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November 26, 2025 49 mins

Sebastian Maniscalco is consistently one of the highest-grossing stand-up comedians in the country. With his Netflix special ‘Is It Me?’ and his autobiographical movie ‘About My Father’ co-starring Robert De Niro, he’s on the verge of finally becoming a household name. In this episode, Maniscalco opens up about doubling down on nostalgia and (mostly) avoiding controversy on stage. He also talks about how the comedy world has changed for better and worse since he got his start in the late ‘90s, shares stories from the sets of ‘Green Book’ and ‘The Irishman’ and explains how he decided to embrace the most embarrassing moment of his career on Jimmy Fallon’s ‘Tonight Show.’


This episode was originally published on December 6, 2022.


Follow Sebastian Maniscalco on Instagram @sebastiancomedy 

Follow Matt Wilstein on Bluesky @mattwilstein 

Follow The Last Laugh on Instagram @lastlaughpod


Watch full episodes of The Last Laugh podcast on the Daily Beast’s YouTube channel


Highlights from this episode and others at TheDailyBeast.com



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