What's Your Problem?

John Mills is the CEO and co-founder of a nonprofit called Watch Duty. His problem is this: How do you build an app to warn people when they are in immediate danger from a natural disaster? Watch Duty has millions of users and played a key role in the Los Angeles fires of 2025. In the show, John talks about how he built his app with the help of an army of volunteers, and why the government hadn’t already built something like ...

Josh Tyrangiel is the author of “AI for Good: How Real People Are Using Artificial Intelligence to Fix Things That Matter.” On today’s show, Josh talks about some of these real people and the problems they’re working on: a professor trying to understand her nonverbal son, a general who delivered millions of Covid vaccines in 2021, and a hospital CEO trying to reduce the rate of deadly infections. 

In th...

Betsey Stevenson is a labor economist at the University of Michigan, and she was an economic adviser to President Obama. Betsey’s problem is this: How can we create a world where the benefits of AI are broadly shared?

Betsey draws on history – including how the invention of household appliances created a crisis of meaning for American women – to understand how we should respond to the challenge of AI. And she sugg...

Maps have gotten much better over the past few decades. But they're still mostly two dimensional, and they struggle to keep up with a world that is always changing. Brian McClendon is the Chief Technology Officer of Niantic Spatial, a spinout of the company that makes Pokémon Go. Brian's problem is this: How do you build a three-dimensional map of the world that both robots and humans can use to find their way?

In this episode, Bri...

Dan Shipper is the co-founder and CEO of Every, a company that publishes newsletters about AI, develops AI-related software, and helps other companies use AI. Dan has two problems. One, how do you build a company where almost everybody has their own AI agent? And two, how do you use AI as a tool to improve your writing, rather than as a replacement for writing?

In this episode, Dan explains: 

• Why managing agents will be a...

The apples you can buy at the grocery store have gotten profoundly better over the past few decades. It’s a kind of everyday, hiding-in-plain sight innovation.  Kate Evans is an apple breeder and professor at Washington State University. Kate's problem is this: How do you invent a better apple?

With her team, Kate has in fact invented a new kind of apple called the Sunflare. It’s arriving in stores in a few years. She a...

Rob Meyerson is the co-founder and CEO of Interlune. Rob's problem is this: How do you help build an economy on the moon? Eventually, Rob hopes Interlune will help build a moon base. For now, he is focused on bringing a gas called helium-3 back from the moon to sell on earth. 

Earlier in his career, Rob was the president of Blue Origin, the rocket company founded by Jeff Bezos.

In this episode, Rob explains: 

•  Why re...

Aaron Edsinger left his job as director of robotics at Google to start a company called Hello Robot. Aaron’s problem is this: How do you build an affordable robot that people can use to solve real problems at home? The result is a robot that looks nothing like a person. In fact, it’s closer to a Roomba with an arm.

In this episode, Aaron explains: 

•  Why home robots have barely progressed since the Roomba
• Why s...

Ben Christensen is the co-founder and CEO of Cambium, the largest seller of salvaged wood in America. Ben's problem is this: How can we turn the trees that are falling to the ground all around us, into usable wood?

In this episode, Ben explains: 

• Why so much wood goes unused 
• Why Cambium created demand before building the supply chain 
• How building a data layer across the fragmented lumber industry reduces waste
...

Investors are pouring billions of dollars into nuclear fusion companies. The dream: transform human civilization (and power AI data centers) by providing cheap, abundant energy. But nobody’s figured out how to make it work yet.

What will it take to make fusion work at scale – and how will the world be different if it does? To answer this question, Jacob recently hosted a conversation at SXSW between Greg Piefer of SHINE...

Mark Barrocas is the CEO of SharkNinja, a company that sells everything from vacuums, to blenders, to beauty products. Mark’s problem is this: How do you invent new products that people want to rave about on social media? 

In this episode, Mark explains: 

• How SharkNinja finds product ideas
• The tradeoffs at the heart of product development
• How the Ninja Creami became a viral hit
• Why some products fail and others...

Michael Hufford is the co-founder and CEO of LyGenesis, a company working on a new treatment for end stage liver disease. Michael’s problem is this: How do grow a new liver inside the body of a sick patient?

In this episode, Michael explains: 

• The liver's unique power of regeneration
• The organ transplant crisis and how regeneration can help 
• The science behind using lymph nodes to grow new organs
• The status of ...

Rare earth elements are inside pretty much everything with an on-off switch: Phones, laptops, cars. Even missiles. And China controls the world’s supply of components made from rare earths.

David Abraham is the author of the book “The Elements of Power: Gadgets, Guns, and the Struggle for a Sustainable Future in the Rare Metal Age.” David’s problem is this: What should the US do about China's chokehold on th...

Ben Bloom is the co-founder and CEO of Atom Computing, a company building quantum computers out of individual atoms. Ben’s problem is this: How do you build a quantum computer that is actually useful for everything from discovering new medicines to building better batteries? 

In this episode, Ben explains: 

• The practical applications of quantum computers 
• Atom Computing’s approach using individual ne...

Jonny Dyer is the founder and CEO of a satellite company called Muon Space. The company’s first big project is a satellite constellation called FireSat.

Jonny’s problem is this: How do you  capture data from space to help manage wildfires around the world in near-real time? 

In this episode, Jonny explains:

• How smartphone tech inspired smaller, cheaper satellites.
• Why fighting wildfires is still shockingly pri...

After bacteria were discovered, it took scientists 200 years to figure out that they cause disease. If scientists had made the link sooner, hundreds of millions of lives could have been saved. 

In his recent book So Very Small, Tom Levenson, a professor of science writing at MIT, tells the amazing story of germ theory, and argues that our worldview can prevent us from seeing what is right in front of us – even when lives...

In recent decades, medical research has fundamentally changed how we think about heart disease. This fresh understanding has opened up new ways to prevent heart attacks. Eric Topol is a cardiologist and the founder of the Scripps Research Translational Institute in San Diego. Eric’s problem is this: How can doctors use recent technological developments to do a better job at preventing heart attacks?

See omnystudio.com/listener...