Dr nathan bryan

In this episode of Ageless and Timeless, host Michele Hughes welcomes Dr. Nathan Bryan, one of the world’s leading experts on nitric oxide and its critical role in human health, longevity, and disease prevention.

Michele first met Dr. Bryan at a longevity conference, and since then has admired both his groundbreaking research and his generosity of spirit. She also recently featured him in her monthly editorial column for Top Doctor Magazine, where his work on nitric oxide was highlighted as one of the most important scientific advancements in modern medicine.

Dr. Bryan shares how his career began nearly 30 years ago when nitric oxide was first recognized. Since then, he has made pioneering contributions to understanding how the body produces nitric oxide, what causes deficiencies, and how restoring this essential molecule can improve conditions ranging from cardiovascular disease to dementia.

Today, as Founder, Chairman, and CEO of Bryan Therapeutics, Inc., Dr. Bryan leads multiple clinical-stage programs developing nitric oxide–based therapies for heart disease, Alzheimer’s, and diabetic ulcers. His consumer line of nitric oxide products has also become one of the most trusted on the market.


In This Episode, You’ll Learn:
●Why nitric oxide is considered the “foundation of health” and essential for cardiovascular, metabolic, and cognitive function.
●How nitric oxide production impacts blood flow, mitochondrial function, stem cell mobilization, and telomere health.
●The reasons common supplements like L-arginine and L-citrulline often fail to restore nitric oxide.
●How lifestyle habits such as nasal breathing, oral hygiene, and diet affect nitric oxide production.
●Why nitric oxide may hold the key to treating conditions like Alzheimer’s, diabetes, hypertension, and erectile dysfunction

Dr. Bryan’s passion for science and commitment to developing both safe consumer products and FDA-approved therapies is transforming how we think about health and longevity.
Learn more about Dr. Bryan’s work:
●N1O1.com
●DrNathanSBryan.com
●BryanTherapeutics.com

Follow Dr. Bryan on Instagram @drnathansbryan and Twitter @drnitric.

✨Don’t miss Michele’s article featuring Dr. Bryan in Top Doctor Magazine

Medical Disclaimer –Ageless and Timeless PodcastAgeless and Timeless (the “Show”), along with its host and guests, shares insights and discussions on health, wellness, and longevity for informational and educational purposes only. The Show does not provide medical advice, diagnoses, treatments, cures, or preventative recommendations for any disease or health condition. The content shared should not be used as a substitute for professional medical advice, diagnosis, or treatment.While we strive to feature reputable sources and knowledgeable guests, neither Ageless and Timeless nor its host or affiliates assume responsibility for errors, omissions, or misinterpretations in the information provided. Listeners are encouraged to use their own discretion and consult with a licensed medical professional before making any health-related decisions. By listening to this podcast, you acknowledge that any actions you take based on the information presented are at your own risk, and Ageless and Timeless, its host, guests, and affiliates are not liable for any direct, indirect, incidental, or consequential damages resulting from the use of this content

Episode Transcript

Speaker 1 (00:08):
Good morning everyone.

Speaker 2 (00:09):
This is Michelle Hughes from Ageless and Timeless. I have
a guest today that I've been talking to for over
a year now, and I have to tell you a
little backstory about doctor Nathan Bryan because he's such a
special man and this will indicate what I'm more validate
what I'm talking about.

Speaker 1 (00:30):
So I was at the Radfest festival.

Speaker 2 (00:32):
And Anaheim about a year or so ago, and I
walked over to the booth called N one oh one
and Nitric outside. If anyone has heard of the Nightrik Outside,
you know that that's a big hot topic these days.
So I was really interested because of my podcast to
meet doctor Brian.

Speaker 1 (00:52):
And anyway, it turned out by just good fortune.

Speaker 2 (00:56):
Susan, his partner, was there and then doctor Brian came
by and so we started chatting, and I mean, I
was just so engaged in all that he's done. So
today we're going to hear his backstory on how he
got to where he is today, and we're going to

(01:16):
hear all about deep dive into nitrigauxide. But the story
I was going to tell you is that so I
needed a ride to Los Angeles and I happened to
mention to doctor Brian that I was going up to
LA after the and right away he offered me a
ride with flying back to the air or going back
to the airport to fly back to home.

Speaker 1 (01:38):
So I was just so impressive.

Speaker 2 (01:39):
Here was a complete stranger and here he was so
generous to offer. That turned out my schedule change and
we didn't do it, And I actually regret that because
I think I would have learned an awful lot in
that one hour, just having him one on one that
outside of a conference. But anyway, it just shows you
the generosity of Brian. And actually I like him so

(02:02):
much that I have him in October, well September, but
it won't come out until October.

Speaker 1 (02:08):
First. He'll be the feature column in.

Speaker 2 (02:11):
My Top Doctor magazine, so I do a monthly column there.
So if you are listening to this podcast or watching
it today, please check out Topdoctor dot com and you'll
see another piece on doctor Brian.

Speaker 1 (02:26):
So, good morning, Nathan. How are you well great?

Speaker 3 (02:29):
It's great to see you. I'm doing fantastic.

Speaker 1 (02:32):
How were you I'm doing great. Are you in Austin today?

Speaker 4 (02:36):
I am.

Speaker 3 (02:37):
I'm home for the next couple of days. I live
about an hour outside of Austin. But I just flew
in from Miami yesterday and headed to New York next week.

Speaker 1 (02:44):
Yeah, you're on an airplane a lot.

Speaker 2 (02:47):
So Nathan, you know, Night to Go Outside has become
one of the darlings of the longevity movement, and a
lot of people, however, I'm shocked, haven't really understood or
even know about it. So why don't we start first
with how did you get so engaged in an area
that is still emerging and evolving as a longevity I

(03:12):
don't even want to say a biohap because it really
is a scientific breakthrough that people haven't really understood.

Speaker 1 (03:19):
So it's kind of like inflammation was for many years.

Speaker 2 (03:23):
If you remember when they first started talking about inflammation,
everybody compooted in the medical world, and then suddenly it
became this, you know, very important part of the three
leged stool of health. Right, So I think Nikagatxa might
be the fourth leg. So let's start in the beginning.
So what is it that brought you to this awareness

(03:45):
of something that's so important and so young at such
a young age.

