Endgame with Amanda Cassatt

Endgame with Amanda Cassatt

The world is changing at an accelerating pace—Endgame is here to make sense of it. Hosted by Amanda Cassatt, founder of Serotonin, this podcast brings you conversations with the visionaries driving breakthrough technologies and shaping the future. Join Amanda as she unpacks the trends, innovations, and paradigm shifts defining our time. Where is this all going? Let’s figure it out together. Subscribe now on Apple Podcasts, Spotify, YouTube, and wherever you listen.

Episodes

June 8, 2026 42 mins

Toby Shorin, cultural theorist and essayist, argues that the biggest threat of our time isn’t AI taking your jobit’s the optimization mindset turning every natural human impulse into a protocol to follow.


In this episode, we discuss:

  • Why the embodied turn in culture goes way beyond peptides and biohacking

  • The real difference between a protocol and a practiceand why it has political consequences

  • Who actually benefits from the lo...

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Your identity, your assets, your privacy, do you actually own any of it online? 

Binji Pande from the Ethereum Foundation says no. And he's spent his career trying to change that. In this episode, Amanda sits down with Binji to explore why crypto is really about redesigning human incentives, what digital rights actually mean, and what it would take to build a world where freedom online isn't a privilege.


Timestamps:

00:00 ...

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Everyone in crypto is chasing TPS

Eunice Giarta thinks that's the wrong race entirely

As co-founder of Monad Foundation, she spent four years building what she calls the Ethereum of high-performance blockchains  a chain with validators on six continents, in 30 countries and 58 cities, that doesn't sacrifice decentralization for speed.

In this episode of Endgame, Amanda Cassatt sits down with Eunice to break down what actually ...

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“A lot of users don’t need a bank. What they need is a wallet.”

In this episode of Endgame, Amanda Cassatt sits down with Richard Teng, CEO of Binance, for a conversation about what crypto actually became and whether that’s the right thing. Richard spent three decades in traditional finance, including the Central Bank of Singapore, before joining Binance in 2021. He doesn’t argue like a convert. He argues like someone who watched th...

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“The block explorer is your x-ray machine. Open it up, and you find rooms full of people.”

In this episode of Endgame, Amanda Cassatt sits down with Austin Federa, former Head of Strategy at Solana and co-founder of DoubleZero, for a rare, candid conversation shaped by shared history on opposite sides of the Ethereum–Solana divide.

They unpack the real meaning of decentralization: is it a philosophy, a design choice, or just branding...

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In this episode of Endgame, Amanda Cassatt cuts through the AI hype to explore what happens when creation becomes free. The result isn’t less competition—it’s more noise. She unpacks a web flooded with AI content, misaligned platforms, and the rising value of curation, taste, and real skill.

From the future of digital work to the surprising role of crypto—where AI agents, stablecoins, and frictionless UX may finally unlock DeFi—this...

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“The scammy elements of crypto are turning people off—and that’s something we need to fix.”

In this episode of Endgame, Amanda Cassatt sits down with Yat Siu, co-founder of Animoca Brands, to unpack crypto’s evolution—from idealism to hype cycles—and what comes next.

They explore AI agents, the open metaverse, and who actually benefits as technology scales. Yat argues blockchain was built for a future of billions of AI agents—and we’...

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Most of the people running the world are not evil masterminds; they are sincere operators trapped in an “epistemic maze.”

In this episode of Endgame, Amanda Cassatt sits down with Curtis Yarvin to explore why the rules-based international order was always fragile and how elite decision-makers operate on unexamined assumptions. They unpack Yarvin’s “interchangeable baby theory,” the 20th-century belief that human outcomes are largely...

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"If you are using technology to manipulate other people, you should be ashamed of yourself."In this episode of Endgame, Amanda Cassatt sits down with George Hotz to explore when technology empowers and when it traps. Using the framework of finite and infinite games, they define manipulation as placing someone in a system designed to extract from them without their awareness.They examine algorithmic trading, behavioral bet...

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As artificial intelligence agents become the dominant interface to the web, the question is no longer just “Who are you?” but “Who is acting on your behalf?”

