The Human Upgrade: Biohacking for Longevity & Performance
For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio, he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization. Each episode explores cutting-edge science, advanced technology, and proven biohacks to help you upgrade your energy, focus, metabolism, and resilience. You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakthroughs in mitochondrial health, peptides, hormones, fasting, sleep, neuroplasticity, and more. This isn’t just self-improvement - it’s human enhancement backed by data. Every guest, every idea, every protocol you discover here moves you toward a longer, stronger, smarter life. Join The Human Upgrade™ with Dave Asprey - and learn how to live longer, think faster, and perform better.
Episodes
Your muscles play a far bigger role in aging than most people realize. As you get older, the energy factories inside your muscle cells begin to break down and stop getting replaced, leading to fatigue, weakness, and slower recovery even if you stay active.
This video explains how that decline happens, why it accelerates after midlife, and what actually restores cellular energy instead of just masking the symptoms.
By underst...
This episode covers:
• Longevity Influence In The Epstein Files
A new DOJ document release tied to the Epstein investigation pulled physician and longevity influencer Peter Attia into the spotlight, after reports showed he appeared in the files more than 1,800 times and CBS News pulled a planned rebroadcast of its 60 Minutes profile. Dave breaks down why this story matters beyond headlines: lon...
18-year-olds wake up fresh because their repair system still works. This episode shows you how stem cell decline quietly drives fatigue, inflammation, and faster aging, and how fasting can reactivate your body’s natural ability to repair itself without expensive stem cell procedures.
Grab a generous 30% discount on any STEMREGEN product with: http://stemregen.co/dave30
Dave Asprey sits down with Chri...
STOP intermittent fasting if you think it automatically keeps you young. In this episode, you’ll learn why short-term fasting results can mislead long-term aging outcomes, and how duration, frequency, refeeding, and protein intake determine whether fasting supports longevity or quietly accelerates decline.
Watch this episode on YouTube for the full video experience:
Most people think aging starts with wrinkles, gray hair, or memory loss. It doesn’t.
Aging starts when your legs begin to weaken, long before you notice it.
In this video, you’ll learn why your leg muscles age faster than the rest of your body, how damaged mitochondria silently drain your strength, and why traditional solutions like exercise and protein stop working after 40.
You’ll also discover the one cellular proc...
In the late 1990s, a strange carbon molecule quietly delivered the single longest lifespan extension ever recorded in mammals. The rats lived about 90% longer, and almost no one was paying attention. This episode breaks down what that molecule is, why it works, and how it may upgrade mitochondria, sleep, and human performance when used correctly.
Watch this episode on YouTube for the full video experience:
Aging is not something Zoltan Istvan plans to accept quietly. He wants to treat death like a technical bug, rewrite the rules of biology, and turn California into the global test bed for radical human upgrades. From cyborg implants to AI driven longevity science, this episode explores what happens when a candidate for governor openly argues that humans should evolve beyond their biological limits and take control of how lo...
Your butt is not about aesthetics. It is a longevity organ that directly impacts metabolism, brain optimization, resilience, and how long you stay strong as you age. In this episode, you’ll learn why strength training and protein intake matter more than body fat percentage, how mitochondria drive human performance and recovery, and why building muscle protects your brain, stabilizes mood, and supports l...
Your gut already has its own version of Ozempic, and it’s been doing this job long before injections existed.
In this video, I explain how appetite is actually regulated, why synthetic shortcuts often create new problems over time, and what has quietly shut down the body’s natural satiety signals for so many people.
Once you understand the pathway drugs are trying to imitate, the question stops being “how do I eat le...
This episode covers:
• Real Food Reset in U.S. Dietary Policy
The new Dietary Guidelines for Americans 2025–2030 put real food back at the center of U.S. nutrition policy and take a direct swing at ultra processed foods, added sugar, and sugary drinks. Dave breaks down why this matters beyond personal dieting: these guidelines influence school meals, SNAP and WIC, federal feeding programs, and they ...
Most brain decline, mood instability, and impulsive behavior start with a breakdown in how the brain’s immune cells produce and use energy. This episode shows how mitochondrial health inside microglia influences cognition, emotion, and long-term brain resilience, and how everyday inputs quietly push those systems toward damage or repair.
Watch this episode on YouTube for the full video experience:
Your body does not fail all at once. Aging starts when cells quietly shift into survival mode and never come back out. In this episode, you go inside the thinking of a true medical outlier to understand how stress, travel, toxins, and metabolic overload reprogram cells, shut down energy, and accelerate aging, and how restoring mitochondrial function can reverse that trajectory from the inside out.
Watc...
One freezing sip on a Tibetan mountain rewired his hunger, silenced cravings, and unlocked a kind of fat-burning “switch” no doctor ever mentioned. What happened next—Silicon Valley obsession, a global butter shortage, and a new theory of weight loss—might change how you see food forever.
The only coffee I drink: Danger Coffee: https://dangercoffee.com/DAVE15
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This drug has been misunderstood for decades, and that confusion is costing people focus, learning speed, and cognitive performance. In this episode, you’ll learn why nicotine itself is not the problem, why delivery method and dose change EVERYTHING, and how oral nicotine can be used strategically for biohacking brain optimization, neuroplasticity, and human performance in a healthy and safe way.
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Most people are struggling in modern relationships, and it is not because they are broken. It is because the systems around them are. In this episode, you’ll learn why roughly 65 percent of people operate from insecure attachment, why that quietly destroys energy, trust, and intimacy, and how secure attachment becomes a critical biohacking upgrade for human performance, longevity, and emotional resilien...
Mood, motivation, and emotional resilience are not personality traits. They are biological systems. In this episode, you’ll get the 12 greatest mood boosters on Earth, not as a clickbait supplement list, but as the real biological levers that control dopamine sensitivity, hormones, neuroplasticity, and energy production.
Watch this episode on YouTube for the full video experience:
Most people think fasting is just about skipping breakfast. But what if 72 hours without food could actually reverse aging?
In this video, Dave Asprey breaks down what really happens when you fast for 3 days—and why short fasts don’t reach the deep repair zone your body is built for.
Thank you to our sponsors!
-HeartMath | Go to https://www.heartmath.com/dave to save 15% off.
Back in 2024 with Calley Means at South by Southwest, we sat down and talked about his mission to flip the old American food pyramid upside down for the greater good. Well guess what, the pressure is finally working! This rerun is the ultimate receipt that focus, repetition, and smart lobbying for human health can still move the needle!
Host Dave Asprey sits down with Calley Mean...
Creatine is a hot subject right now, but I’m guessing you might not know as much about it as you could. Well step into a new creatine masterclass with our friends from Qualia. This episode shows you why it is not just for muscle, but one of the most powerful and well studied upgrades for brain energy, metabolism, sleep resilience, and long term human performance. You will l...
You’re about to hear one of the most honest longevity conversations ever recorded. This co hosted episode brings together two longevity leaders with opposing views on how long humans can live, yet enormous respect for each other and the science. Recorded live at Eudemonia, this discussion gives you clear frameworks for longevity, biohacking, human performance, and anti aging without all the tr...
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