Speaker 3 (03:49):
Well that takes me back almost thirty years, I know,
and you're not that old.

Speaker 1 (03:55):
So Okay, so thirty years.

Speaker 3 (03:58):
Means early nineteen Yeah, the late nineties, yeah, late nineties.

Speaker 1 (04:02):
Early ties. I'm sorry.

Speaker 3 (04:05):
Yeah. So I was a student at LSU School of Medicine.
I was working on a PhD in molecular study of physiology,
and a Nobel Prize had just been awarded for discovery
of nitric oxide. And honestly, you know, I had a
degree in biol chemistry from the University of Texas at Austin,
so I was familiar with nitrogen based chemistry. Is obviously
nitrocoxide part of the gentrification unification cycle, but it was
a new molecule in science or medicine. But obviously it

(04:27):
was important because the Nobel Prize had just been awarded
for the discovery of nitric oxide as a signaling molecule
in the cardiovascer system. And during my PhD work, I
was working under a pharmacologist who became my mentor, Martin Feelish,
who had worked in the nitrocoxide field for you know,
since the early eighties and when it was just first
starting to be discovered, and so had I had a

(04:48):
chance to meet lou Ignaro, who had just won the
Nobel Prize, and you know piqued my interest. It was
an exciting time. And you know, nitrocoxide's this gas that's
one it's produced, it's gone in less than a second.
So we didn't have a lot of analytical tools to
measure nitrocoxide production in animals in humans. So part of
my PhD was developing these analytical methods where it could

(05:08):
detect nitrocoxide and when nitrocoxide is produced, where does it
go and what does it become? And how does it signal?
Because once it's produced, it's gone in less than a second,
So you know, we started trying to figure this out
through these nitrocoxide analytical methods that we developed, and we
understood the metabolism of nitrocoxide, how it's produced, when it's produced,

(05:29):
where does it go, what is it becoming, how does
it signal? And then how do we detect nitrocoxide deficiencies
in many different diseases from diabetes to hard disease to
transplantation surgery. So then we were armed. Our group was
armed with really a lot of tools that no one
else in the world had. I finished my PhD in
less than two years. I think I published two or
three first author papers during that time, and then went

(05:51):
to Boston Medical Center and was training in the cardiovascu
as a a postdoctoral fellow. And then Fredmiradded, the other
guy who won the Nobel Rise, recruited me to join
faculty of ut Medical School in Houston. And I believe
it was two thousand and five, so twenty years ago
where I started my own independent research career and you know,
again continued our journey of discovery and innovations and you know,

(06:13):
started filing patents, patents became issued, and then started making
products and starting companies and well, you.

Speaker 2 (06:19):
Know later, you know, I did watch Blue on.

Speaker 1 (06:26):
On a tiv on an internet show.

Speaker 2 (06:28):
I don't know if there's a podcast, But anyway, is
he still with you today?

Speaker 1 (06:32):
I mean, do you collaborate with him?

Speaker 4 (06:35):
Now?

Speaker 3 (06:35):
Low is a close friend and colleague, and he's you know,
the only remaining surviving member of the Nobel Nobel Aureates.
But yeah, no, Look, I'm hosting the Nitric Oxide Society
meeting in Austin in April of next year and lose
our keynote, lose part of the organizing committee. So you know,
he's still active. You know, he's still very active in

(06:55):
the nitric oxide community. He's such a wonderful, caring, humble
man and really supportive his new investigators and just he
has been achieving.

Speaker 2 (07:05):
I was just about to say to you he was
so humble that he didn't even when he was asked
about his background, he didn't even mention the Nobel Prize,
and the interviewer had to say, well, you're you're omitting
one very very important piece of information. So yeah, he
had to pull it out of him. I mean, that's
that just shows you his humility. So what has happened

(07:26):
from then to now in terms of your the scientific
awareness of the importance of nitrogoxide.

Speaker 1 (07:34):
That's you know, it's thirty years. So what what has transpired?

Speaker 3 (07:38):
Well, today we understand how the human body makes nitrocoxide,
we understand what leads to a loss of its production,
We understand the symptoms that develop as a loss of
nitrocoux as a result of the loss of microcoxid production,
and most importantly, we know how to overcome and fix
and repair and recapitulate nitrocoxide production and signaling. So, you know,

(07:58):
I like to say, those guys has discovered that nitrocoxide
is a signaling molecule in the cardiovascar system. But it
was really the work of me and my research group.
We discovered how to deliver nitrocoxide gas. So we make
a solid dose form of nitrocoxide gas. We can deliver
this in an outpatient setting. We do this through consumer
products and supplements and nutritionals and skincare products. We're developing

(08:20):
drug therapy, which was my original kind of goal when
I started in academia and medicine was to understand the
mechanism disease to the extent that you could start to
develop rational therapies. And that's what we're doing. We've got
drugs in development for heart disease, got drugs in development
for Alzheimer's and dementia. Make a topical drug for diabetic
ulcers and non healing wounds. And that's just the start,

(08:40):
you know, because now what we know, it's not what
we think. It's what we know that there's not a
single condition or disease indication where nitrocoxide at the right
dose at the right time and the right patient would
not be beneficial. And so the future of medicine, health wellness,
human optimization is absolutely dependent upon adequate production of mitrocoxae,

(09:02):
and we know how to do it better than anybody
in the world. And that's what we're doing. When you
say we, what do you mean we mean collectively? You know,
I never say I know many of the patents. I'm
on the sole in vendor on these patents, but you know,
it's a team I had, you know, when I was
in academia, had you know, research fellows, I had postdocs,
I had faculty and staff that work with me in collaboration.

(09:25):
So I never take credit for this solely. And then
when I say we, now, you know, I have several
companies and executives within the companies, there's collaborators, there's you know,
clinical trial sites that run our clinical trials. So I
never say I because it's just not part of my fabric.

Speaker 5 (09:42):
That's also showing your humility. Well, so, Nathan, why is
it that it took so long for this to become
something that people are now much more aware of? What
do you think has been the reason that has been
slowed down even with a Nobel prize back in the
late nineties.

