This Week in Microbiology

This Week in Microbiology

This Week in Microbiology is a podcast about unseen life on Earth hosted by Vincent Racaniello and friends. Following in the path of his successful shows 'This Week in Virology' (TWiV) and 'This Week in Parasitism' (TWiP), Racaniello and guests produce an informal yet informative conversation about microbes which is accessible to everyone, no matter what their science background.

Episodes

October 11, 2025 53 mins

TWiM explains studies that show that the oral bacterial and fungal microbiome are risk factors for pancreatic cancer, and the gut microbiome and pyruvate metabolism of older adults are a link between sleep quality and frailty.

Hosts: Vincent Racaniello, Michael Schmidt, and Michele Swanson.

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September 12, 2025 48 mins

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August 29, 2025 59 mins

TWiM pays tribute to Elio Schaechter, former TWiM host, blogger, and microbiologist extraordinaire, then reviews the finding that Archaea produce peptidoglycan hydrolases that kill bacteria - a form of competition.

Hosts: Vincent Racaniello, Michael Schmidt, Michele Swanson and Petra Levin.

Guest Mark O. Martin.

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August 16, 2025 53 mins

TWiM discusses outbreak of Legionnaires disease in Harlem NY, an automated whole genome sequencing platform for bacterial strain typing in clinical microbiology laboratories, building E. coli with a 57-codon genetic code.

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July 31, 2025 64 mins

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July 19, 2025 55 mins

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July 4, 2025 50 mins

TWiM explains two strategies for bacterial competition for resources: by laying down a slippery lipid and pushing away competitors, or by breaking open cells with a spike, liberating essential nutrients.

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June 20, 2025 56 mins

TWiM describes how microbiological analysis of the Gowanus Canal in Brooklyn has revealed an antimicrobial resistance reservoir and bioremediation potential, and fungicide resistance in Fusarium graminearum, the fungus recently smuggled into the US.

Hosts: Vincent Racaniello, Michael Schmidt, and Petra Levin.

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June 6, 2025 58 mins

TWiM explains how a mutualistic model bacterium can become lethal in a non-symbiotic host, and engineering a kill switch into a tuberculosis vaccine for improved safety.

Hosts: Vincent Racaniello, Michael Schmidt, Petra Levin and Michele Swanson.

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TWiM explains a study of the unique and extreme microbial and chemical environment on the International Space Station, and the connection between the gut microbiome and pain in fibromyalgia.

Hosts: Vincent Racaniello, Michael Schmidt, and Michele Swanson.

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Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

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April 26, 2025 46 mins

TWiM describes isolation of a novel bacterial species isolated from the China Space Station, and how a chemical radar allows bacteria to detect and kill predators.

Hosts: Vincent Racaniello, Michael Schmidt, and Petra Levin.

Guest Mark O. Martin.

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Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

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April 11, 2025 53 mins

TWiM explains how to recode E. coli so it uses only one stop codon, and an exploration of the mechanisms of bacterial adhesion within dental plaque.

Hosts: Vincent Racaniello, Michael Schmidt, Petra Levin and Michele Swanson.

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Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

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March 17, 2025 54 mins

TWiM explains Pasteur’s relentless hunt for microbes in the air, and how bacteria hunt for prey by ixotrophy - using grappling hooks!

Hosts: Vincent Racaniello, Michael Schmidt, Petra Levin and Michele Swanson.

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Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

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February 28, 2025 46 mins

TWiM describes Shigella infection is facilitated by interaction of human enteric α-defensin 5 with a colonic epithelial receptor, and an amino acid change in RNA polymerase that leads to resistance to β-lactams by preventing dysregulation of amino acid and nucleotide metabolism

Hosts: Vincent Racaniello, Michael Schmidt, Petra Levin and Michele Swanson.

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TWiM explains the remarkable abilities of bacterial ice nucleating proteins to promote freezing of water, and cryoprotective proteins produced by worm microbiomes that prevent freezing.

Hosts: Vincent Racaniello, Michael Schmidt, Petra Levin and Michele Swanson.

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Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

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January 24, 2025 53 mins

TWiM explores the discovery of microbial enzymes, PETases, that can degrade ubiquitous plastics, and how exogenous peptidoglycan is a danger signal to trigger biofilm formation.

Hosts: Vincent Racaniello, Michael Schmidt, Michele Swanson.

Guest Mark O. Martin.

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January 10, 2025 41 mins

TWiM reveals that record high atmospheric methane growth has been driven by microbes, and the cecum as an adaptive niche for Salmonella typhi.

Hosts: Michael Schmidt, Petra Levin and Michele Swanson.

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Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

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December 26, 2024 62 mins

From ASMCUE 2024, the conference on undergraduate education, TWiM speaks with Becky, Melanie, and Katriana about their careers and how they use TWiM in undergraduate microbiology education.

Hosts: Michael Schmidt and Mark O. Martin

Guests: Becky Seipel-Thiemann, Melanie Melendrez-Vallard, and Katriana Popichak

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December 13, 2024 59 mins

TWiM describes how to make concrete more ‘green’ by using microbes, and bacterial bioluminescence as an important regulator of multitrophic interactions in the soil.

Hosts: Vincent Racaniello, Michael Schmidt, Michele Swanson and and Mark O. Martin.

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