Boba & Biotech

Boba & Biotech

Boba & Biotech is a candid podcast about what it takes to develop new drugs and the ecosystem of academics, biotechs, pharma and investors behind it. Our field is often misunderstood by outsiders and insiders alike due to the poor communication habits and complex science that underlie human disease. I, Armon Sharei, was a PhD student in chemical engineering when I was first enamoured by the idea of engineering a patient’s own cells to attack their disease. Throughout my journey, we spun out a company, SQZ Biotech, from MIT, raised $400M in investor and partnered funding from Roche, and went public on the NYSE. Eventually my board and I had a big fight, I got kicked out and started all over again! Please join me as we chat with the people that have dedicated their careers to improving human health and how they navigate the challenges of science, money, corporate politics and the rollercoaster of clinical development. As we sip on our boba throughout these episodes, I promise the only sugar coating will be on the bubbles! Portal Biotechnologies, headquartered in Watertown, MA, is a rapidly scaling cell-engineering platform company redefining how scientists and clinicians engineer cells across research, drug discovery, and therapeutic applications. Since launching its first product in 2024, Portal has built a network of 100+ active customers, received an $8M contract from DARPA and been deployed in most of the top 10 global pharmaceutical companies and leading academic hospitals worldwide. Armon Sharei, PhD, is the Founder and CEO of Portal Bio. Previously, Armon founded and served as CEO of SQZ Biotech (NYSE: SQZ), where he raised over $400M, advanced three oncology clinical trials, established a $1B+ collaboration with Roche, and led the IPO. A Stanford and MIT graduate and former Harvard Postdoctoral Fellow, Dr. Sharei holds 30+ patents and has been widely recognized for his scientific and entrepreneurial leadership.

Episodes

June 18, 2026 32 mins
Guest: James Taylor In this episode of Boba & Biotech, Armon sits down with James Taylor, co-founder of Precision NanoSystems, for a candid conversation about building a platform technology for nanoparticle-delivered RNA medicines from a PhD project into an 11-year journey that ended in an acquisition by Danaher Corporation, a leading global life sciences and diagnostics healthcare company.  They cover the early grind of...
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Guest: Jason Kelly In this episode of Boba & Biotech, Armon sits down with Jason Kelly, co-founder and CEO of Ginkgo Bioworks, for a conversation about what it takes to build a biotech company from scratch when no one will fund you, why platform business models in biotech are harder than they look, and where he thinks the biggest opportunity in biotech history is hiding. They cover how Ginkgo got started on grants and stubbor...
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Guest: Mark Dempster In this episode of Boba & Biotech, Armon sits down with Mark Dempster, Co-Head of Healthcare Investment Banking at Stifel, to pull back the curtain on what biotech bankers actually do and why it matters more than most founders realize. They cover the public vs. private financing divide, why the stigma around banks helping with private rounds exists and whether it still makes sense, and what founders consi...
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Guest: William Pao  In this episode of Boba & Biotech, Armon sits down with William Pao, a physician-scientist who has run oncology R&D at Roche, served as Chief Development Officer at Pfizer, and is now CEO and Co-Founder of Revelio Therapeutics. Few people have seen drug development from as many angles. They get into the real economics behind why a single molecule can cost $600M to advance, what it actually feels l...
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Guest:Sophia Lugo In this episode of Boba & Biotech, Sophia Lugo and I grab some delicious boba teas to explore her unconventional path into biotech and the realities of building a company at the frontier of genetic medicine. From her early experiences across Harvard, China, and the Gates Foundation to co-founding Radar during her time at Stanford, Sophia shares how urgency, ambition, and a belief in personal agency shaped her...
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Guest:  Adam Jenkins What actually makes or breaks a biotech startup - and why is it rarely the science? In this episode of Boba & Biotech, Adam Jenkins and I enjoy some delicious grapefruit-coconut sago from Heytea while we discuss the hidden dynamics shaping today’s biotech ecosystem. From the inside workings of incubators like BioLabs and LabCentral to the uncomfortable truth about “zombie” startups,...
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Guest: Klavs F. Jensen  In this episode of Boba & Biotech, I sit down with Klavs Jensen - professor at MIT and former chair of its chemical engineering department - to explore a deceptively simple question: why do some scientific breakthroughs become companies while others never leave the lab? As we unpack the messy journey from academic discovery to startup, Klavs tries his first-ever boba tea, a refreshing mango green ...
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Guest: Soufiane AboulhoudaIn this episode of Boba & Biotech, over matching brown sugar milk teas (great minds, same taste), Souf Aboulhouda, co-founder of Nucleate, and I trace his journey from growing up between France, England, and California to pursuing a PhD in the Church Lab at Harvard - where he first stumbled into the world of biotech startups after watching labmates pitch to investors.  What began as a personal cr...
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Guest: Ileana Pirozzi  In this episode of Boba & Biotech, I grab a delicious mango-coconut sago with Ileana Pirozzi, a former biotech investor who’s stepping off the venture sidelines and into the founder seat. From growing up in Italy to studying biomedical engineering at Stanford and working at NASA, Ileana shares how venture capital became a crash course in scientific rigor and why it ultimately felt too distant ...
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In this episode of Boba & Biotech, I go for a tasty brown sugar milk tea with Martin Madaus, former CEO of one of the biggest technology providers in our field, Millipore, for a wide-ranging conversation on what actually creates value in life sciences. Martin traces his unconventional path from veterinary medicine to global leadership roles across pharma, diagnostics, and life science tools, and shares hard-earned perspective...
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In the pilot episode of Boba & Biotech, I try out a homemade milk tea with my long time friend and colleague, Shirley Mao. The goal of this episode is to invite listeners into my world - inside and outside of work - and to share the vision behind this brand-new podcast. It's also the fastest way to figure out if I’m boring or insufferable :) From an early interest in math and science, to Stanford, MIT, and the leap from ...
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Biotech has a PR problem. It's messy, complex, and hard to understand from the outside looking in. That's why I'm starting Boba & Biotech. I’m Armon Sharei. You might know me from my cell cartoons on LinkedIn. I was born in California, grew up in Iran and Dubai, and somehow ended up spending most of my life thinking about cells. In this intro episode, I'll lay out my career - how I got to where I am today. Hint: I&rsqu...
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