Speaker 3 (10:02):
Well, I think there's several reason. Number One, on average,
it takes about seventeen years for new discoveries to become
so called standard of care or mainstream correct. Nitrocoxide is
only about a fifty year old. Molecule was first described
in nineteen seventy seven fred Mirad's paper showing that organic
nitrates like nitroc listenm and metabolized into nitrocoxide and then

(10:22):
that leads to vasodilation. That's how these drugs work for angeline.
And then in nineteen eighty it was discovered by Bob
Firtscott that the cells along our bud vessels produce this
nitrocoxide molecule. So that was the initial lag. It just
takes time. It has to stand the test of time
and for these experiments to be reproducible by other groups.

(10:43):
And then the other big I think lag and acceptance
is there's been no major developments or innovations in nitrocoxide
drug therapy. When I started in the field in the
late nineties, every big pharmaceutical company and biotech company had
a nitrocoxide pipeline of drugs. The reason they failed was
they were using the wrong target, they were using the
wrong strategy, and they were putting nitrocoxide linker molecules or

(11:07):
nitrocoxide active drugs on parent molecules like COX two inhibitors
or aspirin or insets, and you know you have to
you have to cleave that nitroester bond, and there's consequences
to that. So these weren't These drugs weren't safe. And
then you know, in the nineteen eighties, late eighties, early nineties,
it was starting to develop nitrocoxide therapy for innoltive therapy

(11:27):
for premature babies born with pullman or hypertension. So now
clinically that's been used for more than you know, thirty
or forty years and save millions of babies' lives that
are born premature. But then that's where the clinical innovation
really stopped. Because nitrocoxide is a gas. How do we
create a solid dose form of nitrocoxide that we can
deliver in an outpatient setting. That's really the riddle that

(11:49):
I saw, because my patents are on the method of
making a solid dose form of nitrocoxide gas. So we
make we deliver nitricoxide either topically through our orals or
through an organ disintegrating tablet or other technology. And the
whole basis of what I do is if your body
can't make nitrocoxide, then we got to give it for you. Right,
it's a hormone. It's like estrogen and testosterone. So if

(12:10):
men or women can't make testosterone or estrogen perspectively, we
give them testosterone. We give them the actual molecule. And
so what we do is we give nitrocoxide gas. Where
all of the companies out there can't do this, they
don't do it and so their products don't work.

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Speaker 3 (13:12):
Because we're never deficient in argentine or cicillin, and we're
not deficient in a dead beat powder. So taking these
products is not going to help in nitrocoxide production.

Speaker 1 (13:21):
I think that's very important what you just said, because
a lot of.

Speaker 2 (13:24):
People I know take L rgenine and they forget to
take the L siculine with it. But even what you're
just saying is if you're taking both of those, you know,
doing it the combo, it's still not going to produce
the nitrogoxide.

Speaker 1 (13:38):
That you can be used.

Speaker 3 (13:39):
Well, that's because they don't understand the biochemistry, and that's
why companies are really doing their customers of disservice and
they're killing an industry. They're killing the nitrocoxide field because
don't work and then the consumer or the patient goes
Nitrocoxide must not be that important because these products didn't
help me. But look, the enzyme that converts argentines to
nitrol coxide is broken. And furthermore, el citylene is a

(14:04):
byproduct of nitrocoxide production. It is not a precursor. Right,
So for me, it's it's an easy litmus test. If
you're looking for products in your supplement store and that
product has il argentine or el CityLine in it. Then
just dismiss it because these the people who are selling
you that product do not understand the basic biochemistry the
enzymology of how nitrocoxide is produced. So that's an easy

(14:25):
litmus test. So save your money, put the product back
on the shelf.

Speaker 2 (14:29):
And then what sorry the interpret what about it if
you added glute tocione, if you get a transderal glute
to scion, because I know glue tocion is very difficult
to absorb otherwise, uh maybe through ivs, but it's only
a short lived. So let's just say you're doing a
you know, an absorbable glutathion, which is a very rare
thing to find. Does that help the old argentine and

(14:52):
L siculine and with glutathione added to produce more of
a nitrogoxide result?

Speaker 3 (15:00):
Not necessarily? Now, not necessarily because here's the problem. The
nitrocoxide synthase enzyme is what we call a homeo dimer,
So it's two twins that come together. Okay, these these
these enzymes have to undergo a conformational change to transfer
the electrons from rgenine to make nitrocoxide, and then it spits
out citrilline as a byproduct greate limiting step in the
uncoupling of that enzyme oxidation of tetrahydroboptria. So more glue

(15:25):
de thione, more antioxidant antioxidant capacity, But just by increasing
glue to thion doesn't prevent oxidation of tetrahydroboptrin. There's a
different redox potential for glue de thione than a scorbic acid,
than alphalopoic acid, than tetrahydroboptrin, to all other antioxidants, whether
fat soluble, water soluble, enzymatic antioxidants, there's a redox potential

(15:50):
that's required to prevent the extraction of electron from all
those molecules. So the simple answer is maybe, but not
necessarily right.

Speaker 2 (15:59):
So basically what you're saying, Nathan, is if you have
an l arginine and even if you've added the l
ciculine and you're doing that combo, forget about it.

Speaker 1 (16:08):
It's not going to do. It's not going to do
what they're the manufacturers are.

Speaker 3 (16:14):
Look look, because there's very defined biochemistry. Right, there's what
we call the Michalis constant. And this may get too
technical for young but I think it's very important concept.
There's a certain concentration of a molecule that's required to
theoretically saturate fifty percent of the binding sites to activate
that somatic reaction. The Machaus concept rail argentine is five micromolar.

(16:36):
Even the sickest of sickest people, we've got one hundred
to two hundred micromolar. What does that mean? We have
twenty to forty times excess l argen. Then what's needed
to bind to the enzyme to make nitrocoxet. We're never
deficient in largen. It's a semi essential amino acid. We
get it from the breakdown of protein, whether it's animal
or plant protein, and we make it through the U recycle.
The partially recycle is present in every cell in the

(16:59):
human body, and we're easily making margining. We're constantly making situation.
We're never deficient in these inzie and these amino acids,
So it makes no sense to supplement. Why supplement something
that you're not deficient.

