ANTIDEPRESSANTS DURING PREGNANCY MAY ALTER FETAL DEVELOPMENT

Episode Transcript

Speaker 1 (00:00):
And a study done on SSRIs. Anxiety and depression during
pregnancy are recognizes major public health concerns. Depression and anxiety
i untreated to really affect both mother and fetus, especially
during pregnancy, so SSRIs and s NRIs are frequently prescribed
drugs to manage above conditions during pregnancy. However, these medications
affect the levels of neurotransmitters, and research is indicating now

(00:23):
that there's a potential impact on the development of the fetus.
Studies in maternal exposure to SSRISE and SNRI show possible
risks of offspring congenital cardiovascular abnormalities and anomalies of the
kidney and digestive system. Internal exposure to selective selective SSNRISE
and sensrized during pregnancy has been associated with certain adverse

(00:43):
pre perinatal outcomes, including pre term birth, low birth weight,
and neonatal adaptation. Center on exposures to SSRISE and SSNNRIS
also increases the possible risk of persistent pulmonary hypertension in
the newborn. However, evidence regarding long term nervaldevelopment outcomes remain unconclusive,
with studies showing mixed results. Because of the increasing occurrence

(01:06):
of maternal depression worldwide and the consequent usage of SSRIs.
There is an urgent need for additional data to better
understand the risk of developmental toxicity related to the use
of these antidepressants during pregnancy. The review aims to examine
the effects of SSRIs and SNRIs exposure during pregnancy on
fetal growth, post netal development, and long term reproductive outcomes.

(01:32):
In addition, another study showed in utero SSRI exposure altered
offspring brain and behavior. SSRIs can cross the placensa in
effect perinatal outcomes and infants. Recent studies suggest new risks
for long term behavioral, developmental and emotional disorders and offspring

(01:52):
studies show rates of miscarriage, birth defects, pre term birth,
newborn complications, and longer term neural behavior abnormalities are all
also associated with SSRIs and they can alter feedel development.
MRI studies show effects on brain size, structure, and function.
Serotonin plays a course in a crucial role in brain
development by impacting cell proliferation, migration, and brain wiring, and

(02:16):
there is much that is still unknown about the exact
mechanisms by which impact development. You know serotonin is active
in Fiel development SSRIs all to the serotonagic system and
therefore moms taking SSRIs could see alterations of the fetel development. Again,

(02:36):
there are several studies now that are being looked at
and just keep popping up. Of course, it leave it
onconclusive as we don't know for sure, but we do
see a lot of these studies starting to show up
more and more. That's it for now.