Big Brains

They’re perhaps the oldest questions in the science: Why do we die? And could we find a way to live forever? But for decades, anti-aging research was a “backwater” of the scientific community, consider too fanciful and unrealistic. That is until the last few years. Modern advances in biology have taught us a lot about how we age and why we die—could that knowledge help us turn back the clock?

In his new book, “Why We Die: The New Sc...

Every dog owner has faced the hard realization that their dog won’t live as long as they do, but we’ve all probably wondered: Why do some dogs live longer than others? It turns out that several factors are at play, according to the largest research study of dogs, known as The Dog Aging Project.

Prof. Daniel Promislow of the University of Washington is co-director of the project, which examines how biology, lifestyle and environment ...

For more than a century, scientists have been studying Alzheimer’s disease and developing theories about its underlying cause. The leading theory for decades has been that abnormal amyloid plaques in the brains of those who suffer from the disease are the central cause. But, according one renowned Alzheimer’s researcher, this myopic focus is not only flawed, but may be holding back our search for a cure. 

Neurobiologist Karl Herrup ...

Mosquito-borne diseases are one of the greatest global health threats, infecting around 700 million people every year with Zika virus, dengue fever, malaria and yellow fever — which can all be deadly if left untreated. Unfortunately, the mosquito population is not slowing down, and factors like climate change and increased global travel are broadening the mosquito's range. The effort to stop the mosquito is not an easy task; insect...

How do you stop a government from continuing to commit human rights abuses? You could take them to an international court of justice, or file a complaint at the UN. But none of those bodies have any enforcement power. Short of going to war, the only option on the table in most international situations is to name and shame. But is that strategy effective?

In her new book, “The Geopolitics of Shaming: When Human Rights Pressure Works ...

The Supreme Court’s decision on whether Colorado can take former President Donald Trump off the ballot in the 2024 election may be one of the most consequential in its history. The case will turn on the court’s interpretation of Amendment 14, Section 3 of the Constitution, which bars any previous elected official from holding office if they participated in an insurrection. When making their case, Colorado followed the logic of a la...

Language shapes our world. But when we speak, there is actually a secret conversation happening beyond our words. It’s happening not with our mouths—but with our hands.

Prof. Susan Goldin-Meadow is a distinguished scholar of psychology at the University of Chicago. Her research into deaf children who were never taught sign language led her to studying why the gestures we do all day may contain more information about our minds than w...

The United States is facing a real mental health crisis. In the last few years, one possible treatment has gotten a lot of press: psychedelic drugs. But what is actually happening in a person’s brain when they take a psychedelic? Could understanding the biology and the chemistry allow us to make better and safer versions of these drugs—and maybe even create psychedelics without the hallucinations?

In this episode, we speak with Asso...

The Big Brains team is taking some time off during the holidays but for all those travelers out there heading home, we wanted to make sure you still had your favorite podcast in your feed. So, we’re resharing one of our most popular episodes ever. It’s about the science of happiness.

What is the key to living a happy and fulfilling life? The answer is actually quite simple, according to the two scholars behind the longest scientific...

Here’s the question you’re going to be asking for the next 30 minutes: Did I freely choose to listen to this podcast, or did I actually have no choice at all? Most of us probably believe we have free will. We feel like we make decisions, and that each of us is responsible for the consequences of our actions. But what if that’s all just an illusion?

Robert Sapolsky is a renowned professor of biology and neurology at Stanford Universi...

Climate change can feel like an impossible crisis these days. Every week there is some new report about the irreversible damage we’re doing to our planet and the havoc it will bring to people’s lives. We all know cutting emissions is the solution, yet governments and companies seem no closer to meeting the goals that scientists say we must hit. It can feel hopeless.

There is one possible controversial solution to climate change many...

By now, you've probably heard about the dangers of PFAS “forever chemicals.” These chemicals are all around us—they're in waterproof hiking boots, electronics, nonstick pans and even our drinking water—but there's no way for them to break down in our environment. Epidemiological studies have linked to these chemicals to numerous diseases—from kidney cancer, liver cancer, obesity, decreased fertility and more.

American toxicologist L...

How many times have you heard this phrase: “Back in the day, people were nicer” or “People aren’t as kind as they used to be?” Most of us have experienced the feeling that people are becoming meaner over time, year after year. But is it true? Are people really less kind than they used to be?

That’s the question that has bothered psychologist Adam Mastroianni most of his life. He set out to find an answer—a search that recently culmi...

Of the academic books that have become household names, “Freakonomics” must be at the top of the list. The 2005 book by University of Chicago scholar Steven Levitt and journalist Stephen Dubner created not only a whole new way of thinking about discovering answers to complex problems, but launched a media empire—from book sequel to a movie to a hit podcast.

On this special episode, we sat down with Levitt during the inaugural UCPN P...

Since the Jan. 6, 2021 attack on the U.S. Capitol, University of Chicago Prof. Robert Pape has been closely observing the threats to our democracy. Now, the renowned terrorism expert says that violent ideas coming from a dedicated minority are moving from fringe to mainstream.

In 2021, Pape's team along with NORC at the University of Chicago launched the Dangers to Democracy tracker, an ongoing series of surveys to track Americans' ...

Free speech is probably one of the most polarizing public topics of debate. And those arguments only become more intense when it comes to free expression on college and university campuses. Should professors be allowed to say whatever they want? What about speakers being invited to campus? Who gets to say what is acceptable and unacceptable?

The University of Chicago has had a unique and long history of defending free expression, an...

Can you heal faster just by tricking your brain? Could you lose weight with only a change of mindset? Could you think yourself into being younger? If you think the answer to all these questions is no, you haven’t read the research from renowned Harvard University psychologist Ellen Langer.

Langer is a bit of a legend. She’s the first woman to ever receive tenure in psychology at Harvard, and her work has earned her the moniker: “The...

Reading is one of the most significant practices in the modern age of information, but it has a complicated history. Scientists began studying reading over a century ago; they built eye movement devices to study how fast and efficiently we read, and even proposed methods on the best ways to teach kids how to read. But all of this well-intentioned science led to various debates, from America's Reading Wars to today's anti-elite and ...

One of the first areas to be affected by AI has been science. Researchers have already started to integrate these new technologies into their work, but what does it mean to let these systems into our labs? Can they be trusted? And, if they so, how radically can they push science forward?

Prof. Rebecca Willett is the faculty director of AI at the University of Chicago Data Science Institute. She is at the forefront of thinking throug...