Speaker 1 (17:11):
That you already have.

Speaker 2 (17:14):
So Nathan, go back for a moment and just give
everybody a very good, short and easy to understand definition
beyond it being a molecular gas. But take us a
little bit deeper to what is nitricoxide.

Speaker 3 (17:33):
Well, it's a signaling molecular It's first discovered to be
a vasodilator. So when it's produced in the lining and
the blood vessel, that relaxes the smooth muscle around the
blood vessels and it leads to vasodilation. So now we
were getting increased oxygen nutrient delivery to downstream blood vessels.
It's the signal that tells our own stem cells to mobilize.
So if you have adequate nitrocoxide, you have more stem

(17:55):
cells in circulation on you know, autologous our own stem cells.
It activates an enzyme in our nucleus called telomerase, which
prevents our telomeres from shortening, so shorter telomere, shorter life span,
longer telomere's line, longer life span. And then the other
important thing about longevity is it induces mitochondria biogenesis and
it improves the efficiency of oxygen utilization to make sailor

(18:18):
energy or ATP. So if you think about that, if
you don't if you can't make nitroc oxide, you lose
the regulation of blood flowing, develop eed high blood pressure.
Insulin resistance, you have mitochondrial dysfunction, you have shorter telomeres,
and you don't repair and replace dysfunctional cells because you
don't have any stem cells in circulation. Do you want to?
You want to? You want to lead to human optimization

(18:40):
and biohacking and longer, healthier life free of disease. I
mean you have to start at nitrocoxide. That is the foundation.
There are other things you have to address, but without
added oxide production, nothing else is going to optimize you.

Speaker 1 (18:53):
And this is so compelling.

Speaker 2 (18:54):
And then that means that you know, adding all the
other you know, the five legged stool of you know
of a diet and I mean nutrition and sleep and
stress and all the things that go into a go
into a healthy lifestyle that you actually without nitrogoxide, all
of those things are not going to be nearly as effective. Right.

(19:17):
You need the nitrogoxa kind of like the foundation, like
building a house.

Speaker 1 (19:21):
That's your foundation.

Speaker 3 (19:23):
And yes, nitrocoxide is not going to replace sleep, It's
not going to replace you know, a good diet. I
mean it's a two way street. If you have addiput
nitrocoxide production, you have good rest. You can improve microoxide
production improves them sol mobilization. So you're gonna rest and repair,
right if you need it. More diet, You're gonna high sugar,
carbohydrates and you know all that. It's it's going to

(19:45):
continue to deplete, deplete your body availability to make nitrocoxide.
Taking oxide products isn't going to help you. I mean
it will help you, but it's not gonna You still
have to change your diet and do the things that
you know lead to better natural production nitrocoxide.

Speaker 2 (20:00):
Right, So this is a collaboration, but it is something
that is important to look at.

Speaker 1 (20:04):
So how do you get a baseline?

Speaker 2 (20:06):
How do you know what your nitrogoxide level is if
you're starting out on a nitric oxide journey.

Speaker 3 (20:13):
Well, you know, unfortunately there's no biomarkers like blood labs
and we can draw and give you a number of
your nitrocoxide because again, once it's produced, it's metabolized in
different metabolites. We've done this for you know, twenty five
thirty years in the research lab, but unfortunately it's not
done clinically. So what we do is we rely on symptoms.
So the first sign and symptom to develop if your

(20:33):
body becomes compromising stabilities to use. Nyitrocoxide is a rectile dysfunction.
And this is just in mail. It's a female and
if you think about it, to get an erection, either
a penile or clinical label erection, we have to increase
blood flood flood, not ngorgement, So you have to dilate
the blood vessels. Nitrocoxide dilates the blood vessels. If you
can't make nitrocoxide, we don't get vasodilation, we don't get engorgement.

(20:56):
And that is a rectile dysfunction. It's called the canary
and the coal mine, but because it it is the
canary in the coal mine, because if you have in
the field of dysfunction in the vascular bed of your
sex organs, that same dysfunctions occurring in your heart, in
your brain, in your lungs, in your liver. It's a
systemic disease that manifests first when we're trying to dilate
the blood vessels on demand. And then number two, your

(21:18):
blood pressure starts to go up because without adequate nitrocoxide,
now we've got the same volume of blood going through
smaller blood vessels and pressure does out. Number three you
start to get insulin resistance in metabolic disease. Nine out
of ten Americans are metabolically unhealthy. Number four, you can't
maintain an exercise regimen because if you can't dilate the
blood vessels to the heart or the skelele to muscle

(21:40):
when you're exercising, you tire, You get lactic acid build up,
and you can no longer maintain that exercise regional. And
then number five, you start to get brain foged, mold,
cognitive impairment, dementia, and eventually Alzheimer's. So those are the
things that you should pay attention on. And you know,
the analogy I use is that you're, you know, our smartphone.

(22:00):
When we look at our smartphone and we see the
red light come on here that our batteries low, people
pay and they go, oh shit, I got to charge
my battery. Ed is your red light coming on? Senior batteries?
High blood pressure, insular resistance, exercise intolerance, cognitive brain full
that's your body telling you, hey, I need some nitrococide.
I'm getting low, and so pay attention. Your body's always

(22:22):
talking to you. He's going to pay attention.

Speaker 2 (22:25):
But yet, Nathan, if you're going to a even a
functional medicine doctor, how often if they have these symptoms,
are they going to tell someone to go get nitrogoxide?
You know, talk to me doctor Brian and go to
N one oh one your company and you know, start
using the product. So you know in your experience, are

(22:45):
people that are in your world, in your wheelhouse are
they are they advocating that as a solution for those
kinds of symptoms.

Speaker 3 (22:55):
You know, we're making some progress, but here's the problem.
I mean, as this market is expanding and the awareness
around nitrocoxide is growing, more companies are coming in trying
to sell a nitrocoxide product. Yes, doctors will recommend it
because they've got sales people in there. They hear a
webinar or here's something they go, well, let me try
this nitrocoxide pid or I saw a commercial on TV.

