All Episodes

September 30, 2025 28 mins

Welcome to What’s Up Docs?, the podcast where doctors and identical twins Chris and Xand van Tulleken untangle the confusion around every aspect of our health and wellbeing.

This week, Chris and Xand meet Dr James Rucker, a consultant psychiatrist at King's College London who is leading the European arm of a global trial of a psychedelic called psilocybin in a study designed to treat people with severe depression for whom other pharmacological treatments have failed.

The use of psychedelics in both traditional medicinal and spiritual ceremonies dates back thousands of years and examples include peyote and ayahuasca from Central and South America, Iboga root from Central Africa and LSD, which is synthesised from a fungus found throughout Europe. As the number of clinical trials involving psychedelics increases, scientists are cautiously optimistic that they may be able to help with a range of conditions from eating disorders and anxiety to depression and addiction.

If you want to get in touch, you can email us at whatsupdocs@bbc.co.uk or WhatsApp us on 08000 665 123.

Presenters: Drs Chris and Xand van Tulleken Guest: Dr James Rucker Producer: Jo Rowntree Executive Producer: Rami Tzabar Editor: Kirsten Lass Assistant Producer: Maia Miller-Lewis Assistant Producer and Researcher: Emily Bird Tech Lead: Reuben Huxtable Social Media: Leon Gower Digital Lead: Richard Berry Composer: Phoebe McFarlane Sound Design: Melvin Rickarby

At the BBC: Assistant Commissioner: Greg Smith Commissioning Editor: Rhian Roberts

A Loftus Media production for BBC Radio 4

Mark as Played

Advertise With Us

Popular Podcasts

Dateline NBC

Dateline NBC

Current and classic episodes, featuring compelling true-crime mysteries, powerful documentaries and in-depth investigations. Follow now to get the latest episodes of Dateline NBC completely free, or subscribe to Dateline Premium for ad-free listening and exclusive bonus content: DatelinePremium.com

Are You A Charlotte?

Are You A Charlotte?

In 1997, actress Kristin Davis’ life was forever changed when she took on the role of Charlotte York in Sex and the City. As we watched Carrie, Samantha, Miranda and Charlotte navigate relationships in NYC, the show helped push once unacceptable conversation topics out of the shadows and altered the narrative around women and sex. We all saw ourselves in them as they searched for fulfillment in life, sex and friendships. Now, Kristin Davis wants to connect with you, the fans, and share untold stories and all the behind the scenes. Together, with Kristin and special guests, what will begin with Sex and the City will evolve into talks about themes that are still so relevant today. "Are you a Charlotte?" is much more than just rewatching this beloved show, it brings the past and the present together as we talk with heart, humor and of course some optimism.

Stuff You Should Know

Stuff You Should Know

If you've ever wanted to know about champagne, satanism, the Stonewall Uprising, chaos theory, LSD, El Nino, true crime and Rosa Parks, then look no further. Josh and Chuck have you covered.

Music, radio and podcasts, all free. Listen online or download the iHeart App.

Connect

© 2025 iHeartMedia, Inc.