Dr. Brendan McCarthy

Dr. Brendan McCarthy

Welcome! Dr. Brendan McCarthy founded Protea Medical Center in 2002. While he’s been the chief medical officer, Protea has grown and evolved into a dynamic medical center serving the Valley and Central Arizona. Through successful case after successful case, Dr. McCarthy has been dedicated to hormone balance, healthy metabolism, and the best quality of life. Dr. McCarthy’s hallmark is his unorthodox approach to mental/emotional wellness and its link to hormone balance in women and men. Through the use of blood work and clinical investigation, Dr. McCarthy gets to the bottom of possible causes for common conditions such as anxiety, PMS, depression, slow metabolism, weight gain, insomnia and now wants to share his knowledge to the viewers with his podcast. Join the discussion, ask questions, and welcome to the podcast!

Episodes

May 28, 2025 27 mins

Welcome to the podcast with Dr. Brendan McCarthy!

 

This episode takes you deep into the real-world practice of prescribing testosterone therapy for women.

This is not a high-level overview—this is a nuts and bolts breakdown:

✅ Who it's for

✅ How it's dosed

✅ What labs to run

✅ What delivery methods are safest

✅ Why it's often done wrong—and how to get it right

 

With over 20 years of clinical experience, Dr. McCarthy shares the i...

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Welcome to the podcast with Dr. Brendan McCarthy!

 

In this episode we dive deep into one of the most misunderstood and debated topics in hormone health: testosterone replacement therapy (TRT) for women. You may have heard horror stories—or glowing reviews. But what’s the truth?

Dr. McCarthy discusses:

- Why testosterone matters for women’s health

- How it affects brain chemistry, mood, bone density, and even breast tissue

- Its r...

Welcome to the podcast with Dr. Brendan McCarthy!

 

Today’s episode is all about testosterone therapy in women—a topic that’s often misunderstood, highly debated, and rarely taught in depth. I’m sharing what I’ve learned over my years of clinical experience, how I approach testosterone use in women safely, and why the conversation around it needs to evolve.

 

Dr. Brendan McCarthy founded Protea Medical Center in 2002. While he’s b...

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Welcome to the podcast with Dr. Brendan McCarthy!

 

Explore how progesterone travels through the body depending on the method of delivery—oral, transdermal, or injection. Dr. McCarthy explains why certain forms may not be effective for all patients and discusses how the body metabolizes progesterone, influencing its therapeutic impact. This episode is essential for anyone considering or currently on hormone replacement therapy.

 

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Welcome to the podcast with Dr. Brendan McCarthy!

 

Today’s episode is all about answering YOUR submitted questions — real concerns from real women — about hormone therapy, reverse responses to progesterone, MTHFR, estrogen detoxification, and more. This episode is packed with insights to help you better understand your body and your options. 

 

Dr. Brendan McCarthy founded Protea Medical Center in 2002. While he’s been the chief ...

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Welcome to the podcast! In this deeply personal Q&A episode, Dr. Brendan McCarthy—Chief Medical Officer at Protea Medical Center—responds to your most powerful and vulnerable questions about hormone replacement therapy, including:

- Why some women reverse-respond to progesterone

- What to do when testosterone creams trigger migraines

- How to safely navigate HRT with MTHFR or methylation issues

- The emotional toll of being dis...

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Welcome to the podcast with Dr. Brendan McCarthy! Welcome to Part 3. In this episode, Dr. McCarthy dives deep into the complex world of reverse responders—women who experience increased anxiety or worsened symptoms from progesterone instead of the calming effects it typically provides.

 

If you’ve felt forgotten or unsupported in your hormone journey—this episode is for you.

 

Dr. Brendan McCarthy founded Protea Medical Center in 2...

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Welcome to the podcast with Dr. Brendan McCarthy!

 

While progesterone is often prescribed for its calming and hormone-balancing effects, some women experience the exact opposite—increased anxiety, depression, and emotional instability. This phenomenon, known as reverse responding, is more common than many realize.

In this episode we explore:

The neurological effects of progesterone and why it can backfire

The role of allopregn...

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Welcome to the podcast with Dr. Brendan McCarthy!

Today he addresses a topic many women have been waiting to hear more about: why some people don't tolerate progesterone well.

Often overlooked in both conventional and alternative medicine, "reverse responders" experience heightened anxiety, insomnia, or mood shifts when taking progesterone — a reaction that defies the standard approach. Dr. McCarthy explores the science behind thes...