(23:17):
And then they say, well to take this be product
and then come back. Whether patient comes back and they go, well,
this didn't help me, and then we lose. We lose
the conversation. And it's not nitrocoxide didn't work for that patient.
It's because that product cannot, did not and will not
ever produce nitrocoxide in that patient because that product doesn't
address the root cause of their deficiency, because they're either ignorant,

(23:39):
and ignorance is fine, it's just a lack of knowledge,
or they're deceptive and fraudulent, which any companies out there
who are intentionally defrauding their customers because it's a it's
a cheaper product that they can sell for higher profits
and it cannot and will not produce nitrocoxide. And I
think that's why these conversations are so important, because all products,
not just notox have can be based on science and

(24:02):
it has to be personalized. And that's why I like
the functional integrative docs because they have time to spend
with their patients to get an insight into their lifestyle,
their diet, what are their deficiencies, what are their talks
and exposures, and then develop personalized therapies for them. Well,
if you go to standard allopathic doc, you get five
minutes with you and which is oh, you got ed.

(24:23):
Here's a sildenti fil.

Speaker 1 (24:24):
Or vitrop look at, give me some viagra, an.

Speaker 3 (24:30):
Acid hypn or arb for your hypertension. Here's some met
foreman for your diabetes. And here's the ambient because you
can't sleep, and then you wake up and you're on
a dozen different medications, and people wonder where they're sick. Right.

Speaker 1 (24:42):
So you mentioned though that you're developing drugs.

Speaker 2 (24:45):
Now, so how did you cross that bridge to get
to the allopathic community and get them to agree to
work with you on on nitrogogxide in other words, including
nitrogoxat in in an pharmaceutical side of the medical world.

Speaker 3 (25:03):
Well, I can tell you it was never my intent
going into academia to be a developer of dietary supplements.
That was never even online radar, right. But because we
had developed a way to produce nitrocoxide, and because I
knew how to do this through natural products and through
food and through modification of the microbiome and affecting the
structure and function of the enzyme, we could do this

(25:24):
through natural products and through dietary supplements. But the goal
all along was to develop drug therapy how to deliver
nitro patient setting. So we're not convincing the allopathic community
to work with us because they can't because we don't
have an FDA drug approved on the market. So what
we do is we go to the FDA we have
meetings with the FDA. So look, here's what we want

(25:45):
to do. We want to go after schemic car disease.
Here's our nitric oxide releasing drug that when we take this,
we dilate the blood vessels, we relieve the schemic pain
known as ANGEL and we can prolong exercise induced agen
And by the way, it works better than isosorb by
diet nitrade or nitroglycery, and it's safer, so we can
miss the FDA. We're gonna design a clinical trial. We're
gonna test this in a double blind fall seabook controlled study,

(26:08):
and if we hit our endpoints, the FDA agreed that
they'll approved this drug, and then we've got a new
drug indication for a scheme of card disease. We did
the same thing with Alzheimer's. You go all the FDA go. Look,
Alzheimer's is a metabolic master of disease. We're developing a
nitrocoxet releasing drug that improves glucose ub take that improve
the profusion of the brain, overcomes focal a schemia, we

(26:29):
don't get misfolding of proteins, and it addresses the root
cause of dementia. Alzheimer's. So we're gonna design a clinical trial.
We're gonna test it in a placebo controlled randomized clinical trial,
and if we hit these endpoints, well, can we agree
to approve this drug based on the design of this study.
It's we have to go to the FDA, we have
to design clinical studies, we have to do the clinical studies,

(26:52):
and these are tens of millions of dollars and take many.

Speaker 1 (26:55):
Many years. I was just about to saying this is very.

Speaker 3 (26:59):
Cost It's very costly, you know. And I've intentionally avoided
private equity money of venture capital money because I don't
want these people interfering with the science, because they're more
interested in making money than advancing the science. And exactly utually,
for me, I'm not doing this for the money. I've
made enough money in my career to live happily ever
after so I can be bought and I will not

(27:21):
be bought. But it's taken me a little bit longer
because I have to self fund these studies and go
out and raise money from people, individuals who know what
we're doing, who understand what we're doing, who understand the
global impact if we're successful, not if we're successful when
we're successful, how this is going to change the world.
And we're not doing it for the money. We're doing

(27:42):
it to do the right thing.

Speaker 2 (27:44):
So I want to ask you, because we talked about
the baseline, how do you measure and you said, okay,
you look at the symptoms. I wanted a more quantitative
measurement when we first met each other, so I asked
cal Roy ed Hoy is a good friend of.

Speaker 1 (28:00):
Mine, and uh, you know, you know who.

Speaker 2 (28:02):
They are, and I assume that they're doing the glycocalyx
and the they have a they have a nitric oxide product,
and I.

Speaker 3 (28:11):
Asked them, they don't have a nitrocoxide product. They get
potassium nitrate in a capsule. Nitride is not nitrocoxide. Okay,
that's the record that I want to always keep.

Speaker 1 (28:21):
String Okay, sorry about that.

Speaker 3 (28:23):
We can electrocoxide product, but it's not a product.

Speaker 2 (28:30):
But however, they used the strips and I just had
one right here, which I did right this morning, uh before,
but I did it after I ate and I realized
you slosed to do these on an empty stomach, and
I so I probably I didn't do it right.

Speaker 1 (28:43):
But this is the one that Ed sent me and you.

Speaker 2 (28:47):
Said you developed those strips twenty five years ago and
that you don't really use them as a measurement.

Speaker 1 (28:54):
So why is that? And and you know.

Speaker 2 (28:57):
If you wanted just a quick like, okay, how am
I doing? And you know, yeah, I don't have any
symptoms that you just described. I'm perfectly uh, you know,
seemed perfectly fine. But I want to know, you know,
is this product that I take, which I take your
lodgingery every day, is this making a difference? And you know,
and you know, we are a kind of a quantitative

(29:20):
for sure. We always like to compete with each other
and know what where what our score is, right, So this.

Speaker 1 (29:26):
Is one of the ways you do that. So so
what else what can we do? If you don't, I'll
tell you.

