Reversing Alzheimer’s –The Bredesen Protocol and the Future of Brain Health

• In this transformative episode of Ageless and Timeless, host Michele Hughes sits down with Dr. Dale Bredesen, pioneering neurologist and New York Times bestselling author of The End of Alzheimer’sand The Ageless Brain. A globally recognized expert on neurodegenerative diseases, Dr. Bredesen shares why he believes ours will be the last generation to view Alzheimer’s as an incurable condition.Michele and Dr. Bredesen dive into:
• The science and success behind the Bredesen Protocol, including personalized, multi-factorial approaches to preventing and reversing cognitive decline.
• How early detection and cutting-edge diagnostic tools like the BrainScan blood test can dramatically shift outcomes.
• Real-life stories of recovery, including “Patient Zero,” who overcame early Alzheimer’s and is now walking across the U.S. to raise awareness.
• The seven core pillars of the protocol—from diet and detox to hormones and brain training—and the importance of addressing root causes such as inflammation, toxin exposure, and nutrient deficiencies.
• How lifestyle,genetic testing, and the role of microplastics and the gut-brain connection impact brain longevity. Dr. Bredesen also talks about the broader movement toward functional and integrative medicine and his work with Gray Matters clinics and Apollo Health to make this care more accessible. Whether you’re concerned about memory loss, caring for a loved one, or simply want to preserve your cognitive vitality, this episode is full of practical insights and hope for a healthier future.Resources & Mentions:
• Get a BrainScan–Non-invasive blood testing for early detection
• mycqtest.com–Free cognitive assessment and practitioner finder
• Apollo Health–Learn more about the Bredesen Protocol
• ApoE4.info–Community for individuals with the ApoE4 gene
• Judy Walks–Follow the inspiring journey of Patient Zero
  

Special Thanks: Dr. Bredesen for his decades of dedication and groundbreaking work in the field of neurodegeneration, and to all those continuing to fight for a brain-healthy future.

Medical Disclaimer –Ageless and Timeless PodcastAgeless and Timeless (the “Show”), along with its host and guests, shares insights and discussions on health, wellness, and longevity for informational and educational purposes only. The Show does not provide medical advice, diagnoses, treatments, cures, or preventative recommendations for any disease or health condition. The content shared should not be used as a substitute for professional medical advice, diagnosis, or treatment.While we strive to feature reputable sources and knowledgeable guests, neither Ageless and Timeless nor its host or affiliates assume responsibility for errors, omissions, or misinterpretations in the information provided. Listeners are encouraged to use their own discretion and consult with a licensed medical professional before making any health-related decisions. By listening to this podcast, you acknowledge that any actions you take based on the information presented are at your own risk, and Ageless and Timeless, its host, guests, and affiliates are not liable for any direct, indirect, incidental, or consequential damages resulting from the use of this content

Episode Transcript

Speaker 1 (00:09):
Good morning everyone.

Speaker 2 (00:10):
This is Michelle Hughes from Ageless and Timeless. Today, I
have a guest that I've been talking to for probably
nine months, but I've known about him for a couple
of years. His name is doctor Dale Gretison, and everybody
that's into the ending of Alzheimer's knows him because he
had a New York Times bestselling book, which I have

(00:32):
right here, the End of Alzheimer's.

Speaker 1 (00:36):
And so I don't know if I'm doing this right.
Is it in this? Is it in the video?

Speaker 3 (00:41):
A little? A little to your right, A little, yeah.

Speaker 1 (00:45):
The end of Alzheimer's.

Speaker 2 (00:47):
That is.

Speaker 1 (00:48):
Okay. So Dale, welcome. I'm so happy to have you here.

Speaker 2 (00:53):
And you know, I've been watching some of your podcasts
on on the internet, and one thing I have to
say right up front is you are truly on a mission,
and you're one of the most dedicated and most passionate,
but in a very subtle way. I mean, you don't
wear it on your sleeve, but you are truly a pioneer,

(01:16):
and you are truly doing something that is at the
cutting edge. And I will tell everybody right up front,
the first thing that Dale said to me after.

Speaker 1 (01:26):
Our get acquainted.

Speaker 2 (01:27):
Call that shocked me was he said, we will be Michelle,
we will be the last generation of people who will
look at Alzheimer's as an incurable disease. Well, that, coming
from probably one of the most disastrous records in history

(01:48):
of medicine for any disease.

Speaker 1 (01:51):
Is a bold statement, to say the least.

Speaker 2 (01:54):
So, Dale, why don't you just start off and tell
us what is it that makes you so courageous to
make a statement like that.

Speaker 1 (02:04):
Why do you think that can be?

Speaker 3 (02:07):
Yeah, that's a really good point, Michelle, And thanks for
having me on.

Speaker 4 (02:10):
In fact, we have here.

Speaker 3 (02:11):
So here's the new book, which is called The Rain,
which just became a New York Times bestseller. I agreed
that I'll get you a copy of that.

Speaker 1 (02:21):
Thank you. Well, you know we are neighbors, so it's
only a little.

Speaker 3 (02:29):
Right. So, what's what's changed dramatically during my career? And
I've been doing this now for fifty years. I'm in
my seventies, so this has been, you know, a lifelong passion.
As you said, when we started out, we were told
there's nothing you can do. There is nothing that will prevent,
reverse or delay cognitive decline. In fact, you know some

(02:51):
of the old work from from thousands of years ago.
Pythagoras pointed out, you know, dimension what happens to people
as they get old. Marcus Aurelius talked about what happens
to people as they get older, and until just the
work that we've been doing over the last ten years,
that was the thought, there's nothing that you can do.
As you get a little older, your mind slips, and

(03:14):
for many people they can look forward to dementia. But
as you pointed out, I did indeed say ours is
the last generation that will fear Alzheimer's because for the
younger generations, now what do they have? They have so
many things that we did not have. Number one, there
are new blood tests. Now there's something called brain scan

(03:34):
which gives you a pe tow two seventeen, GFAP and NFL.
That's three tests that literally look inside your brain and
tell you are you on the way to that problem,
and that there's a lot you can do about it.
Now we have labs you can look to see what's
driving it. Like never before, we can determine what is

(03:56):
driving you or whether it's you've got a little brain fall,
whether it's that you're really having trouble with your memory,
or you're having trouble recognizing faces, or getting lost driving
or remembering your keys, or any of these sorts of things.
We can now determine what's causing that problem, and it's
often multiple things. And of course COVID has been one

(04:19):
of the things that has contributed to so many people
having brain fog, but it's also the California fires, air pollution,
and leaky gut changes in oral microbiome. There are dozens
and dozens of things, chronic infections that people can be
unaware of, exposure to various toxins that they're unaware of.

