurgeAI Founder and CEO Edwin Chen

July 24, 2025 • 32 mins
In the generative AI revolution, quality data is a valuable commodity. But not all data is created equally. Sarah Guo and Elad Gil sit down with SurgeAI founder and CEO Edwin Chen to discuss the meaning and importance of quality human data. Edwin talks about why he bootstrapped Surge instead of raising venture funds, the importance of scalable oversight in producing quality data, and the work Surge is doing to standardize human eva...
Mark as Played

Asimov: Building An Omniscient RL Oracle with ReflectionAI’s Misha Laskin

July 17, 2025 • 62 mins
Superintelligence, at least in an academic sense, has already been achieved. But Misha Laskin thinks that the next step towards artificial superintelligence, or ASI, should look both more user and problem-focused. ReflectionAI co-founder and CEO Misha Laskin joins Sarah Guo to introduce Asimov, their new code comprehension agent built on reinforcement learning (RL). Misha talks about creating tools and designing AI agents based on ...
Mark as Played

Why Platforms Win and Point Solutions Fail with Rippling CEO Parker Conrad

July 10, 2025 • 44 mins
As a three-time founder, Parker Conrad has one piece of advice for aspiring entrepreneurs—don’t do it. The Rippling co-founder and CEO joins Sarah Guo to talk about what he learned from the crash at Zenefits, why most advice to founders is wrong, and how building a real platform—not a point solution—is the only way to win in SaaS. The two get into founder psychology, the myth of learning from failure, and what true ownership looks ...
Mark as Played

Chai-2: The AI Model Accelerating Drug Discovery with Chai Discovery Co-Founders Jack Dent and Joshua Meier

July 3, 2025 • 49 mins
AI has already fueled breakthroughs in biotechnology—but now, further advances in AI are poised to fuel pharmaceutical discoveries as well. Sarah Guo sits down with Joshua Meier and Jack Dent, co-founders of Chai Discovery, whose newly launched Chai-2 designs bespoke antibodies that bind to their targets at a jaw-dropping 20% rate. Jack and Joshua talk about the implications for Chai-2’s success rate at discovering antibodies for t...
Mark as Played

Meet AlphaEvolve: The Autonomous Agent That Discovers Algorithms Better Than Humans With Google DeepMind’s Pushmeet Kohli and Matej Balog

June 26, 2025 • 42 mins
Much of the scientific process involves searching. But rather than continue to rely on the luck of discovery, Google DeepMind has engineered a more efficient AI agent that mines complex spaces to facilitate scientific breakthroughs. Sarah Guo speaks with Pushmeet Kohli, VP of Science and Strategic Initiatives, and research scientist Matej Balog at Google DeepMind about AlphaEvolve, an autonomous coding agent they developed that fin...
Mark as Played

The Operating System for Self Driving Cars (and Tanks, and Trucks...) With Qasar Younis and Peter Ludwig of Applied Intuition

June 17, 2025 • 45 mins
When will fully autonomous vehicles see widespread adoption? According to Applied Intuition, that future is closer than you may think. Applied Intuition’s CEO, Qasar Younis, and CTO, Peter Ludwig, talk with Elad Gil about how now is the best time to both work on self-driving vehicle technology and monetize it. Qasar and Peter discuss the advantages of developing their own OS in-house for their autonomous applications, self-driving ...
Mark as Played

Will we have Superintelligence by 2028? With Anthropic’s Ben Mann

June 12, 2025 • 41 mins
What happens when you give AI researchers unlimited compute and tell them to compete for the highest usage rates? Ben Mann, Co-Founder, from Anthropic sits down with Sarah Guo and Elad Gil to explain how Claude 4 went from "reward hacking" to efficiently completing tasks and how they're racing to solve AI safety before deploying computer-controlling agents. Ben talks about economic Turing tests, the future of general versus special...
Mark as Played

Teaching AI to Understand the Physical World, with Dr. Fei-Fei Li of World Labs

June 5, 2025 • 35 mins
In this episode of No Priors, Sarah and Elad are joined by Dr. Fei-Fei Li, AI pioneer, co-director of Stanford’s Human-Centered AI Institute, and founder of World Labs. Fei-Fei shares why she’s building at the intersection of embodiment and intelligence, and what today’s AI systems are still missing. From the early days of ImageNet to her vision for the next generation of robotics, she unpacks the human and technical motivations be...
Mark as Played

AI Consolidation, Biotech Opportunities, and World Models with Sarah and Elad

May 29, 2025 • 25 mins
In this episode of No Priors, Sarah and Elad unpack the current state of the AI market - whether it’s consolidating, what’s enabling or blocking key mergers, and where the most promising untapped opportunities lie, particularly in biotech. They also explore the rise of world models and how AI’s novel methods for understanding complex systems may ultimately reshape how humans approach discovery and problem-solving.  Show Notes: 0:...
Mark as Played