Speaker 3 (29:32):
I'll tell you the story, the backstory with those test strips.
So when I launched my very first product technology, no
one knew what nitrocoxide was. And the number one question
we had, and we did market uh focus groups in
market research, was how do I know if I need it?
So the only way to do this, I mean, we
could draw blood and that's what we did in the
research lab. And I've published over one hundred peeroview papers

(29:53):
on mapping out these nitrocoxxide metaboloids. But I thought, well,
I can develop a salary test strip. So in two
thousand and nine, I developed the first and only non
invasive point of care diagnostic for nitrocoxide. And it's that
exact same chemistry that's on that test strip. Factorum, we
launched them, I filed patents on it, and several years

(30:13):
into By the way, it's very old chemistry. It's called
the grease reaction. It's probably over one hundred year old
known chemical reaction. The chances of getting a patent on
that chemistry was very low. So probably in twenty twelve
twenty thirteen, when the bills were starting to come into
the University of Texas on prosecuting that patent, and because

(30:35):
we weren't making money on it, the university wasn't making
money on it, agreed, Okay, let's abandon the patent because
it's a tool, right you can. If you know what
you're measuring, it's a useful tool. If you don't know
what you're measuring, it's a deceptive tool. So number one,
it is not a nitric oxide test trip. Now there's

(30:56):
at least three or four companies out there selling my
original salbrate test strips because I banon the patent and
they certainly can do it, but they're still using it,
and so what they're measuring, it's not measuring nitrocoxide. The
chemistry is called the grease reaction. You put acidified sulfonillamite
on that test strip, it reacts with nitrite in the
saliva and it forms a diazo compound. It turns pink

(31:19):
the five hundred and forty enemes, So if it turns pink,
it tells us that your saliva's enriched did nitrite. It's
nothing to do with nitrocoxide. But if you understand the
metabolism sentaro salbrat circuit, that what it's really measuring is
do you have the right oral bacteria and if you're
getting enough nitrate from your diet, are the bacteria in

(31:41):
your mouth on your tongue converting that nitrate into nitrite.
That's what we're detecting. But it's also detecting the immune
response to an oral infection. So if you have an
active oral infection, if you've got infected root canals, if
you've got cavitations, if you've got oral dyspiosis and there's
an immune rey action occurring, our immune cells, macrophages, neutrophils,

(32:03):
and monocytes produced nitric oxide so oxidized to tride in
your saliva and you're picking up a local immune response.
So the one of the reasons I abandoned that is
because we would see people come in with high blood pressure,
ten years of rectile dysfunction, they were diabetic, they were obese,
they had a fatty fatty liver disease, and was say, here,

(32:24):
use this test trip and they would light it up
like a Christmas tree. You could see I make plenty
nitric oxide and they go, no, we send him to
a Dennis. We do a three DCT cone. He's eat
up with oral infections. Right, and now we know that
most people are walking around with asymptomatic infections and it's
a it's a false positive, and it's a very dangerous

(32:45):
false positive. So that's why I tell people, if you
understand what that's measuring, and now you can interrogate it.
If you're low, they're not a false negatives. And that's
really if there's any utility to it, if you spit
on it and it's low. You're low, you're nitric oxide
deficient because you have any field dysfunction. Is it because
you don't have the right oral bacteria. Is it because
you're not getting enough nitrate from your diet. Is it

(33:06):
because you take in acids or your stomach's not making
stomach acid? Is it because you have a you know,
silent receptor transported blockage in the in the salavary glands,
because you have chogrin syndrome. I mean, there's a laundry
list of things that could explain why you're nitric oxide defission.
But then if you don't understand that, how do you
fix it? Then telling you you're low, but don't understand

(33:29):
the physiology about chemistry of why you're testing low, and
they want to get they think they can fix your
problem based on that test trip. I mean, it would
be humorous if it wasn't dangerous.

Speaker 2 (33:40):
That's pretty amazing that you could get a bright pink result,
think you're ok, you're great, and yet it's really an
oral infection that's causing you to get this bright pink result.

Speaker 3 (33:52):
You know, and then people just going about their business,
they never go see a biological dentist to look deeper.
Than an X ray into a CT and realize they
have an asymptomatic osteomocrotic infection going on. That's going to
cause enormous problems fibromyalgia, autoimmune disease, cancers. I mean, it's
bad news.

Speaker 2 (34:10):
So let's start from the top. Okay, starting at the head,
because I'm going to go from the head to the toe. Okay,
so let's I'm probably starting with the biggest one of all,
which is Alzheimer's because it's the brain.

Speaker 1 (34:22):
But why don't you start there and say, you know,
explain how the influence of.

Speaker 2 (34:27):
Low nitric oxide can affect the result in the production
of of of beta amyloid or let's just say Alzheimer's
or dimension.

Speaker 3 (34:39):
Well, there's a progression of this, right, it's called mod
cognitive impairment, called Bastard dementia, Alzheimer's disease exactly just like
any any disease, there's a progression. And so if you
catch this early on, what do we call it brain
fog or MCI mon cognitive impairment. If you look at
cerebral blood flow, and you can do this through a
functional MRI, you can do it through spec scans, which

(35:03):
I like spec scins and doctor Daniel Laman's word, because
it really tells us what parts of the brain are
perfused in which are not, and so in these mild
cognitive impairments, really any neurological disease, there's what's called focal
a schemium. So if you look at a spec scan
and dementia or Alzheimer's, the prefone of cortex and parts
of the brain are don't show up on the spec scin,

(35:24):
and that's because that part of the brain is not
getting perfused. So it's called vascular dementia. Why because there's
a vaster component to the dementia. There's loss of regulation
of blood flow. Just like if you lose the regulation
of blood flow to the sex organs, they fail. If
you lose regulation of blood flow of the brain, it
fails and symptoms manifest depending upon which readiers of the

(35:45):
brain develop a schemi or hypoxia. And then number two,
and you've heard this called Alzheimer's, we called diabetes type three.
It's insulin resistance in the brain. So number one, if
you're not getting oxygen and nutrients to the parts of
the brain and you can't get glucose into the cell
for that cell to make ATP or cell your energy.
If that's cell to do its job, you get misfolding