(04:41):
We can ferret these out. We can identify and address
them like never before, and we have such spectacular results
with prevention and reversal of cognitive decline. We were the
first to publish that back in twenty fourteen. We're now
in the middle of a randomized can trolled trial at
six sites around the country and this will be completed

(05:04):
in October of this year. We have interim analysis to
see where we stand here. We're now about two thirds
of the way through and the results are really exciting.
So we are seeing statistically significant benefits for people who
are doing the right things, and the people who are
on standard of care are actually going downhill instead of
uphill as we know. So this really is a new

(05:27):
era like never before. We understand, and we can do
something about this so that we're getting to the point
that we can tell people, look, this is really an
optional problem. If you start early, get on active prevention
or early treatment, you can do very, very well. And
that was the point of the book The Ageless Brains

(05:47):
for all of us, whether you're headed for Alzheimer's or not,
let's optimize our performance and our protection of our brains.
Because whether you're twenties or nineties or anywhere in between,
your most important asset is a functional brain.

Speaker 1 (06:04):
You know, it's interesting because that little three pounds does
the work of, like you said, two thousand computers, and
people just take it for granted when they're young, and
I think even as we get older. You know, we're told.

Speaker 2 (06:17):
To get our livid checked, we're told to get our
hormones checked, you know, all these things that we have
to take responsibility for, but we're never told to go.

Speaker 1 (06:28):
Get our brain check.

Speaker 2 (06:29):
So how do you make this paradigm shift to get
people from being the creatures of habit, you know, and
as David Promoter quoted, and I think it was originally
an Einstein quoted, you know, doing the same thing over
and over again and expecting different results. Well, you know,
we've been led to believe that we can kind of

(06:50):
ignore the brain until.

Speaker 1 (06:52):
It's too late. Yes, how do we change that paradigm?
Doctor Gretison.

Speaker 3 (06:58):
Yeah, isn't that interesting? That's so important, And it stems
from the fact that people thought there was nothing you
could do about it, so they didn't bother to check.
So in fact, still mainstream medicine will say, don't bother
to check your apoe status, your genetics, because there's nothing
you can do about if you've got an increased risk
for Alzheimer's, there's nothing you can do about it. Well,
that's absolutely wrong, and in fact, people are doing something

(07:20):
about it all the time. So, you know, Michelle, the
very first person that I treated who got better, was
in April of twenty twelve and came out from Washington,
d C. She'd been having problems and she was actually
considering committing suicide because her doctor had already said you've
got early Alzheimer's. Her mother had died of it. She
had watched her mother in the nursing home. It was

(07:41):
really sad to see, and so she was actually saving
pills to kill herself. She came out and she was
sixty seven. Then she's done absolutely great. She's about to
turn eighty one, and she is now starting. She's by
the way, she's a brain health coach now and she
is starting on April fifth, a walk across the United

(08:03):
States to bring attention to the fact that there is
a lot you can do about brain health and about
prevention and reversal of cognitive decline. And she's been doing
it for thirteen years now. So she's going to be walking.
She's done one hundred mile bike rides and she's done marathons.
She's amazing, and she's going to begin to walk from

(08:24):
San Diego to Saint Augustine, Florida. No, it's going to
be it's a long way to walk, three five hundred miles.

Speaker 1 (08:33):
Is this patient zero from your booth?

Speaker 3 (08:35):
Patient zero, Judy. And so in fact, you can look
there's a website Judy Walks, and you can see you
can see her where she's going and where she is
at each stage of the game. I think it's a
wonderful story. But as you said, you know, we need
people to know about this now, We need able to
understand because so many times the doctor will just say

(08:58):
you're getting a little older. It's just what you expect,
and that is absolutely wrong.

Speaker 2 (09:04):
Right.

Speaker 1 (09:04):
Well, you you're obviously at the forefront of doing that
as his doctor, pearl mother being such a big believer
in being also you know, an expert in brain health.
So I have to tell you that although Ageless and.

Speaker 2 (09:21):
Times is only six years old, and that's you know,
that's a pretty good run for a podcast. But I
from the very beginning, had a mission to educate people
about brain health. I always felt the mission was to
help people generally speaking, that to you know, take charge
of their health. But I always felt like the problem

(09:43):
of seeing people, you know, to deteriorate from this horrendous disease
and might And by the way, my husband.

Speaker 1 (09:51):
I think I told you this. My husband was a football.

Speaker 2 (09:54):
Player and he developed Parkinson's without any genetics and any
So I'm very close to you know.

Speaker 1 (10:02):
This subject, and it's.

Speaker 2 (10:05):
Near and dear to my heart when I hear stories
like Gaudy you know what she's doing.

Speaker 1 (10:09):
Because I think that's this is all about it.

Speaker 2 (10:13):
It's just like taking anything that you want to create
brand awareness. This is like a brand, you know, curing
Alzheimer's the end of all sider And now how do
we get that awareness out to people? And it's a
little it's like baby steps. You know, you don't seem
to have these huge paradigms. You're certainly you and your
books have helped tremendously, and all your podcast lectures and

(10:37):
your lectures around the country, and in fact, you know,
I looked at Apollo Health and and you know, Deborah
Geisler's going to be on my podcast I think in
two weeks or three weeks so, and she's the you know.

Speaker 1 (10:54):
One of the founders with you of Gray Matters. Right,
So let's let's take a little.

Speaker 2 (11:01):
When backed up a little bit, what gives Alzheimer's? How
do you differentiate Alzheimer's from these other mental brain disorders?

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Speaker 3 (12:00):
Is a good point. So Alzheimer's was defined as a pathology.
So doctor Alzheimer way back in nineteen oh six, sover
one hundred years ago, had a patient who died who
actually got demented in her fifties, quite demented and passed
away and looked in the brain at that time saw
the hallmarks. By the way, another doctor, doctor Oscar Fisher,

(12:24):
right around the same time, also showed the same pathology.
So you know it's called Alzheimer's, it should probably be
called Alzheimer's Fisher disease, because they both did a superb
and very important work to define this and you could
see these these amyloid plaques, so it looks a little
bit like a drop of maple syrums on the brain.

