Should This Exist?

Renowned creator, entrepreneur and pioneer Caterina Fake brings together some of the most brilliant and visionary figures of our time, many of them friends and colleagues, for deep discussions about inspiration, humanity, technology, and the future of the world. With Ingenious, she explores the sources of inspiration and the hopes fueling luminaries working on the cutting edge of creativity, art, entrepreneurship, and tech...

If you love Should This Exist?, we have exciting news to share: From the same company behind our show, the podcast Spark + Fire is back for Season 2! Spark + Fire explores what really happens on the road to creative success. In their own words, creative icons share the moments of inspiration and setback, the collaborations and the pivots, the breakthroughs and the dead ends along the hero's journey to bring something new i...

You’d be forgiven for being surprised if your doctor wrote you a prescription for ecstasy, ayahuasca, magic mushrooms, or LSD. But a recent resurgence in psychedelic research shows that a number of mental health conditions can be treated directly and effectively with potent psychoactive drugs. Dr. Dave Nichols has been studying the chemistry of these drugs for over 40 years, and he’s convinced of their therapeutic potentia...

When you think of nuclear power, what do you envision? For many people, the answer is Chernobyl or Fukushima: massive meltdowns that turned vast areas into radioactive wastelands. But those were meltdowns — and without meltdowns, nuclear power could be a valuable source of clean energy. Dr. Jose Reyes, the co-founder of NuScale, has designed a small, modular reactor that, he claims, cannot melt down. A six-pack of these re...

Kelly Wanser is a climate activist who wants to use a strategy called cloud brightening to fight climate change, using a naturally occurring process to bounce rays from the sun back out to space. She and others have described it compellingly as “emergency medicine for the earth’s climate fever,” and suggest it could buy us more time to implement policies addressing the root causes of climate change. But climate change is a...

UCSF bioengineer Shuvo Roy and his team have created the world’s first bionic kidney. The coffee-cup-sized device includes a silicon nanotechnology filter to cleanse the blood, while living kidney cells grown in a bioreactor perform the other functions of a natural kidney. A bioartificial kidney could save kidney patients from being stuck on a dialysis machine for life – or dying while waiting for a rare transplant. But is...

Could you, would you, go one full hour without your phone? The average American spends one-third of their waking hours on a smartphone; we’ve been told our devices make life better, faster, and easier. What happens when we choose to live without them – or when we are forced to? In this episode, we’ll talk to media studies professor Douglas Rushkoff, get the down low from a U.S. senator who sat in a “digitally sequestered” ...

Standard college admissions tests are:

a. based on an outdated model of intelligence;

b. exclusionary;

c. a lucrative business and a near-monopoly;

d. all of the above.

28-year-old Harvard dropout Rebecca Kantar is disrupting the paradigm of pencil-and-paper tests like the SAT and ACT by designing interactive scenarios that play like video games, and that test for qualities like grit and creativity. But is another test the...

A VR system called Bravemind allows combat veterans with PTSD to confront and process their trauma in a virtual environment. The therapy, developed by psychologist Skip Rizzo, shows promise for PTSD and potential for other issues like phobias and addiction – and it may have applications to help healing more broadly. But does the potential for harm from virtual self-medication outweigh the good it can do in a clinical setti...

What if you could extend your healthy life by 10 or 20 years – with a blood transfusion from someone younger and healthier than you? Research by Stanford professor Tony Wyss-Coray shows potential to treat Alzheimer’s and prevent age-related cognitive decline: He’s discovered that proteins found in the blood of young mice can dramatically reverse the effects of aging when transfused into older mice. Doing the same thing in ...

Is it the loneliest idea you’ve ever heard? Or an ingenious hack that helps human caregivers be more attentive and empathetic? You might have these questions when you meet the robot caregivers who roam the halls at retirement homes, doing basic tasks for residents and keeping them connected. Is elder care something we want a robot to do? Roboticist Conor McGinn from Trinity College Dublin actually moved into a retirement h...

It’s one of the best weapons we have to contain a pandemic. But can it defeat the disease without spying on people who might carry it? MIT’s Kevin Esvelt has a bold idea: Let’s try a new form of contact tracing that could more than double the program’s impact. Bi-directional tracing looks both forward and backward from a known transmission, building a chart of the “undiscovered branches of the viral family tree,” and ident...

Chances are, you’ve seen a “deepfake” video. But did you know it? A new breed of tech detectives are building tools to spot these hyper-realistic videos – built with AI – where people say things they didn’t say or do things they’d never do. Some of these clips are just good, fanciful fun. But a deepfake deployed at the right moment could sway an election, or wreck a life. That’s why UC Berkeley professor Hany Farid is work...

How is technology impacting our humanity? It’s the question of our times. Join host Caterina Fake for Season 2 of Should This Exist – where each week we take a single technology and ask: What’s its greatest potential? And what could possibly go wrong? 

With fascinating guests telling great stories, we’ll talk about some astounding technologies. Robots who could become our caregivers in old age. Video games that aim to ...

The web is broken. Data is mined, sold, and exploited. Social media is an endless and biased scroll through the worst of humanity. Nobody’s personal information is safe. And worst of all, it’s inescapable. The web is a cornerstone of our lives. It’s how we work, communicate with each other, and get information. And it wasn’t supposed to be like this. How did a utopian vision of a free, open, and democratic internet turn in...

Imagine meeting your great-great-great-grandkids. Or going to law school in your 80s, learning to snowboard at 110, taking a gap decade instead of a gap year. Greg Bailey dreams of a world where everybody lives twice as long, and no one gets sick. His startup, Juvenescence, is developing a whole ecosystem of anti-aging medications to help you live longer, healthier. Which sounds great. But would this world of perky centena...

Imagine biting into a steak that didn’t come from a cow. Or a chicken breast that did not come from a chicken. Imagine if your favorite meat dish did not involve an animal getting killed. This is Isha Datar’s dream. She is a scientist on a mission to not only reinvent meat but the entire meat industry. If Isha's dream comes true, we'll live in a post-animal bioeconomy where animal products – from meat to leather and wool –...

Mike Pappas and Carter Huffman believe their invention fulfills the promise of the digital world: the complete freedom to design your identity. But what if we all used it? The human voice is a key marker of authenticity and individuality, and Modulate uses A.I to transform your voice into anything you want it to be. In real time. If you’re a woman and want to sound like a man, Modulate can help you. If you’re a teen and wa...

Kevin Esvelt knows the stakes are high. As a geneticist at the MIT Media Lab, Kevin discovered a technique called a gene drive, which gives humans a power we’ve never had before: to change the DNA of entire species in nature. This capacity is so new and so unprecedented that when Kevin made the discovery six years ago, it was “literally unimagined by any human being at that time — not in science fiction, not in any form of...