BIOACTIVE

BIOACTIVE

Dr. Riley Kirk is a cannabis research scientist and educator. She obtained her Ph.D. in pharmaceutical sciences, specializing in natural product chemistry, studying the traditional and contemporary uses of hundreds of medicinal plants. She is currently an assistant associate professor at the University of Rhode Island, has worked as an immunology scientist in the biotech industry, and works in the cannabis industry studying the chemical complexity of cannabis smoke. Riley is also the co-founder of the cannabis research and education non-profit organization called the Network of Applied Pharmacognosy (NAP). Through NAP and on her podcast, Riley uses science as advocacy to research and communicate findings that highlight the unique power of natural products. The goal of Riley’s work is to unite people in the Cannabis industry, academia, and consumers to further the reach of Cannabis education and reduce harm. Riley is passionate about making Cannabis science accessible through social media channels and alternative media which lead to Bioactive; an educational podcast which disseminates the chemistry and pharmacology of natural products. On this bi-weekly podcast, she covers current news and research surrounding cannabis, psychedelics, toxins, pharmaceuticals & other bioactive substances. Listen for special guests highlighting community stories.

Episodes

October 17, 2025 48 mins
CONTENT WARNING: IF YOU HAVE STRUGGLED WITH A DIFFICULT BIRTH EXPERIENCE THIS STORY MAY NOT BE BENEFICIAL TO LISTEN TO Dr. Riley Kirk shares her postpartum journey, discussing her high-risk pregnancy due to ICP, the challenges of early induction, and her return to cannabis use for mental well-being. She emphasizes the importance of self-advocacy, mental health, and the healing power of cannabis, while also expressing gratitude for...
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Dr. Riley Kirk welcomes international cannabis consultant, researcher, and author Russ Hudson to explore the fascinating world of flavonoids—an often overlooked but powerful group of compounds found in cannabis and everyday foods. In this episode, Russ shares his journey from the underground cannabis market to scientific research, and together they break down what flavonoids are, how they impact plant color, health, and resilience,...
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In part two of Dr. Riley Kirk's conversation with Dr. Janice Makela, MD, they delve into the complexities of cannabis use among the elderly, discussing its potential benefits and risks for sleep and mental health matters. The conversation also covers the importance of low dosing, the role of the endocannabinoid system, and the challenges of integrating cannabis into traditional medical practices. Big thanks to Dr. Janice for answe...
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Host Dr. Riley Kirk is joined by Dr. Janice Makela, MD for part one of a two part episode; the conversation was so interesting they couldn't cut it short! They discuss the evolving landscape of cannabis medicine, particularly for the geriatric population. She emphasizes the importance of education for both patients and physicians, addressing common misconceptions and the need for responsible dosing. The discussion covers various ...
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In this episode of the Bioactive Podcast, I sit down with Jürgen Bickel, Managing Director and Co-Founder of STORZ & BICKEL,  the legendary German company behind the Volcano, Mighty, Venty and Crafty vaporizers. We dive deep into: - What dry herb vaping is and how it works - Why vaporizing cannabis may be a healthier option compared to smoking - The science behind medical-grade vaporizers and what makes STORZ & BICKEL devices trus...
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Devin Melnyk shares his journey from the gray market of cannabis cultivation to working with one of the largest licensed producers in Canada. He discusses the evolution of the cannabis industry, the differences between the Canadian and U.S. markets, and the importance of community in cannabis culture. Devin also tells us about the new HiNote app, designed to help users track their cannabis experiences and connect with others in the...
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This week we are headed to Germany, this podcast was recorded at the world's largest cannabis expo called Mary Jane Berlin. I had the opportunity to jointly host and record a podcast with Lauren Avenius, the CEO of Node Labs. She is doing some ground breaking work with cannabis breeding and genetics and is doing an amazing job connecting people across the industry. Her work also encompasses other companies like Four20Pharma and Com...
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In this conversation, host Dr. Riley Kirk and guest Dr. Jaap De Roode discuss the fascinating field of zoo pharmacognosy, exploring how animals medicate themselves using natural substances. He shares insights from his research on monarch butterflies and honeybees, highlighting the role of toxic compounds and fungi in animal health. The discussion also touches on the implications for agriculture, the importance of biodiversity, and ...
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Join us for a deep dive into the world of cannabis science with Dr. Miyabe Shields and host Dr. Riley Kirk cofounders of the Network of Applied Pharmacognosy. NAP is a nonprofit focused on studying the real world uses of cannabis and other natural products as well as the biochemical mechanisms. In this episode, we discuss the latest updates on biochemistry projects, the importance of enzymes in the endocannabinoid system, and th...