(12:47):
You see these drops around and they are outside the
cells mostly. And then he saw also these shrunken neurons
with these tangled structures that he called neurofiblary tangles. What
they became called neurofibrillary tangles. And it's turned out that
these are associated with specific proteins. So those drops of syrup,

(13:10):
the amyloid plaques have turned out to be a little
peptide called beta amyloid, and so for years it was
thought that's what's causing the problem. We now know that
what happens is this is your brain's response to being
attacked by various microbes and various things. So what happens

(13:32):
is you have insults to your brain and your body
is trying, just as if you would get an abscess
in your tooth. You've got organisms there, but your body
is making all those white cells that are what's making
the abscess. They're doing it because they're trying to help you.
They're not trying. They're not there to hurt you. It's
the same idea with the amyloid, and then the one

(13:53):
that these neurofibrillary tangles. These are composed largely of what's
called phosphtao. And this is a fascinating story because tao
is a molecule that is a normal brain molecule, and
what it does is it bolts down your microtubules. So

(14:13):
you have these microtubules that are part of the structure
of your brain cells. So when you're growing these things
and reaching out and making new contacts and keeping memory,
just like putting an addition on your house, you need
to have the bolts the structure to keep that strong. Now,
what we've found in the research is that your body

(14:34):
literally just the way it goes from sleep to wakefulness
and all whole sort of things change. In going from
sleep to wakefulness, you also go from connection mode to
protection mode. When things are good, you are putting your
resources into connections, so your tao is bolting down these

(14:56):
things you're making and keeping these structures. When you've got inflammation,
when you've got organisms there, when you've got toxin exposure,
all these sorts of things, your brain literally switches from
connection mode to protection mode. When it does that, your
tau is phosphorylated, so you add phosphorus and oxygen to

(15:19):
your tao and what it does is it changes the
charge and the shape, so it pops off. Unfortunately that
allows your neurrites to collapse again, but it now goes
and it kills bacteria. So it's literally becoming an antimicrobial protein.
And you're by the way, your amyloid is an antimicrobial

(15:41):
peptide short piece of a protein. So it's clear that
when you get this problem, you are responding to insults.
And as you imply there there is an intimate relationship
between brain aging and Alzheimer's and people have always argued,
you know, is it separate, is it the same? You
know what's going on here? Well, it turns out it

(16:02):
is closely related. That's why it's hard to separate the two.
So you do get this amyloid in your towel as
for many people as they age, but you may not
have dementia. This is why it's so important for anyone
to get for everyone to get evaluated. And by the way,
I just had my own tests done so everyone should know.

(16:24):
They're what we call brain scan. It's a blood test
for p TOW for it's called PTOW two seventeen because
it's the one that correlates best GFAP, which tells you
whether there's inflammation in your brain, and then NFL which
tells you if there's damage to your neurons. These are
three complementary tests that are absolutely critical and you get

(16:47):
the little report that will show you. So you can
go to get a brain scan dot com. You can
actually have it drawn. I had it drawn in my kitchen.
I don't do it with mobile phlebotomy. You can do
it by going to a local draw station. Lots of
ways to get the done. So it's a very helpful test.
And so for the first time we can look without
having to get to a spinal tap. We can look

(17:09):
inside your brain with a simple blood test, see where
you stand, and then we can address the things that
are actually causing the decline. So Alzheimer's is a pathology,
but it's been argued about what actually causes that. When
you get it, by the way, you go through four phases,
so you actually have a long time where you can

(17:29):
prevent and reverse this problem. Phase one asymptomatic. You don't
know you have problems, which is why early testing is
so important. Phase two sci subjective cognitive impairment. By definition,
you notice something's not quite right, but you're still able
to score normally on cognitive testing. Phase three is MCI

(17:51):
mild cognitive impairment, where now you are struggling on the test,
but you're still able to care for yourself. And in
phase four, unfortunately, dementia, where now you're having trouble with
your activities of daily living. We find that in the
first two phases we can get one hundred percent of
the people to do very well. Phase three, in our trial,

(18:12):
eighty four percent of the people improved, but some of
them approved a lot, some of them proved a little.
And phase four, the dementia, we do see people improve,
but it's hard to bring them all the way back
to normal, which is why again we want people get
in early, get checked early. Let's make sure you never
get to those phases three and four.

Speaker 2 (18:31):
So do you need a doctor's prescription to get a
brain skin dot com No.

Speaker 3 (18:36):
So one of the things that we're involved in is
trying to make this war available for everybody, make it
so people can get appropriate labs, and then you can
get a brain health coach. You can find a doctor
who's been trained. We've trained over two thousand physicians all
over the world and all over the US to be
able to do this, and we do see big differences

(18:57):
between people who are trained and who know what they're
doing and people who haven't been trained, so that you
can get very good outcomes for many doctors. So yeah,
you don't have to have your doctor do this. You
can get this online easily. And so we want to
make this available so everybody can have the best chance
of good outcomes in their cognition.

Speaker 2 (19:19):
And isn't this what Gray Matters is trying to do
with respect to spreading, you know, expanding into different cities
so that people can actually go to a physical location.

Speaker 3 (19:34):
Yes, And because there are so many people that you know,
they go to their doctor and the doctor says, well,
I don't know about this, I don't know how to
do it. I don't know what to look for. I'll
just tell you the standard The standard line is, uh.
You know, the party line is there's nothing you can
do about it, so, you know, so they don't believe it.
So Gray Matters, as you mentioned, founded by Deborah Geisler

(19:56):
and Craig Weston and Howard Byrd and myself, UH, is
to spread clinics around the country to say there is
something you can do about it. We see it again
and again. We've published trials showing that you can improve
and everybody should have access to best cerebral care. So
and and deb has been fantastic. She has a long

(20:17):
history with healthcare at Harvard and has done a great
job in setting this up.

Speaker 1 (20:23):
So what's stay vision is Right now, they're only in Florida, correct,
and they have three.

Speaker 3 (20:31):
Locations right So the vision is to have clinics all
around the country that will make it so that people
can get on prevention and active you know, and active treatment.
And you can do that today through Apollo and through
getting someone who's who has been trained. That's I think
the best way to go. But there's not yet these

(20:52):
standardized clinics where you can where you can know, here's
someone that's been been trained. So the best thing right
now you can definitely get get the brain scan, get
the blood tests and look and it will tell you,
and then get a good practitioner who has been trained.
We hope that there will be clinics around the country
at some point.

Speaker 1 (21:13):
To help you do that.

Speaker 3 (21:14):
And now in Florida, doctor Neilds is the doctor there
who's doing an excellent job with patients but the one thing,
you know.

Speaker 2 (21:22):
If you can go get the test on your own
without a doctor, but somebody has to interpret the results.

Speaker 3 (21:28):
So there is a report that actually interprets the results
for you. And then there's also you can there's a
number you can call up and you can get further discussion.
You can get so all the things that you need
you can get. We want to make this so it's
easily available to everyone.

