Docs Who Lift

Takeaways

• The book aims to dispel myths surrounding the Biggest Loser study.
• Miscommunication in media has led to public confusion about metabolism.
• Metabolic adaptation is a response to weight loss, not a determinant of it.
• Cultural factors significantly influence eating habits and food choices.
• The food environment plays a crucial role in dietary behaviors.
• Bipartisan support is necessary for effective food policy changes.
• Understan...

Takeaways

Menopausal women often prioritize weight gain concerns over other symptoms.

The study observed an association between hormone therapy and weight loss with GLP-1 medications.

Retrospective studies have limitations but can provide valuable insights.

Future research should focus on randomized controlled trials to confirm findings.

The relationship between estrogen and GLP-1 signaling needs further exploration.

Funding for researc...

Takeaways

• The podcast features Dr. Grant Tinsley, a body composition expert.
• The discussion revolves around a case series on body composition effects.
• GLP-1 receptor agonists are a focus of the research.
• The importance of resistance training in weight loss is emphasized.
• Patient case studies provide insights into individual experiences.
• The first patient lost a significant amount of fat mass while preserving lean mass.
• The second pati...

Takeaways

Direct-to-consumer lab testing is on the rise, with significant marketing efforts behind it.

Many patients feel brushed off by traditional healthcare providers, leading them to seek alternative testing options.

Communication between patients and healthcare providers is often inadequate, contributing to misunderstandings about health.

Over-testing can lead to unnecessary anxiety and misinterpretation of results.

Fitness influen...

In this episode of the Dr. Lift podcast, hosts Dr. Spencer Nadolsky and Dr. Karl discuss the recent changes in obesity medication coverage, particularly focusing on the CVS Caremark decision to drop ZEPBound from their formulary in favor of Wegovi. They explore the implications of this decision for patients and providers, the role of pharmacy benefit managers (PBMs) in healthcare, and the ongoing advocacy efforts to ensure access t...

In this episode of the Dr. Lift podcast, hosts Dr. Spencer Nadolsky and Dr. Karl discuss the Surpass CVOT trial, which evaluates the cardiovascular outcomes of Monjaro compared to Dulaglutide (Trulicity). They delve into the significance of the trial, the implications of the results, and the potential benefits of Monjaro for patients with type 2 diabetes and cardiovascular risks. The conversation highlights the importance of unders...

How the STEP-UP trial came to life,  and what made the 7.2mg dose possible

What the data actually says about weight loss and side effects at higher doses

Why trial design, pharmacokinetics, and estimands matter more than you think

What’s coming next in obesity meds: duals, triples, and even antagonists

The real talk on intermittent fasting, access issues, and preaching vs. science

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Takeaways

• The study examines the overlap between clinical and anthropometric obesity.
• Anthropometric measures include waist circumference, waist-to-hip ratio, and BMI.
• Challenges exist in applying the Lancet Commission's definitions in clinical practice.
• Metabolically healthy obesity is a debated topic in obesity research.
• The study highlights the importance of data from the All of Us Research Program.
• There is a significant prevalen...

Learn what age-related macular degeneration (AMD) is

What causes AMD

The types of AMD

The update on NAION - listen to last year's podcast all about it

Why we aren't too concerned

Click here to join Dr. Spencer's online clinic Vineyard

Click to read the JAMA AMD article

Click to read the Ophthalmology journal AMD article

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• Menopausal hormonal therapy should not be a blanket recommendation for everyone going through menopause
• Weight management in women is influenced by hormonal changes throughout life stages.
• Retrospective analyses can provide insights but have limitations.
• The wellness industry often oversimplifies complex medical issues.
• Hormonal replacement therapy may have subtle benefits for weight management.
• Confounding factors like SSRIs can co...

• Dr. Grant Tinsley joins the discussion as the body composition expert.
• Myostatin is a key regulator of muscle growth.
• Wendy Whippete the most jacked muscled up dog
• The concern of GLP-1 receptor agonists and muscle mass loss.
• Overview of Courage trial looking at semaglutide and trevogrumab and lean mass loss
• Upcoming Believe trial coming out (bimagrumab and semaglutide)
• Exercise remains crucial for muscle health and function.
• MRI data ...

Takeaways:

• The MAHA report aims to address public health issues but lacks actionable policies.
• Historical context is crucial for understanding current dietary guidelines.
• Funding for nutrition research has been inadequate, impacting the quality of data.
• Public perception of nutrition often outpaces scientific evidence.
• The evolution of dietary guidelines reflects political and social influences.
• There is a need for more rigorous nutr...

Click to read Joy Prescriptions

Drs. Karl and Spencer talk to Dr. Tiffany Moon all about Joy Prescriptions. Learn how to stop chasing perfection and embrace connection. 

00:00Introduction to Dr. Tiffany Moon

02:02Journey to Reality TV: The Real Housewives of Dallas

05:58Life After Reality TV: Finding Joy and Purpose

09:59The Joy Prescription: A New Approach to Life

17:01Work-Life Integration: Balancing Career and Family

22:09Empowering Wo...

• Tirzepatide is more effective for weight loss than semaglutide.
• Cost-effectiveness is crucial in prescribing weight loss medications.
• Patients with severe obesity should receive more expensive medications for better outcomes.
• Both medications show significant benefits for obesity-related conditions.
• Long-term studies indicate sustained weight loss with both drugs.
• Gender differences affect weight loss outcomes with these medications...

Takeaways

• MASH is a significant obesity-related complication.
• Semaglutide shows promise in treating MASH.
• Weight loss is crucial for improving liver health.
• Bariatric surgery remains the most effective treatment.
• The Essence trial indicates a 63% resolution of NASH.
• New medications are being developed for obesity treatment.
• Early intervention is key to preventing severe liver damage.
• Accessibility of medications is a major concern.
• Comp...