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March 28, 2025 30 mins

Welcome to the podcast with Dr. Brendan McCarthy! In this episode we're wrapping up our migraine series by answering your most frequently asked questions. Dr. Brendan McCarthy, Chief Medical Officer at Protea Medical Center, dives deep into the science behind progesterone, its effects on the brain, and why some people experience negative reactions. He also discusses estrogen therapy, common side effects, and why personalized medici...

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Welcome to the podcast with Dr. Brendan McCarthy! In this episode, we dive into the complexities of migraines, particularly the role of triptans in treating them. Dr. McCarthy addresses a common misconception about migraine pathophysiology, discusses the importance of lifestyle and genetic factors, and explains why understanding the root causes of migraines is crucial for effective treatment. He emphasizes the importance of a compr...

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Welcome to the podcast with Dr. Brendan McCarthy! In this episode we dive deep into the root causes of migraines in women, with a focus on the powerful role of progesterone and the GABA pathway. Learn why simply treating symptoms with medication isn’t enough and how understanding hormone balance can lead to long-term relief. This is part two of our migraine series, where we explore how estrogen and progesterone fluctuations impact ...

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Welcome to the podcast with Dr. Brendan McCarthy! In this episode we go over the connection between estrogen and migraines. He explores how hormone fluctuations can trigger migraines, the role of serotonin, and how proper medical testing can lead to better treatment options. Dr. McCarthy also addresses common failures in traditional medicine, the importance of a full neurological workup, and why balancing estrogen is key to overall...

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March 10, 2025 13 mins

Welcome to the podcast with Dr. Brendan McCarthy! In this episode we dive into headaches—particularly how women suffer from them more frequently than men. If you’ve been dealing with headaches that no one seems to understand, you’re not alone. This series is designed to offer insight and actionable advice, empowering you with the information you need to address the root causes of your pain.

 

Dr. Brendan McCarthy founded Protea Med...

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February 20, 2025 30 mins

Welcome to the podcast with Dr. Brendan McCarthy, Chief Medical Officer of Protea Medical Center in Tempe, Arizona. Your feedback and comments shape the discussions we have here—because your voice matters.

In this episode, Dr. McCarthy addresses some of the most common questions and misconceptions about menopause and hormone replacement therapy (HRT). He breaks down the science, clears up misunderstandings, and emphasizes the impor...

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Welcome to the podcast with Dr. Brendan McCarthy! We continue our menopause series as we dive into the treatment segment! Struggling with menopause symptoms like hot flashes, mood swings, or sleep issues? Hormone therapy (HRT) could be the solution! In this video, we break down how hormone treatment works, its benefits, risks, and who it’s best for. Learn the facts and take control of your health during menopause!

This is Part 2 of...

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Welcome to the podcast with Dr. Brendan McCarthy! We continue our menopause series as we dive into the treatment segment! Struggling with menopause symptoms like hot flashes, mood swings, or sleep issues? Hormone therapy (HRT) could be the solution! In this video, we break down how hormone treatment works, its benefits, risks, and who it’s best for. Learn the facts and take control of your health during menopause!

This is Part 1 of...

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Welcome to the podcast with Dr. Brendan McCarthy! Are you experiencing changes in your body and wondering if it might be menopause? I’ll guide you through the key signs and symptoms of menopause, the role of hormonal changes, lab values and how to approach an accurate diagnosis. Understanding your body is the first step to managing this transition effectively.

This is Part 2 of 4

 

Dr. Brendan McCarthy founded Protea Medical Center...

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Welcome to the podcast with Dr. Brendan McCarthy! In this video, I'm giving a brief overview of what women experience during menopause and trying to find proper treatment. From common symptoms to the changes your body goes through, this is the first step in understanding this natural phase of life. Stay tuned for more episodes where we’ll dive deeper into symptoms, diagnosis, and treatment options.

- This is Part 1 of 4 -

 

Dr. Bre...

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Welcome to the podcast with Dr. Brendan McCarthy! Autoimmune diseases can be complex and unpredictable, making treatment a significant challenge. From managing symptoms to addressing root causes, we uncover the hurdles in combating these conditions. How doctors should truly be helping YOU. Join me as we shed light on this crucial topic. Don’t forget to like, subscribe, and share your thoughts in the comments below!

This is a contin...

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