Speaker 2 (21:44):
Right, but you don't see patients, but yet you have these,
you know, eighty four percent of these and those seven
people that wrote the second book, so obviously you did
treat you know, you've made some ecces.

Speaker 1 (22:00):
When do you make an exception to actually take care
of a patient?

Speaker 3 (22:05):
Yeah, so you know I was you know, I saw
patients for years and but but then I ran a
laboratory for years so that we could study the basic aspect.
So the idea is we went into the lab with
the idea that there was nothing at that time. This
has now started my first lab in nineteen eighty nine,
and so there was nothing that could be offered to anybody.

(22:26):
So I thought, it doesn't help me to tell people
there's nothing that I can offer you. So the idea
was to go into the lab study this at the
most basic level, see if we could understand the process
well enough to begin to fashion the first effective treatments.
We did that, and so I actually did see patient zero,
and I've seen a number of patients since then. But

(22:48):
I'm not a I'm no longer a you know again,
as I said, I'm in my seventies. Now I'm no
longer a clinically practicing physician. So now I'm a teacher.
So we have taught all these people how to do this,
and many of them are doing a fabulous job. We're
developing new tests and I'm involved with that, looking at
what can we do better, how can we do it less?

(23:08):
And basically, how can we do all the things that
are needed. What are the tests that are working, what
are not working, what are the treatments that are working.
There's a lot of junk out there, as you know.
People will say, oh, you just take my crystal and
put it on your forehead, Everything's going to be fine. No,
we want to know the things that are actually scientifically
validated and working. I'm not seeing many people these days.

Speaker 2 (23:33):
So do you have a data do you have a
database of the two thousand people you've trained, so that
people can look at their geographic location and find someone
that's a specialist and have learned through through your training.

Speaker 3 (23:46):
Yeah, and in fact that you know, the easiest way
to get onto that is to go to my CQ test.
So CQ is cognitive quotient, So m y CQ test.
That gives you a free online cognitive assessment. Yeah, and
look and see where do I stand?

Speaker 1 (24:05):
Do I?

Speaker 3 (24:05):
Because this does sneak up on you as you know
some changes in your cognitive abilities. You can do that
and you can also will help you get the appropriate
tests and tell you where are the trained practitioners.

Speaker 1 (24:18):
Somebody's trying to call in. So you just got into
put it up into a little box. So hold on
just a second. I'm sure you can come back. As
soon as that call goes away. There we go. Okay,
we're back. Okay, So that's really good. This is you know,
one of the things I wanted to do.

Speaker 2 (24:35):
In today's podcast is have practical information for people to
be proactive that they get inspired by what they learn,
or if they.

Speaker 1 (24:45):
If they just read your book twenty seventeen, you know
that's seven years ago, eight years ago. What has changed
in the eight years that you want to share with us.

Speaker 3 (24:59):
Yeah, really good point. So in the eight years since
the first book came out, this is why I wrote
the new one, The Ageless Brain. And so number one,
we've never had these blood tests before, so this is
this one that I mentioned brain scan that's never been
available before, so that you didn't really know. You had
to have a spinal tap, or you had to have
a very expensive pet scan instead of just a simple

(25:21):
blood test. So to me, that is a huge step
in the right direction, and you could also use that
to follow where you stand as you get better. The
second thing, when we first came out with this back
in twenty seventeen, we had anecdotal improvements, but we didn't
have a clinical trial. There are now three clinical trials,

(25:43):
all showing two of them already published. The next one
will be published later this year, all showing the same thing,
improvement when you address these things that are driving the problem.
The third thing is we understand much more now about
the drivers of the disease. We had the thirty six
holes before you we're looking at all these different pieces.

(26:04):
We now know that they all come in just a
couple of groups. So we can look for them better
and we can address them better. We know more things
like EWOT, which I didn't know about way back when,
which is exercise with oxygen therapy. It's actually quite helpful
for people because it gives you this double positive. You've

(26:24):
got better blood flow with better oxygenation. We know a
lot more about how to achieve best outcomes. We know
more about some of the pathogens that can be involved
with this, so we have a better and better chance
to produce this. Also, in twenty seventeen, we didn't have
any examples of long term improvement because we didn't we

(26:47):
hadn't been doing it long enough. We've now published a
paper it's freely available online that shows sustained improvement in
people for over a decade. As I mentioned, first patient
came in in twenty twelve, so she's now thirteen years out.
She's doing great, So we now know about long term outcomes.
We've now begun to modify this and use it for

(27:12):
other neurodegenerative conditions. We have some good results with Louis
body disease, which is often mistaken for Alzheimer's disease. We
have some beginning good results with macular degeneration. We have
some beginning results with Parkinson's, so there are other things
that as we understand the process better, we can do

(27:33):
better and better for outcomes. We now have a much
bigger group of people who've been trained to do this,
but there's still a lot more to do. We need
to understand how to make this as simple as possible,
as accessible as possible, as effective as possible. And one
of the big problems has been mainstream medicine saying, hey,

(27:57):
what are you talking about. We know you can't do that.
You know, it's interesting to me when you have something
that hasn't been done before. People will literally deny data.
Yeah data, Well, you have to get the word out.

Speaker 1 (28:11):
If it makes you feel any better.

Speaker 2 (28:13):
I was on the board of doctor Barry Sears and
doctor Stephen Sinatra.

Speaker 1 (28:18):
I don't know if you know them, but Barry Sears
was the.

Speaker 2 (28:21):
Really the father of inflammation, of the concept of inflammation,
and he developed the zone diet and he wanted he
and doctor Sinatra, who was a big famous cardiologist, wanted
to expand by creating these little zone cafes.

Speaker 1 (28:39):
Yeah.

Speaker 2 (28:39):
Interesting, And they did one prototype in Reno and it
was so successful. Anyway, but the point I'm making that
I was on their advisory board because I knew even
a couple of the people other people that were involved,
and they wanted someone with real estate and a passion
for health. You couldn't find someone that fit that one

(29:02):
as well as I could at that moment, because I
was developing real estate all over the far, you know,
in many locations, and some of which the locations they wanted.
But I remember sitting down with doctor Sears one day
and he said, it is so frustrating because I know
that inflammation is the root cause of so many diseases,

(29:23):
but I am getting so much flack from my own
medical community. And now I think of you and how
you said many of your friends don't even talk to
you anymore.

Speaker 1 (29:34):
So what is it?

