Y Combinator Startup Podcast

Last November, Peter Steinberger was annoyed that there was no good way to talk to his coding agents from his phone, so he built one himself. A few months later, OpenClaw had exploded into one of the biggest open source AI projects in the world, with nearly 3,000 contributors and a peak of 4.7 million weekly downloads.At Startup School 2026, Peter tells the story of what happened when OpenClaw took off, what he got wrong as it grew...

Science is building a retinal implant that restores vision to people who have gone blind. One patient has already used it to read a 300-page novel.Building a company like that requires a lot more than getting the technology right. At Startup School 2026, Science CEO Max Hodak explains how the company buys things and hires people, and why those systems determine how fast it can move.He also gets into why founders can’t delegat...

AI isn't just changing the tools designers use. It's changing how they build, ship, and stand out.

In this episode of Design Review, Stephen Haney, founder of AI-native design tool Paper, joins YC General Partner Aaron Epstein to demo the agent-first workflow that's making Paper one of the fastest-growing design tools since Figma.

Using live redesigns of user-submitted websites as examples, they break down the most common AI design...

The next generation of startups will be built by smaller teams than ever before.

At Startup School 2026, YC President & CEO Garry Tan explains why we're entering the era of personal AGI: AI agents that run on your own infrastructure, compound your knowledge over time, and dramatically increase your ability to build. He shares the tools and workflows he uses every day, why every founder should own their intelligence instead of re...

Philip Johnston is the co-founder and CEO of Starcloud, the company building data centers in space.

In November 2025, Starcloud launched an Nvidia H100 GPU into orbit and trained the first large language model in space. They've since raised $200 million, hit a billion-dollar valuation just 17 months after YC demo day, and filed with the FCC to deploy 88,000 more satellites.

In this episode, Philip walks us through their wild origin...

Waymo’s first autonomous demo took eighteen months. The product took fifteen years. Today, the Waymo Driver runs 500,000 trips a week — four million fully autonomous miles across fifteen cities, with 17 times fewer serious-injury crashes than human drivers.

At Startup School 2026, Waymo co-CEO Dmitri Dolgov shares the seven lessons behind that journey, from bridging the gap between a demo and a real product to building s...

In 2009, Patrick and John Collison went to Startup School in Berkeley, got sushi in Potrero Hill afterward, and decided on the walk home to start Stripe. The reasoning, as Patrick remembers it, was that “we might as well because it probably won't be that hard.”

It took two years to launch.

Seventeen years later, at Startup School 2026, he talks with YC's Harj Taggar about dropping out of MIT twice, why founders should ask...

In 2001, Jeff Dean and Sanjay Ghemawat did the math and realized Google’s entire search index would fit in RAM — then shipped it in a few days, and search got fast. In 2013, another napkin calculation showed that three minutes of daily speech recognition per user would require doubling Google’s server fleet. That one became the TPU.

At Startup School 2026, Google’s Chief Scientist talks with YC’s Diana...

In 1969, we landed on the moon and flew Concorde. Half a century later, we could do neither.

Blake Scholl founded Boom Supersonic (YC W16), the startup building America’s first supersonic airliner, to change that. At Startup School 2026, he shares how a cardboard mockup with Office Depot seats became XB-1, the first independently developed jet to break the sound barrier, and why founders have to build for both the worst day an...

NVIDIA started with the wrong technology, learned the right one from three textbooks bought at Fry’s, and went on to invent most of the major breakthroughs in modern computing.At Startup School 2026 at Chase Center, Garry Tan sits down with Founder and CEO Jensen Huang to talk about confronting reality, learning your way into new domains, and why resilience — getting through one day at a time — matters more than a...

Why do even our best AI models need tens of thousands of examples to learn skills that a human picks up in a handful of tries?Solving this problem is one of the great open challenges in modern AI. World models, which give AI an internal simulation of its environment, are one of the most promising paths forward.In this episode of Decoded, YC's Ankit Gupta and Francois Chaubard discuss the intuition and math behind world models, new ...

Most founders obsess over dashboards and aggregate metrics, but some of the best product insights come from understanding how individual users actually use their product.

In this episode of Startup School, YC's David Lieb walks through one of his favorite tools for better understanding your users, the dot plot. It's a simple two-dimensional grid that reveals usage patterns no aggregate chart can show you.

He’ll cover why it giv...

Bryant Chou co-founded Webflow, which today powers around 1% of all websites on the internet. Now he's back in the current YC batch with Ploy, an AI-powered website and marketing platform that doesn't just build your site — it connects to your analytics, CRM, and search console to optimize your marketing while you sleep. In this episode of the Lightcone he explains how he built Ploy to be “anti slop,” how building...

Many founders get stuck trying to find the perfect startup idea before they commit. But the perfect idea doesn't exist in the abstract. The only way to find what works is to pick one, go deep, and get feedback from real customers.

In this episode of Startup School, YC's Jon Xu breaks down how to choose what to build, "burn the other boats," and go deep enough to practically run your customer's business— and why that depth is w...

Brex co-founder and CEO Pedro Franceschi believes most people still underestimate how much AI will change the way companies are built. AI isn't just another tool, it's a new foundation for building products, teams, and companies.In this episode of Lightcone, Pedro shares why he thinks we're only months into a platform shift as significant as the invention of electricity, how AI has changed the way he works, and why every founder sh...

Some of the biggest companies of the next decade won't be software businesses, they'll be services companies like insurance carriers, law firms, and tax practices rebuilt from scratch with AI doing most of the work. In this episode of Startup School, YC Visiting Partner Charlie Warren walks through the playbook for building AI native services companies, covering how to pick a market with the right traits, why variance kills these b...