CancerCast

CancerCast

New scientific developments are transforming the future of cancer treatment and care. Hosted by world-renowned medical oncologist Dr. Manish Shah, CancerCast is your window into research breakthroughs, innovative therapies, and honest accounts of living with and beyond cancer.

Episodes

September 22, 2025
tumor-infiltrating-lymphocytes-til-melanoma-a-new-era-of-treatment

Tumor-infiltrating lymphocyte, or TIL, therapy is a new form of cellular immunotherapy that targets cancer cells by leveraging the body’s immune system and specialized cells called T-lymphocytes. This treatment is currently app...

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asco-2025-highlights

Drs. Manish Shah and Sarah Rutherford explore the groundbreaking research presented at the 2025 ASCO Annual Meeting. They discuss key developments from this year’s meeting, including new immunotherapy and targeted therapy options, the use of circulating tumor cell (ctDNA) ...

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transitions-reflections-and-the-future-of-cancer-care-and-research

A familiar voice in a new role. Drs. John Leonard and Manish Shah reflect on the past seven years of cancer care and research as Dr. Leonard passes the microphone over to Dr. Shah as the new host of Weill Cornell Medicine’s Can...

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November 26, 2024
leonard-list-2024

Join Dr. John Leonard for his special annual “Leonard List” episode. He shares his top 10 most interesting lymphoma and blood cancer-related abstracts to be presented at the 2024 American Society of Hematology (ASH) meeting. The ASH annual meeting...

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the-ins-and-outs-of-immunotherapy

Immunotherapy is a type of cancer treatment that helps your immune system fight cancer. In the last 10 years, immunotherapy has joined the list of standard cancer treatment approaches, alongside chemotherapy, targeted therapy, radiation therapy, and surgery. T...

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July 31, 2024
asco-2024-highlights

The American Society of Clinical Oncology, or ASCO, Annual Meeting is the largest global oncology conference and features state-of-the-art research presentations and cancer care insights from oncology professionals around the world. Every year on the CancerCast podcast, tw...

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pathology-s-place-in-cancer-care

Pathology has a crucial place in the medical field working behind the scenes to ensure patients and their care teams have the most up-to-date information. In cancer care, pathology plays an essential part in not only diagnosing cancer, but also treating and man...

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bone-breakdown-bone-health-cancer

The skeletal system keeps the body upright, but did you know that the bones play a number of pivotal roles in the body? From storing minerals to providing the home for new cell creation, the body’s bones are dynamic and critical to the body in various ways. Wh...

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diagnosing-and-treating-pancreatic-cancer

Pancreatic cancer can be a difficult cancer to diagnose and treat because symptoms don’t often appear until the disease is very advanced. New imaging techniques, personalized therapies and genetic knowledge are helping to change the landscape, as well ...

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November 29, 2023
leonard-list-2023

Dr. John Leonard shares his list of the 10 most interesting lymphoma-related abstracts to be presented at the 2023 meeting of the American Society of Hematology (ASH). The ASH annual meeting brings together blood cancer experts from around the world to present the most exciti...

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July 31, 2023
asco-2023-highlights

The 2023 American Society of Clinical Oncology, or ASCO, Annual Meeting brought together oncologists from around the world to share cutting-edge updates and scientific advancements. Every year, two of Weill Cornell Medicine’s top experts come together to discuss the latest...

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a-deep-dive-into-cancer-geneticsEvery child inherits a set of “germline” DNA from each of their biological parents. At times there are also mutations that are passed down. This differs from what are referred to as “somatic” mutations that are only present in cancer cells, but not in every cel...
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nutrition-advice-along-the-cancer-care-journeyNutrition plays an important role in cancer care, including helping people to navigate treatment side effects. Many people like to dish out diet advice, but for cancer patients, there are unique considerations to be mindful of before, during, and ...
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advances-in-colorectal-cancer-care-and-new-surgical-techniquesColorectal cancer is the third most commonly diagnosed cancer in the United States with an increasing number of new diagnoses under the age of 55. Screening guidelines continue to evolve in an effort to find these cancers at an ear...
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November 29, 2022
leonard-list-2022Dr. John Leonard shares his list of the 10 most interesting and impactful lymphoma and blood cancer abstracts to be presented at the 2022 meeting of the American Society of Hematology (ASH). This episode also features 5 “bonus” podcast-only abstract selections in addition to ...
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November 18, 2022
lung-cancer-an-overviewLung cancer is the leading cause of cancer death, yet it receives far less research funding than other common cancers, in part due to the stigma surrounding this disease. However, smoking is not the only risk factor – many patients are diagnosed with lung cancer who hav...
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October 21, 2022
detecting-breast-cancerBreast cancer screening aims to catch breast abnormalities and cancers early, often before the onset of physical symptoms. There are many tools available including mammography, ultrasound, and MRI as well as image-assisted biopsies. Depending on cancer risk, breast dens...
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chronic-lymphocytic-leukemia-cllChronic lymphocytic leukemia (CLL) accounts for about one-fourth of all new leukemia cases and diagnosis typically comes from routine bloodwork. While most cases result in a watch-and-wait strategy, understanding the underpinnings of this disease has helped adv...
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August 29, 2022
pain-managementPain is one of the most common, but complex symptoms for cancer patients. Both cancer and its treatments can cause pain and managing this pain is a personalized process. While there are numerous pharmacological and non-drug based approaches, improving pain can significantly imp...
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breaking-down-kidney-cancerKidney cancer is among the ten most common forms of cancer with about 79,000 new cases annually. It is often found incidentally but certain variables may increase risk, including factors such as family history, smoking, high blood pressure, obesity, and more. Kidney...
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