Speaker 2 (29:35):
Why is it that this disease has just basically snookered
so many famous brain I mean, you know, really bright
people into thinking that it's a mono cause you know, basically.

Speaker 1 (29:51):
Beta amyloid is the cause. They don't really.

Speaker 2 (29:56):
Think beyond and embrace possibility that are outside of that paradigm.
So why do you think there is so much resistance
to your actually very credible research and data, Like you said.

Speaker 3 (30:12):
Yeah, yeah, there are a lot of angry people out there.
It's so funny. So, you know, two centuries ago, in
the early eighteen hundreds, there was no germ theory. People
didn't know about microbes, about bacteria and things like that,
but they knew that women were dying. Women in Europe
were dying when they after they had their babies, and

(30:34):
they would get infections and die. They didn't realize what
it was. And so a doctor, a young doctor named
doctor Ignaz Semmelweiss, said, you know, there must be something
associated with the fact that the medical students who were
delivering the babies worked on cadavers before they would deliver
the babies.

Speaker 1 (30:52):
Oh wow.

Speaker 3 (30:54):
And so, as it turned out, they were carrying infections,
unfortunately from the cadavers, and so many women would die
after childbirth with what they call purporle fever. So he said, look,
you guys have to use this solution that he developed
for cleansing your hands. And the rate of death from
mothers went down. In fact, a couple of months, it

(31:16):
was completely zero, whereas it had been up very very high.
You know, twenty thirty thirty five percent of these people
were dying. It was horrible. So he said, Okay, there's
something in there. I don't know what it is yet,
but this this is the beginning of what later would
become germ theory and List and Pastor and all these people.

(31:36):
At the time, the doctors who are the quote experts
pushed back so hard he ended up being forced to
go into an insane asylum ideas where he died of
an infection. Ironically, oh, we doctors have a horrible track
record of coming into the modern times. And it's because,

(31:58):
you know, being a doctor is like being in the army.
You're told if you don't do what we tell you,
someone might die, just like the army, So you do
what you're told, you don't ask questions. Well, when you
have something like Alzheimer's where there's nothing, somebody's got to
ask questions, and so you now have to start looking
at what's better now. To be fair, the data that

(32:20):
support Alzheimer's as a mediator, not the cause of the problem,
but as an important mediator are pretty good. I mean
they're very good, actually, and it's because people who have
mutations in that gene amyloid precursor protein do go on
to get Alzheimer's so there's no question you can give
someone Alzheimer's, which is what they do in the mice

(32:43):
by making a bunch of extra ameloid, but that doesn't
say that that's the cause of it. Yeah, majority of people,
and that's our research was over the years, what's driving
this problem? And you can see that this is literally
a network insufficiency. You just like a big company or
a big country. You've got all these things that have

(33:03):
to work together to get things working. And we start
reducing the energy, reducing the blood flow, reducing the oxygenation,
all these things. And now you add more demand, which
is inflammation. Now you got to deal with infections, toxicity.
Now you've got a detox. You lose that you cannot
support the five hundred trillion synapses in your brain.

Speaker 2 (33:28):
You know, I'm so happy, Yeah, and Charity interpret and
so happy you said that words because I don't know
that everybody understands what a synapse is.

Speaker 1 (33:37):
Would you define that? Yeah?

Speaker 3 (33:39):
Absolutely, So. The way your brain works, it's very much
like a computer where you've now got a you've got
an impulse, which is going from one place to another
and then basically making decisions whether you're going to basically yes,
or no. So a synapse is where the brain cells connect.
They come very closely, don't touch, they come very close,

(34:02):
and then across that tiny little junction of the synapse
they spray a little neurotransmitter and so then depending on
the strength of the inputs you get, basically will fire
the next neuron or you don't fire it. So it's
essentially a way to build a computer. And as you
said earlier, it's amazing. We can store in our brains

(34:29):
over two thousand home computers worth of information. So imagine
having two thousand computers in your home. All of that
storage capacity is in your brain. So when you are
unable to support all of that, you've got a downsize. Unfortunately,
just like a company, you do not support it. And

(34:51):
when you've got additional demands on it because of infections, inflammation, toxicity,
you're also going to have to downsize. Said earlier, you're
switching your resources from connection to protection. And that's what's
happening in Alzheimer's. And if you don't identify it and
address it, you just keep downsizing, downsizing, downsizing, till you

(35:14):
can no longer take care of yourself. So this is
a breakthrough in our understanding about what this is all about,
and we got to quit saying, well, it's just amyloid. Well,
the amyloid is there for a reason. So we're changing
the way we think about this. From pathology amyloid how

(35:34):
tangles things like that to physiology, what is your body
doing to try to help you give it the insults
it's undergoing. When you do that, it really opens things up.

Speaker 2 (35:46):
That is such an important statement that you just made
from pathology to physiology because you know, app as you
mentioned in your book, you know, they that amyloid is
actually the protector and to get it so wrong, you know,
the whole medical establishment has gotten it so wrong and

(36:07):
spent how many millions or billions that have been spent
on this disease.

Speaker 3 (36:12):
Over forty billion dollars and still no cure. That's a
big mistake. That is an expensive mistake.

Speaker 2 (36:20):
And still no cure except the Bretison Protocol, which they're
ignoring or not or not willing to embrace. So this
is a sad story, and you know, it kind of
reminds me a little bit of your history with the
Buck Institute and where it was when I think you
were probably the person that was serving because you were

(36:40):
the founder of founding CEO, and that's when I was
on their advisory board, was right.

Speaker 1 (36:46):
At the very beginning.

Speaker 2 (36:47):
So we must have known each other back then, but
not really you know, remember that. But I can remember
the Buckans started out being very allopathic and very much medded,
wedded to the pharmaceutical industry.

Speaker 1 (37:03):
And I don't want to get into the.

Speaker 2 (37:04):
Politics, but I remember thinking very feeling very uncomfortable. And
to your credit and to Lee Hood and Eric Verdon,
both of whom, well, Lee was supposed to be on
my podcast. He will be on, I hope next year,
but Eric has already been on. Eric wants me to
interview doctor Nathan Price. So I'm getting a lot of

(37:27):
exposure to the Buck Institute for where they are today,
and you were the you know, the first and foremost
to really start them on that track of embracing something
that now we look at with respect to a specific
condition called Alzheimer's and other neuro degenerative diseases that actually

(37:51):
embraces the very protocol and functional medicine, integrative medicine structure
that the Buck Institute basically started to move towards, and
over these years have gotten more and more to that
level of let's call it away from pathology and more

(38:15):
towards physiology.

Speaker 1 (38:16):
So that all that being said, the.

