Docs Who Lift

Takeaways:

Slimmer's Paralysis is a recognized condition.

Ethical boundaries are crucial in patient relationships.

Medical professionals must maintain professionalism at all times.

Humor can sometimes arise in serious discussions.

Patient stories should always be handled with care.

The importance of clear communication in medical settings.

Understanding patient experiences is vital for effective care.

Ethics in medicine is a complex and nu...

Takeaways:

Drug transfer during lactation is complex and challenging.

Semaglutide was not detected in women taking any dose.

Low amounts of tears epitide were found in milk.

Tissue damage can affect drug absorption.

Mastitis and engorgement complicate the lactation process.

Injections are necessary for effective drug delivery.

The analogy of an elephant illustrates the difficulty of drug transfer.

Detection of drugs in milk is a critical c...

Takeaways:

Behavior change is a complex process that requires understanding motivation and discipline.

Motivation is not just a feeling; it's a psychological skill that can be developed.

Many common phrases about behavior change are misleading and oversimplified.

Exercise should be viewed as a choice rather than a habit that becomes automatic.

Self-efficacy is crucial for successful behavior change and can be built through mastery exper...

• Testosterone therapy can improve libido in postmenopausal women.
• Sexual dysfunction in women is complex and multifactorial.
• Low sexual desire is only considered a disorder if it causes distress.
• Psychosocial factors play a significant role in sexual health.
• Testosterone levels do not change significantly at menopause.
• The placebo effect can significantly influence treatment outcomes.
• Individualized care is crucial in managing sexual ...

Show Notes:
In this episode of Docs Who Lift, the Nadolsky brothers welcome back Dr. Sean Wharton, clinical trialist and one of the leading researchers behind the next generation of oral GLP-1 medications. Together, they break down:

The OASIS-4 trial results on 25mg oral semaglutide and how it stacks up to injectable Wegovy

How orforglipron, Eli Lilly’s new small-molecule GLP-1, differs from peptide-based drugs

Why these new therapies ...

In this episode of Docs Who Lift, the Nadolsky brothers dive deep into the newly released American Association of Clinical Endocrinology (ACE) Algorithm for Obesity Care led by Dr. Karl himself. They explore:

Why ACE moved away from a BMI-only approach to a person-centered, complication-centric model

The new staging framework (ABCD) that helps individualize treatment intensity

How to interpret “clinical” vs “preclinical” obesity under...

Takeaways

• The book aims to dispel myths surrounding the Biggest Loser study.
• Miscommunication in media has led to public confusion about metabolism.
• Metabolic adaptation is a response to weight loss, not a determinant of it.
• Cultural factors significantly influence eating habits and food choices.
• The food environment plays a crucial role in dietary behaviors.
• Bipartisan support is necessary for effective food policy changes.
• Understan...

Takeaways

Menopausal women often prioritize weight gain concerns over other symptoms.

The study observed an association between hormone therapy and weight loss with GLP-1 medications.

Retrospective studies have limitations but can provide valuable insights.

Future research should focus on randomized controlled trials to confirm findings.

The relationship between estrogen and GLP-1 signaling needs further exploration.

Funding for researc...

Takeaways

• The podcast features Dr. Grant Tinsley, a body composition expert.
• The discussion revolves around a case series on body composition effects.
• GLP-1 receptor agonists are a focus of the research.
• The importance of resistance training in weight loss is emphasized.
• Patient case studies provide insights into individual experiences.
• The first patient lost a significant amount of fat mass while preserving lean mass.
• The second pati...

Takeaways

Direct-to-consumer lab testing is on the rise, with significant marketing efforts behind it.

Many patients feel brushed off by traditional healthcare providers, leading them to seek alternative testing options.

Communication between patients and healthcare providers is often inadequate, contributing to misunderstandings about health.

Over-testing can lead to unnecessary anxiety and misinterpretation of results.

Fitness influen...

In this episode of the Dr. Lift podcast, hosts Dr. Spencer Nadolsky and Dr. Karl discuss the recent changes in obesity medication coverage, particularly focusing on the CVS Caremark decision to drop ZEPBound from their formulary in favor of Wegovi. They explore the implications of this decision for patients and providers, the role of pharmacy benefit managers (PBMs) in healthcare, and the ongoing advocacy efforts to ensure access t...

In this episode of the Dr. Lift podcast, hosts Dr. Spencer Nadolsky and Dr. Karl discuss the Surpass CVOT trial, which evaluates the cardiovascular outcomes of Monjaro compared to Dulaglutide (Trulicity). They delve into the significance of the trial, the implications of the results, and the potential benefits of Monjaro for patients with type 2 diabetes and cardiovascular risks. The conversation highlights the importance of unders...

How the STEP-UP trial came to life,  and what made the 7.2mg dose possible

What the data actually says about weight loss and side effects at higher doses

Why trial design, pharmacokinetics, and estimands matter more than you think

What’s coming next in obesity meds: duals, triples, and even antagonists

The real talk on intermittent fasting, access issues, and preaching vs. science

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Takeaways

• The study examines the overlap between clinical and anthropometric obesity.
• Anthropometric measures include waist circumference, waist-to-hip ratio, and BMI.
• Challenges exist in applying the Lancet Commission's definitions in clinical practice.
• Metabolically healthy obesity is a debated topic in obesity research.
• The study highlights the importance of data from the All of Us Research Program.
• There is a significant prevalen...

Learn what age-related macular degeneration (AMD) is

What causes AMD

The types of AMD

The update on NAION - listen to last year's podcast all about it

Why we aren't too concerned

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• Menopausal hormonal therapy should not be a blanket recommendation for everyone going through menopause
• Weight management in women is influenced by hormonal changes throughout life stages.
• Retrospective analyses can provide insights but have limitations.
• The wellness industry often oversimplifies complex medical issues.
• Hormonal replacement therapy may have subtle benefits for weight management.
• Confounding factors like SSRIs can co...

• Dr. Grant Tinsley joins the discussion as the body composition expert.
• Myostatin is a key regulator of muscle growth.
• Wendy Whippete the most jacked muscled up dog
• The concern of GLP-1 receptor agonists and muscle mass loss.
• Overview of Courage trial looking at semaglutide and trevogrumab and lean mass loss
• Upcoming Believe trial coming out (bimagrumab and semaglutide)
• Exercise remains crucial for muscle health and function.
• MRI data ...

Takeaways:

• The MAHA report aims to address public health issues but lacks actionable policies.
• Historical context is crucial for understanding current dietary guidelines.
• Funding for nutrition research has been inadequate, impacting the quality of data.
• Public perception of nutrition often outpaces scientific evidence.
• The evolution of dietary guidelines reflects political and social influences.
• There is a need for more rigorous nutr...