In this episode of Endgame, Amanda Cassatt sits down with Billions Network CEO Evin McMullen to examine the rapid shift toward agent-mediated internet use. At the end of last year, roughly one in every 31 website visits was conducted by a non-human actor, up sharply from just ...

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As artificial intelligence becomes the dominant interface for work, creativity, and competition, some people are adapting to it far faster than others.

In this episode of Endgame, Amanda Cassatt sits down with Dragonfly Capital’s Haseeb Qureshi to explore a generational shift in technological advantage: the biggest winners of every major tech transition are not the most experienced, but the most “pluripotent.”

Younger people, who ha...

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Technology is the most powerful force in history, and whether it liberates or consumes us depends entirely on how aligned it is with human agency.

For Amanda Cassatt, this belief underpins her techno-optimism: the conviction that progress must be actively built, not passively awaited. In this solo episode, she explains how she sees technology as upstream of culture, economics, and politics, and views optimism as a necessary stance f...

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As nation-states double down on borders, nationalism, and readiness for war, some people are choosing not to wait around to see how that ends.

Amanda Cassatt sits down with Timour Kosters, who worked alongside Vitalik Buterin on Zuzalu, and co-founder of Edge City, a borderless pop-up society where highly driven builders, thinkers, and creators experiment with life beyond the nation-state. Emerging directly from the Zuzalu experimen...

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What if aging and reproduction were engineering problems, not biological limits?

In this episode, Amanda Cassatt sits down with AthenaDAO founder Laura Minquini to unpack how reproductive biotech could transform same-sex reproduction, family structures, and the future of population growth.

Laura explains how AthenaDAO and the DeSci movement are using crypto to fund research that has previously not been prioritized by the FDA or mains...

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What is the future of Arbitrum now that L1 Ethereum is becoming scalable?

In this episode, Amanda Cassatt sits down with Offchain Labs and Arbitrum co-founder Steven Goldfeder. Arbitrum began as Ethereum’s scaling answer, borrowing its security to add more bandwidth, faster confirmations, and better UX. As Ethereum solves the scalability problem that was Arbitrum's original raison d’être, Steven explains Arbitrum's next fron...

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January 14, 2026 46 mins

What happens when crypto stops optimizing purely for profit and starts optimizing for people, planet, and long-term coordination?

In this episode, Amanda Cassatt sits down with Gitcoin founder Kevin Owocki to discuss Ethereum’s public goods, swallowing the Green Pill, and what onchain coordination will look like in the future.

Owocki maps the cultural fault lines inside Ethereum: the libertarian and cypherpunk roots, the rise of hype...

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Crypto was supposed to be the escape hatch. So why does it increasingly feel like it’s being absorbed by the very systems it set out to challenge?

In this candid conversation, Amanda Cassatt sits down with cyberpunk crypto lawyer Gabriel Shapiro about the “fintech-ization” of crypto, where the industry stands in the post-Gary Gensler era and the fading relevance of the four-year cycle.

Is crypto a tool for resisting power, or just a ...

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Is crypto’s biggest rival artificial intelligence? 

As AI absorbs talent and capital, it’s not clear yet if crypto and AI are competing or converging but crypto’s focus on human agency may matter more than ever in an automated world.

Amanda Cassatt is joined by Aaron Wright, crypto lawyer, former Wikia general counsel and CEO of Tribute Labs, to unpack the battle between crypto and AI and what the explosive growth of stablecoins actu...

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What if the biggest forces shaping crypto today are hidden behind VPNs?

In this episode of Endgame, host Amanda Cassatt sits down with Mable Jiang, Trends co-founder, former Multicoin partner and founding member of the Solana Foundation Council,for a rare, unfiltered look at the Chinese and Asian crypto markets — the traders, the memes, the exchanges, and the invisible liquidity that moves the entire ecosystem.

From the rise of Bybit...

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What happens when the country that taught the world inflation becomes the testing ground for the future of money?


In this episode of Endgame, Amanda sits down with Camila Russo, author of The Infinite Machine and founder of The Defiant, to trace how growing up in Latin America shaped her understanding of money, power, and why crypto matters long before the West noticed. Before becoming one of crypto’s most influential journalists, C...

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