Speaker 2 (38:19):
Reason I'm saying it is because I want you to
take a deep dive into the functional medicine protocol, which
is really the Breteston protocol. So let's start with those
seven pillars that are the real coustitive factors. For let's
just use Alzheimer's even though it can be embracing other

(38:41):
neurogener degenerative diseases.

Speaker 3 (38:44):
Yeah, and as I mentioned, we're you know, we're modifying
this to take into account the special situation for each
of these different networks. So whether it's Louis body related
or whether it's als related or magic generation. So yeah,
so we're all about best outcomes. That's that's the goal.
And so it's this is why the Institute has moved

(39:04):
toward this with people like Lee Hood and Nathan Price.
They are experts in this area. So we're looking at
all the things and they're they're very good with things
like metabolomics and and as as Lee calls it, the theenome,
we don't want to just look at the genome. We
want to look at the theenome to see where things stand.
So we we are we start with, you know where

(39:26):
the brain scan that I mentioned earlier, you were going
to get that and look at what's the status of
your brain. Then we look at the future where are
you headed? And that includes things like your homocysteine and
your hsc RP and your various tocsin burden, all these
sorts of things. And then we can fashion a personalized
precision medicine protocol for you which addresses these various things.

(39:49):
And as you said, there are seven basics and there
are two specifics. And the way this works is the
basic things support everybody the specific things. Then say you
have additional things we need to look at. So seven
basics are this so interestingly your diet. You know everyone
thinks diet is not very important, doesn't really matter what
you eat. As an I was taught, diet's not that important.

(40:13):
Have to be very incorrect. So much that can be done.
So a plant rich, mildly ketogenic diet with high fiber,
high phyto nutrients very very important. Arguably the most important
of all these things. Healing your gut, making sure that
your gut microbiome is good, having enough prebiotic fiber, all

(40:34):
this sort of stuff. Exercise, and there's some great things
like ewat that I mentioned, Katsu bands hit this high
intensity increases your BDNF, which we know supports synapse formation
and has an anti Alzheimer effect. It's a very good one.
And then the third one is sleep and I tract

(40:56):
mine every night. It's an idea. You want to have
sleep each night, at least seven hours of sleep, at
least an hour and a half of rem at least
one hour of deep sleep, and at least ninety four
percent oxygen saturation. Those are parameters critical and having good
you know sleep hygiene is helpful and things like this.

(41:18):
And then the fifth thing is brain stimulation. And as
you are supporting your brain, you want to stimulate it
a little bit too, and that's with brain training, it
can be with photobiomodulation, you know, red light therapy, things
like that very helpful. And then detox some basic detox
for all of us, sauna sweating, non toxic soaps to

(41:41):
get rid of that sweat afterwards, basic detox, clean water,
you know, filtered water. These are all very helpful and
as you know, one of the big things that is
coming up now is the microplastics. Can't ignore these anymore.
It turns out they do collect your brain more than
your liver. They concentrate in your brain more, deliver more

(42:05):
than your kidney, and they are associated. We don't know
yet whether it's causal, but they are clearly associated epidemiologically
with cognitive decline. Now you can reduce these with things
like plasma exchange. That's expensive and like somebody going to
have to undergo plasma exchange, we've got to look at

(42:27):
better and better ways to minimize the microplastics in our brain.

Speaker 1 (42:32):
Right classmic exchange.

Speaker 2 (42:33):
If you go to doctor dog Schawan Shaw nextl it's
like eighteen thousand dollars. If you go to doctor Kurita
in Florida, he's a lot less, but it's like four
or five thousand. At the A four m oh No
at Radfest they were doing actually had someone right on
the floor that was doing it, set up their booth
and everything, and that was going to be about six thousand.

Speaker 1 (42:56):
So this is not affordable for everybody, but it is you.

Speaker 2 (42:59):
Know, certainly if you can afford it to take four
or five meters of your blood out of you and
basically reconstitute it with oxygenation, taking out all the toxicity,
and they even show.

Speaker 1 (43:15):
You the blood is the color of the blood and
how it changes. It's something it's really quite fascinating.

Speaker 2 (43:21):
But not everybody, not for everybody, so that I love
what you're saying, but I would say that's kind of
like for one percent of the population.

Speaker 3 (43:29):
That's the issue. And by the way, one of the
world's experts on this who is ahead of all those
guys you mentioned is doctor delbry Kiproff, who is right
here in Marin County, right in Mill Valley. He and
I were both together years ago at uc San Francisco
in our training, So he's been doing this for a
long time and is very successful and has shown there's

(43:50):
some improvement in cognition as well. So these are you know,
this is another issue, so detox and then the final
one is some targeted supplements. These can help to reduce
the inflammation you were talking about earlier. And I have
met doctor Stephen Sinatra, so I know his work.

Speaker 1 (44:08):
Did you know that he passed away.

Speaker 3 (44:10):
I had no because I haven't seen him in several years.
I've interacted with his son as well. Yeah, yeah, I
met him late in his career obviously, so, but I
think you know what what he's done and his son
has done very important. We always say, well, you've got
to find out also what's causing the inflammation, because you

(44:32):
don't want to just reduce the inflammation without knowing what
it's doing. It's there for just like the amyloid, it's
there for a reason.

Speaker 2 (44:41):
Well, you didn't say the vascular part, but that certainly,
and you did say the gut, the big green gut,
access to the microbios But what about the vascular and
what about the genetics and what about the hormones. This
seems like there's so many potential causative fact but you

(45:01):
talked about those for a moment.

Speaker 1 (45:03):
Yeah.

Speaker 3 (45:04):
So when I said, remember and energetics, inflammation and toxicity, Yeah,
so the vascular is absolutely part of the energetics. So
I mentioned you have to have good blood flow, oxygenation,
mitochondrial function, and that's where ketone level turns out to
be important as well, and insulin sensitivity. Metabolic flexibility. As

(45:24):
my wife taught me many years ago, she's an outstanding
integrated physician. As she taught me many years ago, metabolic
flexibility is very important, So the ability to go seamlessly
back and forth between utilizing glucose and utilizing keytones. You know,
our brains are like a prius, they are like a hybrid.
They only come on two things. They run on glucose,

(45:46):
they run on keytones. So you have insulin resistance, you
lose both of those. A high insulin, you're not using
your glucose well and you're not able to make keytones.
Now you mentioned hormones, Optimizing your whole hormones also helps
that energetic support helps support the neuronal structure in your brain.

(46:08):
So absolutely these are important as well, so the function dale.

Speaker 2 (46:14):
Are there any specific hormones that you would list as
the most important for brain health?

