A Novel Approach to Advancing Breast Cancer Therapy

Despite availability of endocrine therapies for advanced or metastatic breast cancer, there remains a critical unmet need for more effective and convenient treatment options that improve both the patient experience and health outcomes.

In today’s episode of The Onco’Zine Brief, Peter Hofland, Ph.D. talks with Sean P. Bohen, MD, Ph.D., the president and Chief Executive Officer of Olema Therapeutics.

Olema Terapeutics is developing new treatment options designed to improve outcomes for women with metastatic breast cancer. The company’s lead investigational drug is OP-1250.
This drug is a is a novel agent with combined activity as both an advanced complete estrogen receptor antagonist, and a selective estrogen receptor degrader. This approach is expected to drive deeper, more durable responses than currently available therapies.

OP-1250 is currently in development as a treatment for estrogen receptor-positive, HER2-negative metastatic breast cancer (ER+/HER2- MBC), in both monotherapy and combination settings.

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Clinical trials
- Phase 1b Combo w/ Ribociclib and Alpelisib | NCT05508906
- A Phase 1 Study of Oral OP-1250 in Combination With Palbociclib in HR+/HER2- Breast Cancer Patients - NCT05266105
-A Dose Escalation/Expansion Study of Oral OP-1250 in Subjects With Advanced and/or Metastatic HR+, HER2- Breast Cancer - NCT04505826

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