(36:07):
a protein. And then what is that misfolded protein. We
call that tau tangle. We call it amyloid plaque. That's
what shows up in the later stages. So how you
fix it. You perfuse the brain, You give nitrocoxide, you
dilate the blood vessels. In twenty eleven, my research group
was the first group in the history of nitrocoxide to
show that nitrocoxide is required for insulin signaling. For insulin

(36:31):
to do its job, it binds to the instant receptor,
starts an intrasidar signaling cascade, activates nitrocoxide production. Nitrocoxide activates
glute forourd glute four goes to the membrane brings glucose in.
Without nitrocoxide production, glute four never gets the signal. You
develop insular resistance. So instant resistance is a symptom of
nitrocoxide deficiency. So when we give nitrocoxide to dementia patients,

(36:53):
we dilate the bloodvessils, We perfuse the brain. We show
the improvement on spec skins and NMRI, and we improve
glucose ubtake into the cell. So if we're delivering oxygen,
delivering nutrients, activating mitochondric getting glucose into the cell, so
the mitochondric can make sailor energy and atp the proteins
do their job, the enzymes do their job. You don't

(37:14):
get misfolding of proteins. There's no tall tangle, there's no
amyloid plaque, and there's no loss of cognition. That's why
nitric oxide will be the end the cure to Alzheimer's,
and that's why all drugs against Alzheimer's have failed, because
amyloid plaque and tall tangles do not cause disease. They're
the consequence of disease. And developing drug targets towards the

(37:35):
consequence of any disease is a sure failure. And it's
unfortunate that companies just spent billions and billions of dollars
of taxpayer money on target.

Speaker 1 (37:46):
I know doctor Gale Brettison, who is the father of.

Speaker 2 (37:53):
The natural cures to Alzheimer's, which was on my podcast,
and he said that same thing.

Speaker 1 (38:01):
You know that they're just missing what is it forty billion.

Speaker 2 (38:04):
Dollars or something like that has been spent on Alzheimer's
drugs with no success.

Speaker 1 (38:10):
That that's like shameful and.

Speaker 3 (38:14):
Sorry, it's very predictable.

Speaker 1 (38:16):
Yeah, why why have they ignored NITROGOTSA.

Speaker 2 (38:20):
I mean, if they would be so easy to with
the current drugs to now incorporate the knowledge that you're
providing and the world you know of medicine is providing
with nitrogotxa, why haven't they recognized that and done something
about it?

Speaker 3 (38:37):
Well, Number one, these companies are for profit companies, right,
and I have a number of patents on ways that
we deliver nitrocoxide. Look, there's many ways to skin a cat.
They can, there's other technologies out there. But in big business,
there is no money in cures, right, the money and
the trillion dollar big form of business is dependent upon
monthly recurring revenue, getting people on drug and keeping them

(39:00):
on drugs for the rest of em No matter what
business you're in, a for profit business has two goals.
Get as many customers as you can and retain the
customer for as long as you can. Yeah, that's that's
the big I.

Speaker 2 (39:11):
Mean, the drug companies have the best business model that
exists in the world because they can't.

Speaker 1 (39:18):
They basically capture you.

Speaker 2 (39:20):
You know, you take one drug to help another drug
that helps another drug, and you know, so basically, yeah,
I mean it's crazy because they you're basically addicted to
using pharmaceutical drugs and it's a it's a downward spiral,
it's a big black hole.

Speaker 3 (39:36):
No, it's it's the best business model in the world,
multi trillion dollar global economy. But what's the expense. The
expense is our own health and drugs have made.

Speaker 1 (39:48):
Okay, so let's go to the nasal the next I'm
heading down south.

Speaker 2 (39:52):
Okay, so we're going to end up at erectile dysfunction,
but I want to make sure we have time to
do it.

Speaker 1 (39:57):
So what about the nasal breathing and and versus the
mouth breathing. Why is that beneficial? And what can people
do to change their habit?

Speaker 3 (40:06):
Well, the same enzyme that's found in are endothelo cells
that produces nitrocoxide. The nitrocoxide synthase enzyme is also found
in our upper airways, the epithelial cells. So we do
nasal breathing, it activates these epithilal cells and turns on
nitro production. We do dasel breathing, we're actually delivering nitrocoxide
gas into the pulmary circulation, so we're dilating the pulmonary arteries.

(40:28):
Now we're matching ventilation to perfusion, and we're improving tissue oxygenation.
But it's also dilating the bronchiles. So nitrocoxide is a
smooth muscle relaxing, relaxes the smooth muscles on the blood vessels,
relaxes smooth muscles around the bronchiles. So now we're dilating
the bronochiles, dilating the arteries, improving oxygenation. But if the
enzyme is uncoupled and not functional, so if you have

(40:50):
nithenyal dysfunction, you have epithial dysfunction. And we tested this.
We take young healthy individuals do nasal breathing. We can
detect nitrocoxide out of the ease heal breath. We take
a fifty year old person with EED do nase of breathing.
There's no nitrocoxide. So again we have to focus on
restoring the function of the nos enzyme. Rgentie didn't go
fix it. Beats aren't gonna fix it. Centrally, it didn't

(41:11):
go fix it. I have to understand the enzomology about chemistry. Now,
if your mouth breathe, not only are you bypassing that
nitrocoxide production pathway, but now you're you're completely oxygenating the
oral cavity. You're changing the oral microbiome, You're acidifying the saliva.
All the nitrocoxide producing bacteria go away, all the pathogens
come in. Now you have chronic halatosis, you have an

(41:34):
acidic saliva, you have carrious causing bacteria, you have paradonal
disease causing bacteria. Performonis gingivite is all the really bad
red pathogens you see on dental pathogens and start to
show up. And you don't oxygenate at night, And so
I mean in ten time increase in all cause mortality
through mouthbreathing.

Speaker 1 (41:54):
So that means.

Speaker 2 (41:57):
What you do in the daytime, you know, you have
to be aware of that, but at night it's when
most people really are doing the wrong thing, which is
mouth breathing. So tape do mouth taping, which I read
about from a number of biological dentists that they're advocating that.

Speaker 1 (42:14):
So you can buy those you know mouth tapes and
use them.

Speaker 2 (42:17):
Are you advocating that as a as a methodology from
night for sleeping.