Speaker 3 (46:21):
Yes, so there are several. Now, as you know, there's
a controversy about BHRT bioidentical hormone replacement therapy, but there
are repeated studies coming out showing they do improve brain health.
And you talk to an expert like doctor Ann Hathaway
or doctor Prudence Hall or doctor Felice Gersh, there are

(46:44):
numerous experts, Doctor Robert of Diaz, Brenton, all of these
people will tell you these do support brain health and
so estradol, progesterone, testosterone, pregnenolone. These are all important. Thyroid
is another important one to have optimal thyroids. So many

(47:05):
of us have low thyroid and have some degree of hushamotives.
So all of these things are helpful in optimizing our
brain health.

Speaker 1 (47:15):
And data because of the adrenas.

Speaker 3 (47:18):
That's another one that stress stress, Yes, and you know,
part of the when we look at the seven basics
and before we do the two specifics of infections and toxins,
the seven specifics do include managing stress. You know, we
were meant to be able to survive periods of brief
periods of stress with resolution. The problem is chronic, unremitting

(47:43):
stress and that is associated with brain shrinkage, associated with
cognitive decline. So we want to avoid that ongoing, which
is why again good thing. Check your heart rate variability
and you can improve. There's so many things you can
do to address stress us, everything from meditation to yoga

(48:04):
to you know, dealing with the issues in your life,
to uh, you know, to things like shinrin yoku that's
so called forest bathing, bio feedback. They're all these things
and there's no question they can be very helpful and just.

Speaker 2 (48:18):
Just walking out your front door to if you're able to,
and like we are in California most of the year
and taking a walk in nature is one of the
most incredibly mindful activities.

Speaker 1 (48:32):
Plus you're getting good exercise exactly.

Speaker 2 (48:36):
Yeah, So okay, Dale, these are there's a lot here,
as you know, and you know, I'm sure you understand
that most people who have been not have not been
open minded because their physicians haven't been open minded to
taking these steps. But you are really embracing the integrated
medicine model, which is look for the root cause, don't

(49:00):
try to just treat a symptom with a drug. So
I mean, if I could summarize what integrative medicine and
functional medicine is compared to allopathic that would be the
first one. You said physiology to I mean, from pathology
to physiologists, very similar saying for similar things. But you

(49:21):
are embracing so many aspects. So break it down a
little bit further for us is how do you determine when.

Speaker 1 (49:30):
You have a patient, which of all these.

Speaker 2 (49:34):
Issues that you've just mentioned are the cause of their
particular condition, and how do you then how do you
find how do you be a detective and find the
root cause.

Speaker 3 (49:46):
Yeah, great point. And you know, we would recommend just
take it at your own pace. If you can just
begin with a couple of things, you'll notice improvements over time.
But to get an optimal outcome, you want to just
keep on at your own pace, adding things. Working with
a brain health coach really helpful. They can help you
stay on track. So the way we figure out what's
wrong is the blood test that I mentioned. So there's

(50:09):
the first one that tells you where you stand currently,
that's brain scan. We could get a brain scan dot com.
Then there's the one that says where are you headed
and what's driving it? And that Those are so called
recode labs and you can also get those online. You
can also get them at a local drawstation. It's very easy.
And then from that we generate. We have a computer

(50:32):
based algorithm that goes through all the things. That used
to take me about two and a half hours per
patient to go through every single thing and figure out, okay,
here's an optimal plan for you. Now the computer does that,
you know, in a few microseconds, so much much faster.
So that's why we made this whole algorithm so that
you can now see what to do here and it'll

(50:55):
tell you base not only on your blood test, but
also on some of your symptoms. So, for example, people
who begin their cognitive change with depression and we hear
this all the time, and they more likely have toxicity
as one of the important contributors to their cognitive change,
whereas people who begin it with an amnestic you know,

(51:18):
with a memory issues, tend often to be more on
the metabolic and inflammatory side. That that's one of hundreds
of variables. So looking at all these different blood tests,
we put the whole thing together, the computer crunches it
and then says, Okay, here's what's most likely for you,
and that's what's gotten the best outcomes.

Speaker 1 (51:38):
So, if you were to take a.

Speaker 2 (51:43):
History of your journey of thirty years, this is thirty
years right that you've dedicated yourself. Who has been the
person that is most affected your outcome as to where
you are today?

Speaker 1 (51:58):
Who has been your.

Speaker 3 (52:02):
Well you mean in terms of teachers, Yeah.

Speaker 2 (52:04):
Teachers or PATRII individual can be anybody you know who
has influenced.

Speaker 1 (52:08):
You to be who you are today in the most
to be who you are today.

Speaker 3 (52:13):
Yeah, Well, when it comes to uh, you know, teaching
and uh, you know my role model, my my hero
is Lee Hood. He was a professor at cal Tech
when I was an undergrad at cal Tech. He was
the one thinking about the future of biology. He's the
one that developed the DNA sequencer. He's the one that
developed the peptide sequencer, uh, and developed the peptide and

(52:37):
oligo synthesizers. He's always been and I mentioned this in
the new book. He's always been a step ahead of
everybody else. And so we fashion what we're doing based
on what Lee taught taught me over the years. And
then of course he Bill Gates attracted Lee to come
up to Washington and he ultimately set up his own institute,

(52:59):
Institute for Systems Biology, and he's he's always been looking
at the future. Now he's more on the research side.
We've tried to take that research into the clinic and said, Okay,
if this research is correct, we should be able to
heal people's brains fantastically and so exciting to see. Yes,

(53:21):
we see it again and again and again. We've had
thousands now, we've treated over over ten thousand patients. So
we've got a lot of wonderful outcomes, and we still
want to understand. There are others that don't get good outcomes,
and we want to understand why did they miss something?
Did we miss something, or did they not do the

(53:42):
right things? Were there additional things that we're driving this
did we get into late? Are these are a toxin
we didn't recognize? You know, many many issues. But the
good news is, as I mentioned in our trial, the
vast majority of people do very well. And the earlier
you start, the easier it is.

Speaker 2 (53:59):
You know, I would almost guarantee you that the ones
that don't do well are not as compliant with with
the daunting task of changing their habits. Yeah, and there
are some people who just you know, I hate to
say it, but they're just lazy about I mean, they
know they have a condition, but they don't have that
motivation like the like.

Speaker 1 (54:20):
Like Judy does or did motivating you know.

Speaker 2 (54:24):
To really embrace the challenge and to rise rise to
the opportunity to you know, improve their lives.

