De-Extinction, Dire Wolves, and Jurassic Park with Beth Shapiro

Can we bring extinct species back to life? Evolutionary biologist Beth Shapiro claims we just did. As Chief Science Officer at Colossal, her team made headlines in spring 2025 with the announcement of the de-extinction of the dire wolf. She takes us behind the headlines to explain how this is no “Jurassic Park” fantasy. She breaks down exactly how her team used ancient DNA, CRISPR genome editing, and the genomes of modern relatives to bring back lost traits and create animals capable of thriving in today’s ecosystems. Along the way, she dives into the surprising challenges of this work — from the quest for artificial wombs to the ethics of genetic engineering — and reveals how the same tools powering de-extinction are already helping endangered species survive. 

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Guest Bio: 

Beth Shapiro is an evolutionary biologist and Chief Science Officer at Colossal, a company notably responsible for the de-extinction of  the dire wolf. She is also a professor of Ecology and Evolutionary Biology at UC Santa Cruz. Her research focuses on species evolution and the continued impact of human activities, considering questions about domestication, speciation and pathogen evolution. She is also exploring techniques to recover trace amounts of DNA from samples and the possible role of genomic technologies in the fields of conservation and medicine.

Timestamps

(00:00) What is De-Extinction? Reviving the Dire Wolf

(29:45) Ethics and Backlash for Cloning 

(38:10) Modifying DNA to Bring Species Back to Life

(45:31) The Future of De-Extinction

(54:30) Credits