Most people who try to lose weight and keep it off end up failing. But what if the problem isn’t you - it’s the diet?
In this episode, we cut through the noise of weight loss fads to explore a science-backed method that’s helped countless people make real, sustainable changes. It’s called flexible dieting, and it’s built around the idea that personalised macronutrient targets, food quality, and consistency matter more than restrictive rules or trendy plans.
Our guest is Alan Aragon, a leading expert in fitness nutrition who’s spent over 30 years coaching clients and publishing research that’s reshaped how the industry thinks about fat loss. Alongside Alan is Professor Sarah Berry, ZOE’s Chief Scientist, who brings insight from her studies on metabolism and how our bodies respond to food.
Together, they unpack what actually works for long-term fat loss — and how you can get started with a realistic, effective approach that doesn’t require cutting out the foods you love.
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Timecodes
00:00 Forget crash diets
03:42 The REAL reason we're all gaining weight
10:50 Does the keto diet work?
13:15 High-carb or high-fat diet for weight loss
18:22 The biological reason you regain weight
19:26 What is the 'YOLO margin' and how can it help you lose weight?
22:53 How a single treat becomes a daily habit
24:22 The mindset trick to stop binge eating for good
27:53 How to turn your body into a metabolic engine
29:26 No.1 rule for PROTEIN intake
33:53 A surprising take on Ozempic
38:00 The hidden danger of weight loss drugs
39:23 Step one is NOT diet or exercise
42:02 Why poor sleep makes you crave junk food
47:50 Optimal protein for fat loss
49:07 The easiest way to hit your daily protein goal
51:17 The only 3 exercises you really need
53:58 How to do 80 squats a day without even trying
56:32 This simple eating trick can cut 15% of your calories
59:50 A final warning for anyone trying to lose weight
📚Books by our ZOE Scientists
The Food For Life Cookbook
Every Body Should Know This by Dr Federica Amati
Food For Life by Prof. Tim Spector
Free resources from ZOE
Live Healthier: Top 10 Tips From ZOE Science & Nutrition
Gut Guide - For a Healthier Microbiome in Weeks
Mentioned in today's episode
Resistance Training Combined With Diet Decreases Body Fat While Preserving Lean Mass Independent of Resting Metabolic Rate: A Randomized Trial
Effects of meal frequency on weight loss and body composition: a meta-analysis
Does Timing Matter? A Narrative Review of Intermittent Fasting Variants and Their Effects on Bodyweight and Body Composition
International society of sports nutrition position stand: diets and body composition
New insights in the mechanisms of weight-loss maintenance: Summary from a Pennington symposium
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Episode transcripts are available here.