AI is Making Enterprise Search Relevant, with Arvind Jain of Glean

May 15, 2025 • 31 mins
Arvind Jain joins Sarah and Elad on this episode of No Priors. Arvind is the founder and CEO of Glean, an AI-powered enterprise search platform. He previously co-founded Rubrik and spent over a decade as an engineering leader at Google. In this episode, Arvind shares how LLMs are transforming enterprise search, why most tools in the space have failed, and the opportunity to build apps powered by internal knowledge. He discusses how...
Mark as Played

Gaming as the Future of Education with Duolingo CEO Luis von Ahn

May 8, 2025 • 32 mins
On this episode of No Priors, Sarah talks to Luis von Ahn, founder and CEO of Duolingo, the world’s most popular education app with over 116 million monthly users and a market cap of approximately $17 billion. Controversially, it has recently committed to being “AI-first.” They discuss why motivation is the biggest challenge in education, how Duolingo harnesses game mechanics and behavioral insights to keep learners engaged, and th...
Mark as Played

O3 and the Next Leap in Reasoning with OpenAI’s Eric Mitchell and Brandon McKinzie

May 1, 2025 • 39 mins
This week on No Priors, Elad and Sarah sit down with Eric Mitchell and Brandon McKinzie, two of the minds behind OpenAI’s O3 model. They discuss what makes O3 unique, including its focus on reasoning, the role of reinforcement learning, and how tool use enables more powerful interactions. The conversation explores the unification of model capabilities, what the next generation of human-AI interfaces could look like, and how models ...
Mark as Played

Inside Deep Research with Isa Fulford: Building the Future of AI Agents

April 24, 2025 • 30 mins
On this episode of No Priors, Sarah sits down with Isa Fulford, one of the masterminds behind deep research. They unpack how the initiative began, the role of human expert data, and what it takes to build agents with real-world capability and even taste. Isa shares the differences between deep research and OpenAI’s o3 model, the challenges around latency, and how she sees agent capabilities evolving. Plus, OpenAI has announced that...
Mark as Played

Predicting the Earth with Josh Goldman: How KoBold Uses AI to Find Critical Minerals

April 17, 2025 • 40 mins
This week on No Priors, Sarah and Elad are joined by Josh Goldman, cofounder and president of KoBold Metals. KoBold is using AI to transform how we discover critical minerals like lithium and cobalt, making the exploration process faster, more precise, and more scalable than traditional methods. In this episode, Josh explains how KoBold is rethinking the fundamentals of mineral exploration by combining unique datasets, scientific m...
Mark as Played

Popular Podcasts

    On Purpose with Jay Shetty

    On Purpose with Jay Shetty

    I’m Jay Shetty host of On Purpose the worlds #1 Mental Health podcast and I’m so grateful you found us. I started this podcast 5 years ago to invite you into conversations and workshops that are designed to help make you happier, healthier and more healed. I believe that when you (yes you) feel seen, heard and understood you’re able to deal with relationship struggles, work challenges and life’s ups and downs with more ease and grace. I interview experts, celebrities, thought leaders and athletes so that we can grow our mindset, build better habits and uncover a side of them we’ve never seen before. New episodes every Monday and Friday. Your support means the world to me and I don’t take it for granted — click the follow button and leave a review to help us spread the love with On Purpose. I can’t wait for you to listen to your first or 500th episode!

    NFL Daily with Gregg Rosenthal

    NFL Daily with Gregg Rosenthal

    Gregg Rosenthal and a rotating crew of elite NFL Media co-hosts, including Patrick Claybon, Colleen Wolfe, Steve Wyche, Nick Shook and Jourdan Rodrigue of The Athletic get you caught up daily on all the NFL news and analysis you need to be smarter and funnier than your friends.

    The Joe Rogan Experience

    The Joe Rogan Experience

    The official podcast of comedian Joe Rogan.

    New Heights with Jason & Travis Kelce

    New Heights with Jason & Travis Kelce

    Football’s funniest family duo — Jason Kelce of the Philadelphia Eagles and Travis Kelce of the Kansas City Chiefs — team up to provide next-level access to life in the league as it unfolds. The two brothers and Super Bowl champions drop weekly insights about the weekly slate of games and share their INSIDE perspectives on trending NFL news and sports headlines. They also endlessly rag on each other as brothers do, chat the latest in pop culture and welcome some very popular and well-known friends to chat with them. Check out new episodes every Wednesday. Follow New Heights on the Wondery App, YouTube or wherever you get your podcasts. You can listen to new episodes early and ad-free, and get exclusive content on Wondery+. Join Wondery+ in the Wondery App, Apple Podcasts or Spotify. And join our new membership for a unique fan experience by going to the New Heights YouTube channel now!

    The Bobby Bones Show

    The Bobby Bones Show

    Listen to 'The Bobby Bones Show' by downloading the daily full replay.

Advertise With Us
Music, radio and podcasts, all free. Listen online or download the iHeart App.

Connect

Explore

iHeart

Live Radio

Podcasts

Artist Radio

Exclusives

News

Features

Events

Contests

Photos

Information

About

Advertise

Blog

Brand Guidelines

Contest Guidelines

Subscription Offers

Jobs

Get the App

Automotive

Home

Mobile

Wearables

© 2025 iHeartMedia, Inc.