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In this conversation, Dr. Michele Ross discusses the complexities of cannabis use during pregnancy, sharing her personal experiences and insights as a neuropharmacologist and fibromyalgia patient. The discussion highlights the lack of comprehensive research on the effects of cannabis, the comparative safety of cannabis versus traditional medications, and the stigma surrounding its use. Dr. Ross emphasizes the importance of advocacy...
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In this episode, Riley Kirk shares her personal journey through pregnancy, focusing on her experiences with cannabis use, tapering down her consumption, and the emotional and physical changes she faced. She discusses the importance of mental health during this time, the role of her supportive partner, and the diagnosis of intrahepatic cholestasis of pregnancy (ICP). The conversation also touches on the gender reveal process and ...
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In this conversation, Host Dr. Riley Kirk and Dr. Anurag Agrawal discuss the intricate relationship between monarch butterflies and milkweed, exploring themes of coevolution, chemical ecology, and the ecological arms race. He explains how monarchs have adapted to survive the toxic compounds in milkweed, the challenges they face due to habitat destruction and pesticides, and the importance of conservation efforts. The discussion hig...
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In this episode of the Bioactive Podcast, Dr. Allyn Howlett—renowned neuroscientist and pioneer in cannabinoid research—shares her groundbreaking journey into the study of cannabis and the discovery of the CB1 receptor. Originally focused on neuronal hormones, Dr. Howlett recounts how her curiosity led to one of the most pivotal findings in medical cannabis science: the identification of the brain’s first cannabinoid receptor. She...
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In this conversation, Dr. Riley Kirk and Dr. Josh Kaplan delve into the complexities of cannabis research, particularly focusing on CBD and its therapeutic potential for conditions like epilepsy. Dr. Kaplan shares his journey into cannabis research, highlighting the significance of understanding CBD's mechanisms, the role of GPR55 in seizure management, and the challenges of dosing CBD effectively. They also discuss the entourage e...
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In this episode of the Bioactive Podcast, Dr. Riley Kirk interviews David Sandelman from Cannatrol, delving into the intricate processes of drying and curing cannabis. David shares his journey into the cannabis industry, emphasizing the importance of controlling environmental conditions to achieve optimal drying and curing results. The conversation explores the science behind water activity, the significance of terpene retention, a...
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In this conversation, Jordan River shares his journey into the cannabis industry, emphasizing the importance of home growing and the concept of Overgrow, which advocates for more individuals to cultivate their own plants. He discusses the therapeutic benefits of cannabis, the connection to nature, and the role of caregivers in supporting patients who cannot grow for themselves.  The conversation highlights the value of homegrown c...
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In this episode of the Bioactive Podcast, Dr. Riley Kirk and Dan Nelson from Happy Valley Genetics discuss the importance of home growing cannabis and the various types of seeds available. They delve into the differences between photoperiod and autoflower seeds, the benefits of feminized seeds, and what beginner growers should consider when selecting seeds.  The conversation also touches on the evolution of cannabis genetics and t...
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In this episode of the Bioactive Podcast, Dr. Riley Kirk speaks with Dr. June Chin, Chief Medical Officer at Leafwell, about the evolving landscape of medical cannabis.  They discuss the benefits of obtaining a medical card, the differences between medical and recreational cannabis, and the challenges faced by patients, including cost and accessibility. The conversation also delves into the sensitive topic of cannabis use and fire...
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In this episode of the Bioactive Podcast, host Dr. Riley Kirk sits down with Elizabeth Sage who is a certified Ganjier- which is essentially the weed equivalent to a sommelier in the wine world. In this conversation, Riley and Elizabeth delve into the intricate process of evaluating cannabis, discussing various aspects such as appearance, grinding techniques, flavor profiles, and the importance of set and setting in consumption. ...
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In this episode of the Bioactive Podcast, host Dr. Riley Kirk dives deep into groundbreaking cannabis science with world-renowned molecular biologist Dr. Ali Bektaş. Dr. Bektaş has an impressive background in plant biology, microbes, and agriculture, specializing in affordable and distributed systems for detecting nucleic acids in agricultural environments. He has worked extensively with cannabis nurseries and biotech companies as ...
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