Speaker 1 (54:33):
And so I would I would bet you that it's
more of that, like you know, just diet alone. Look
at the creatures of habit and you know, with with
nutrition and people just have trouble making those changes. And you,
by the way, I meant to ask you. You mentioned key.

Speaker 2 (54:50):
Tones, and I want to be sure our viewers understand
what a key tone is.

Speaker 1 (54:54):
Can you just take a moment.

Speaker 2 (54:56):
I know we're going to have to end soon, but
I don't want to miss that because everybody, you know,
misunderstands when you're on the Keto diet.

Speaker 1 (55:03):
They think you're eating butter and steak and day and bacon,
and that's not what.

Speaker 2 (55:09):
You're talking about. I don't want people to go away
being thinking that's what they should go to the grocery
store start buying all these very bad processed food.

Speaker 1 (55:18):
So could you just take a second to define a
key too.

Speaker 3 (55:21):
Yeah, So, as you said, the diet is plant rich,
mildly ketogenic.

Speaker 1 (55:28):
Yes.

Speaker 3 (55:29):
Have wild caught fish, yes, have some pastured chicken, yes,
have some grass fed beef. Those are all great. Yes,
have some pastured eggs great. But it's a plant rich
You want to have big, big vegetables, big salads, these sorts,
eat the rainbow sort of things, and so many things
that are helpful there.

Speaker 2 (55:47):
And you know you didn't Another thing we didn't talk
about is intermittent fasting, which I know you and I
are both doing that. I usually I usually end my
meal my last meal, around seven, and then I don't
eat again. I'll eat when we get off this podcast,
and it'll be about let's say.

Speaker 1 (56:04):
New So you know, I know you'd say twelve to
fourteen if you're a.

Speaker 2 (56:08):
Poeple will talk about the genes and real quickly in
a moment. But so, so, I think that's an important
thing for people to know that intermittent fast and produces
the autophogy, which really is a way to get your
blood sugar, your metabolic in your insulin levels under control.

(56:28):
So I wanted to be sure that that you know,
we included that is another way that you can not
only lose weight or.

Speaker 1 (56:36):
At least keep your current way stable. But anyway, go ahead,
I'm sorry.

Speaker 3 (56:41):
So you're right, So you want to become insulin sensitive.
As I mentioned earlier, you know, your brain only functions
on those two things, glucose or keytones. So keytones are
made by your liver. It's a way for your liver
to export energy to your brain. So it takes literally
biochemical energy in the form of acetyl CoA that uses

(57:05):
it to produce ketones, which then travel through your blood
up to your brain and other organs and then they
are turned back into the energy and they are burned
and burned with your mitochondria. And so it's a way
to export and utilize energy. And so when you are
when you don't have enough glucose, when you are when

(57:27):
you are low, you're not eating, for example, you're sleeping,
you will now make these things. And the problem is
if you don't have the glucose and you don't have
the keytones, then your brain is sputtering. It's like a
prius that has no electricity and no fuel just can't go.
And that's what we see with so many people who

(57:48):
have cognitive changes. It's because they cannot utilize and make
that energy. So we recommend, just at the beginning, just
take some exogynous keytones while we're getting you into this
metabolic flexibility. Yeah, people will notice when they get into it,
oh my gosh, my brain is working so much better
and I've got more energy than before. That's the key.

Speaker 1 (58:09):
And add to that list of you know, first cold
press organic olive oil, avocados, you know, things that are
healthy fats.

Speaker 2 (58:17):
Take out get rid of those seed oils which are
really maybe six is our killers to Yeah, there's so
much you know what I was thinking with gray matters,
it might be good to affiliate with some nutritional coaches
that can take people right to the grocery store and.

Speaker 4 (58:34):
Help them, you know, really physically buy the right things
instead of all being tempted by what typical grocery stores do,
which is to tempt you into buying things that are
not good for you.

Speaker 1 (58:45):
Well, I know they're going to end this.

Speaker 2 (58:47):
I mean they're going to want me to end this now,
but I want to be sure to say one last
thing about the.

Speaker 1 (58:51):
Apoe gene apo E four.

Speaker 2 (58:54):
Can you just quickly tell us what is the what
are the percentages of people that have apo E four
positive negative? Is that is the main genetics that kind
of predisposes to you to Alzheimer's.

Speaker 3 (59:07):
Yes, there are one hundred different genes, but Apoi is
the common one, and so there is So if you
have zero copies, and that's three quarters of our population,
your lifetime risk for Alzheimer's is nine percent. So I'm
an apoe three to three for example, I have an
apo E four negative. Yeah, it's not zero, by the way, Great,
good to know. Yeah, then if you have a single copy.

(59:29):
That's seventy five million Americans, most of whom don't know it.
Your lifetime risk is thirty percent, So please check it out.
Get on active prevention. If you have two copies, and
that's seven million Americans, most of whom don't know it,
your chance is about ninety percent most likely you will
develop Alzheimer's, so again, find it. Julie G who's APO

(59:53):
E four to four had symptoms back in her late forties,
is now in her sixties. She's been on a protocol
for a long time. She's doing absolutely great. There's a
wonderful website APOE four dot info where you can have
sorts of information. Most of the people on there are
on some version of our protocol and doing very well.

Speaker 1 (01:00:12):
Oh wow.

Speaker 3 (01:00:12):
That's a critical gene for all of us to find out.
And by the way, it is in those recode labs
that I mentioned earlier. You'll know your APOE status and
you can do something about it.

Speaker 1 (01:00:21):
Yeah.

Speaker 2 (01:00:21):
So the recode every for everybody that's listening and watching
the recode is your protocol.

Speaker 1 (01:00:27):
That's what you.

Speaker 2 (01:00:28):
Developed out of all of this, and that's really what
the sumptions of what we've been talking about today. The
causes of Alzheimer's and the protocol that will help to
reverse Alzheimer's. So I just want to end on that
note to say, you know, you are a pioneer and
there are very few people that would have the courage

(01:00:48):
to do what you've done, which is to embrace a
system that is basically against you.

Speaker 1 (01:00:54):
But you're a fighter. You're like a David and Goliath.
That's the metaphor. I want to just applaud all your
efforts and never give up. Right, You're you're never going
to not after thirty years, they're certainly not going to
go backward, and you know that the results are there.
So thank you so much, Dale for being with us
today and sharing all this information. We could have talked

(01:01:18):
for another hour, but I maybe we'll have you back
next year for round two.

Speaker 3 (01:01:24):
Thank you, Michelle.

Speaker 1 (01:01:25):
Okay, you take care. Bye bye bye bye Okay bye