Best Friends with Nicole Byer and Sasheer Zamata

Best Friends with Nicole Byer and Sasheer Zamata

Gayle & Oprah. Bonnie & Clyde. Nicole & Sasheer. Enter the pantheon of best friendship. When you’re forced to change your number, are sick of being single, or want to take a pole-dancing class, you’re going to need a best friend...and if you don’t, you can still have this podcast. This is a Headgum podcast. Follow Headgum on Twitter, Instagram, and Tiktok. Advertise on Best Friends via Gumball.fm.

Episodes

March 4, 2026 72 mins

Nicole and Sasheer take a deep dive into Nicole’s latest passion - making her own ice cream at home! Our favorite best friends also discuss the evergreen hotness of Joe Pesci, Spider-Man’s goop and where it comes from, as well as Sasheer’s thoughtful gift for safekeeping Nicole’s extracted tooth. 

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Nicole and Sasheer are thrilled to welcome a very special guest, Nicole’s former roommate and Sasheer’s former co-worker, the incredible actor/writer/comedian John Milhiser (SNL, Drama Club)! Our trio takes a trip down memory lane to revisit apartments that are either windowless or haunted, consider the under-sung lesbian icon that is Clarabelle Cow, and find out the origin story of Nicole’s love for ricotta cheese. 

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February 18, 2026 61 mins

Nicole and Sasheer have so much to dish about this week, covering everything from the Black Eyed Peas and Vanilla Ice's decision making to revisiting one of the best legging reviews of all time. Nicole also brings a show-and-tell presentation for Sasheer that marks an important first for the Headgum studio - nothing like this has ever been done before!! Our favorite pair also gets into the NBA (as a company), tra...

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February 11, 2026 58 mins

This week on Best Friends, Nicole and Sasheer are locked in and ready to learn about everything from glittery lotion to snowboarding uphill. They also get into airport fashion, Nicole's original plan for her remains that also involves the airport, and Sasheer does a special ASMR session featuring Nicole's new bracelet.

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February 4, 2026 61 mins

This week, Nicole and Sasheer chat about Waymos (aka Vin Voms), reminisce about visiting a dangerous waterfall, practice eye strengthening exercises and make plans to go off-roading AND to the library in the same day. They also take a quiz to figure out what mystical creature they are!

QUIZ: https://www.buzzfeed.com/laughingbunny255/venture-through-a-mystical-forest-and-ill-say-if-fpjxac53e8

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January 28, 2026 65 mins

This week, Nicole and Sasheer take a trip down memory lane all the way back to Nicole's middle school cafeteria. Sasheer also shares her exciting cat update - welcome Sesame!! Our favorite duo also plans a potential getaway to the Poconos, so stay tuned for more developments.

Have an advice question for Best Friends? Email us at nicoleandsasheer@gmail.com or leave us a voicemail at (323) 238-6554‬

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Nicole and Sasheer are joined by a very special guest, comedian Aparna Nancherla! The trio gets into the concept of friendship hygiene, high school reunions, debunking myths about best friends and more. Check out Aparna's latest stand up special, Hopeful Potato, out on Dropout now!

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January 14, 2026 62 mins

It's a busy week in the Best Friends studio! Nicole and Sasheer get into their new year's resolutions, moon rituals, and their different perspectives re: frozen fruit. They also take a trip down vacation memory lane and get into how it is not a Party in the USA.

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Nicole and Sasheer are back with another extra-special episode of Best Friends! Our favorite duo gets into how they'd handle an extra-terrestrial encounter, what pirates are talking about when they say "shiver me timbers", and how everyone seems to be cutting corners lately except for Dave Thomas.

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December 24, 2025 68 mins

Happy Holidays from Best Friends! This week, Nicole and Sasheer get into the latest Avatar film, how they react differently during emergencies, and take the wildest quiz yet in the history of Best Friends!

QUIZ: https://ela-ine.github.io/what-vehicle-are-you/index.html

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Nicole and Sasheer are excited to welcome very special guest, filmmaker Paul Feig (Bridesmaids, Freaks and Geeks, A Simple Favor, Spy) to chat about his upcoming film, The Housemaid, which is in theaters December 19th! Our trio of friends discusses what makes a friendship movie great, a shared past passion for tap dance, and the best piece of test audience feedback Paul ever received.

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December 10, 2025 59 mins

Nicole and Sasheer are back for an extra special solo episode of Best Friends! Nicole gives the update on her latest apple discoveries and considers the best way to get backstage at Beyoncé. Sasheer gives a fantastic enactment of sitting in an exit row and important advice to a listener that involves sprinting towards a group of people. Get into it!

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December 3, 2025 60 mins

Nicole and Sasheer are back from a night out on the town to catch up with each other about kissing in the rain, the joy of lasagna, butt facials, neutering and Nicole's giraffe family.

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November 19, 2025 63 mins

Nicole and Sasheer are back with a special solo episode for your video watching eyes and podcast listening ears! They get into Nicole's latest musical fixation, Sasheer's cat's recent escape attempt, take a quiz and answer some questions from the lovely listeners.

Quiz Link: https://www.proprofs.com/quiz-school/story.php?title=pq-what-type-of-vehicle-are-you

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This week, Nicole and Sasheer are joined by best friends Betsy Sodaro (A Funny Feeling, We Love Trash) and Gilli Nissim (The Other Two, Twisted Metal, AP Bio)! The group gets into the story behind Betsy and Gilli's matching shirts, memories from their trip to Bulgaria where Betsy filmed a commercial playing an eye mite, and the absolute joy of living with a best friend!

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November 5, 2025 62 mins

Nicole and Sasheer are back in the studio to debrief Sasheer’s house project, uncover the origin story of cereal mascots, try a new quiz and answer some friendship advice questions from our gorgeous listeners.

QUIZ: https://www.autostraddle.com/quiz-which-classic-bath-and-body-works-scent-are-you/?results=44c723e2

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We have a very special guest this week - one of Nicole and Sasheer's best friends, actor and musician Tawny Newsome (Space Force, Star Trek: Lower Decks)! The trio gets into strength-training, the multitude of activities you can do outside with your friends, the joy of adult coloring books, and Tawny's memorable night on the town that solidified a best friendship.

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October 22, 2025 61 mins

Nicole and Sasheer are back from a quick trip to Vegas and ready to break down all of their funniest moments, from seeing Ashlee Simpson to their beloved Cirque Du Soleil. Nicole and Sasheer also recount their very different mornings - one involves the fire department (spoiler: everything's fine!) and the other involves stealing fruit. Tune in to find out what happened to who and why and how!

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This week, Nicole and Sasheer are joined by two very special guests and hosts of the podcast Sloppy Seconds, Big Dipper and Meatball! Our host duos discuss the ins and outs of working with your best friend, rumors regarding the cleanliness of restaurant ice, and play an exciting round of Besting Each Other.

Episode Quiz: https://www.buzzfeed.com/itztocaviolet/fruit-personality-quiz

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October 8, 2025 56 mins

Nicole and Sasheer finally take their first Buzzfeed quiz since the hiatus to figure out what fruit they are... but fair warning, it doesn’t go as expected. Also discussed are the many interpretations of the hugging emoji, going to the beach in New York, and ways to stay connected to friends while being in different life phases. 

Episode Quiz: https://www.buzzfeed.com/itztocaviolet/fruit-personality-quiz

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