Speaker 3 (42:22):
Well, First of all, I encourage anybody who's a mouth
breathering to go see an airway specialist, either at an ear,
nose and throat doctor or a dentist who's an airway specialist,
because you don't want a mouth tape if you get
an anatomical obstruction, that's right. And because tape in your mouth,
I mean you could literally suffocate. You have to have
an airway for them to be oxygen exchange.

Speaker 1 (42:43):
That's right.

Speaker 3 (42:44):
Many people have anatomical issues, they have a small mouth,
you know, right, they have an obstructed airways. So first,
before you ever consider taping your mouth, go do the
airway specialists and make sure you don't have an obstructive
ay way. But yeah, if you've got if you've got
an open airway, mouth taping. I do it occasionally if
I'm outside I've got allergies and i feel a little snuffy,

(43:04):
but I've got an open airway, so I can do
mouth taping and you know, you feel the difference of
it the next morning.

Speaker 1 (43:09):
Yeah, for sure.

Speaker 2 (43:10):
I started doing it a little bit and it does
make a difference, and I think how deep you sleep?

Speaker 1 (43:15):
All right?

Speaker 2 (43:16):
So now next is the microbio the oral microbiome. So
can you give me a one minute description of how
the nitrocoxide influences the oral microbion.

Speaker 3 (43:26):
Well, the oral microbiome is influencing nitrocoxide production. So we
have what's called nitrate reducing bacteria that reduces nitrate to
electron reduction to nitrite. And now we swallow it's aliva
and make nitrocoxide. But without the bacteria, you know, we
lose the cardioprotective benefits of diet, we lose the cardioprotective
benefits of exercise. So when we do things like have

(43:48):
flouride in our toothpaste, which kills all the bacteria in
your mouth. When we use antiseptic mouthwashed, which two out
of three Americans usee mouthwashed everythy killing the bacteria, it
shuts down nitrocoxide production and your blood pressure goes up.
Blood pressure goes up, the number one driver, the number
one killer of men and women worldwide. So and we
and others a publish that if you destroy the microbiome,
it's causal for high blood pressure. So if you're using mouthwashed.

(44:11):
You have to stop, use a fluoride free toothpaste, and
then start doing things that restore and support the microbiome
instead of destroying them.

Speaker 2 (44:20):
You know, I'm so shocked when I go to these dentists,
I do you know, I have a biological I mean,
a regular hygiene and they're not. They're more you know,
in tune to allopathic approaches of but ye.

Speaker 7 (44:35):
So you know, they open up their cabinet at the
end of a session and they want to give you
a goodie bag, you know, to take home, and it's
flora tice paste.

Speaker 1 (44:46):
It's chloro hexacrene or whatever that mouth I mean, it's
all the stuff that's so.

Speaker 3 (44:52):
Bad for you.

Speaker 2 (44:53):
And then when you do any kind of procedure, they
want you to use an antibiotic.

Speaker 1 (44:58):
And that's the first thing they do when you.

Speaker 2 (44:59):
Walk is you know, they want It's like it's like candy,
and I always stuff them in my pocket.

Speaker 1 (45:05):
You know, they think I'm taking it, but I never do.
But you know, the these are the things to be
aware of.

Speaker 2 (45:12):
I mean, traditionally the dentists you're going to go to
most people are not going to biological dentists.

Speaker 1 (45:19):
So you're going to be offered. And then we still
have the government dealing with the fluoride in our water
and our and the truth pasted is just a byproduct
of that. So it's a it's a it's a slippery slope.

Speaker 2 (45:32):
I mean, you really, you have to navigate your own
journey and make your own decisions. But if anybody that's
watching today is still using mouthwash, alcohol based mouthwash, throw
it in.

Speaker 1 (45:47):
The trash, right, get rid of it. And and even
what do you think about oil pulling?

Speaker 3 (45:54):
Is that? Is that?

Speaker 1 (45:54):
Okay?

Speaker 3 (45:55):
The coconuta you know, the short answer is, we don't
know because we've never done the experiment. But you know,
I don't think it's an a septic. I think it's
a it's a good practice that many biological dyonists and yeah, recommend,
but I don't see any downside to it. But we
just don't know.

Speaker 2 (46:09):
Okay, So the next one down I'm saying would be,
uh oh, he's telling me hold on, okay, he's.

Speaker 1 (46:16):
Telling me we're out of time. Oh dude, Well you
know what, Nathan, We're going to have you back. I'm
so sorry. I wanted to go down through all the
you know, the.

Speaker 2 (46:25):
The organs and particularly the gut microbione and the heart
of course, and well and of course the erectile issue.

Speaker 1 (46:33):
But we'll make that happen in another session. Are you
okay with doing another.

Speaker 3 (46:40):
I love these conversations. These are very important conversations people
I know, and.

Speaker 1 (46:43):
You're doing such an important thing for all of us.

Speaker 2 (46:45):
Really, I just before we go, I really want to
just tell everybody if you want to order, and I'm
not everybody knows I'm not commercial, but when I take
a product and I know the difference, I want to
share it with other people. And I've been using since
I met you a year and a half, a little
over a year ago, I've been using your N.

Speaker 1 (47:06):
One oh one the Lozengers. That's the only product I
ever got, But I know you have many others. So
go check out.

Speaker 2 (47:13):
Nathan's website and Tony's our producer is going to put
it on the screen for everybody, and my assistant will
have it in the show notes. So if you want
to order any of his products, you can do so
using the affiliate My affiliate code with you right, which.

Speaker 1 (47:29):
Is gives you a ten percent So I will get
you the code.

Speaker 2 (47:33):
I don't have it right with me today, but we
will add that in so that people know how to
get your products.

Speaker 1 (47:39):
So Nathan, thank you so much. And I'm really sorry
I have to cut his short, but I love what
I think.

Speaker 2 (47:44):
We covered a lot of ground today and it's very,
very compelling information. So what you're doing is you're on
a mission and you have not deterred from your path.
You are an evangelist of outside and I truly, as
one individual, I truly appreciate your passion. So thank you again,

(48:06):
and and everybody check out Talk Doctor magazine coming up
in about another week or so.

Speaker 1 (48:12):
Okay, take care.

Speaker 3 (48:14):
Thank you,