Regenerative Health with Max Gulhane, MD

In this conversation we unpack why chronic disease is not an inevitability but a consequence of the conditions modern life has created — and why the medical system is structurally incentivised to treat rather than cure. 

We get into the metabolic envelope, the evolutionary framework that defines what your biology was actually designed for, and why the circadian rhythm is the most foundational input in the whole system.&nb...

I speak with Johnathan Jarecki, undergraduate science student and host of The Signal Podcast, on all things photobiology. We discuss the full solar spectrum and how ultraviolet, visible, blue, red and near-infrared light each affect human physiology, including the POMC pathway, nitric oxide and blood pressure, and the evidence on sunlight, skin cancer and the vitamin D paradox. 

We also discuss how artificial light at night sup...

This is a practical conversation on circadian living — how to structure your day around light, darkness, food, movement and sleep in a way that supports your biology. 

We also explore the modern mismatch of indoor LED lighting, artificial light at night, late eating, phone use before bed, blue blockers, beeswax candles, incandescent light, night driving, flicker, skin cancer nuance, sun exposure, DHA, omega-3s and...

In this presentation I explore the relationship between Bitcoin, time preference, chronic disease, epigenetics, circadian biology, and preventative healthcare. I discuss

- Why modern healthcare is fundamentally reactive
- The relationship between low time preference thinking and long-term health
- Visceral fat, insulin resistance and metabolic disease
- How environmental mismatch impacts mitochondrial function
- ...

Birth, pregnancy and fertility are profoundly circadian processes — yet almost nobody talks about the role of light in maternal and infant health.

In this episode, I speak with Nikko Kennedy about melatonin, sunlight, vitamin D, labour physiology, EMF exposure and how modern environments may be disrupting pregnancy and birth. A fascinating discussion on circadian biology, photobiology and reproductive health.

 TIMESTAMPS

Dr Alexander Wunsch returns to the Regenerative Health Podcast for a deep exploration of photoimmunology, circadian biology, metabolism, melanopsin signalling, infrared light, and the profound biological effects of the modern light environment.

In this conversation we discuss:

• Whether sunlight is immune suppressive or immune supportive
• The circadian timing of immune function
• The relationship between metabolism and light exposure
• Mel...

In our follow up episode with Melanie Jackson, PhD of the Great Birth Rebellion, we discussed how full spectrum sunlight from UV to NIR offers irreplaceable nutrients for optimal pregnancy and health. 

Show sponsors:

🚨 DAYLIGHT COMPUTER. Blue-light free computer that doesn't wreck your circadian rhythm. Now shipping around the world. Code DRMAX for $25 off.   https://buy.daylightcomputer.com/DRMAX

🥩 WOLKI FARM - Re...

I spoke with Melanie Jackson, PhD of the Great Birth Rebellion on how circadian rhythms regulate key facets of reproductive health for women. We cover the basics of physiology then actionable steps for women and families. 

This conversation is essential listening if you are interested in understanding your body and improving your short and long term health. 

🚨 DAYLIGHT COMPUTER. Blue-light free computer that doesn't wreck ...

We explore how light shaped life from an evolutionary perspective — from the great oxygenation event and mitochondrial endosymbiosis to modern understandings of role of ultraviolet light in health.

Dr. Alexander Wunsch, MD, PhD is a German physician, researcher and one of the world’s leading experts in photobiology and light medicine.

SUPPORT MY WORK

🚨 DAYLIGHT COMPUTER. Blue-light free computer th...

Astrophysicist Robert Fosbury joins Dr Max Gulhane to explore an extraordinary idea: that the dominant photon energy of our Sun closely matches the metabolic activation energy that powers life on Earth.

We discuss:
• How stars generate order by exporting entropy as light
• Why living systems mirror stellar thermodynamics
• The 0.66 electron volt “control barrier” shared across biology
• The 10²¹ scali...

Modern humans are living in an environment radically different from the one our biology evolved to operate within. In this conversation, we explore how light, mitochondria, evolution, and physics shape aging, disease, mental health, and longevity. This episode reframes health not as a matter of isolated interventions, but as the consequence of whether we remain inside—or drift outside—the human biological envelope.
<...

We discuss three pivotal studies showing how natural light wavelengths positively influence health from all-cause mortality to visual perfomance to blood glucose control in Type II diabetics.

Jonathan Jarecki is a biomedical science sophomore with an interest in light and health, and host of Whole Health Podcast. 

SUPPORT MY WORK

🚨 DAYLIGHT COMPUTER. Blue-light free computer that doesn't wreck your circad...

Peter Cowan and I discuss the surge in non-contact soft-tissue injuries of 49ers players and possible mechanisms including chronic magnetic field exposure from nearby electrical substation, circadian rhythm disruption causing mitochondrial dysfunction, impaired collagen repair and delayed healing.

Peter Cowan is a software developer, health coach with an interest in applied circadian biology and EMF mitigating consultant.&nb...

Sunlight or fake light? We explore how light timing and intensity shape the circadian clock, mood, hormones, fertility, and sleep—and why amplitude is the missing key. Sean Kane shares new research on individual light sensitivity, depression and bipolar patterns, and practical fixes that work.

Sean Cain, PhD is a Matthew Flinders professor of circadian biology at Flinders University, Australia. He has more than 25 year...

In this talk I present the case that artificial light and wireless RF radiation are pervasive indoor pollutants that are disrupting your circadian rhythm and damaging the health of your children. 

Watch on Youtube to see the slides. 

CONSULT DR MAX
Initial consult - https://www.drmaxgulhane.com/offers/5jfDvLyH/checkout

SUPPORT MY WORK

🚨 DAYLIGHT COMPUTER. Blue-light free computer that doesn't wreck your ci...

We dig into why visceral fat drives disease risk, how to spot it on sight and imaging, and the levers that shrink it without losing muscle. We map a practical plan across food, fasting, light, stress, and training, and weigh GLP-1s and surgery against lifestyle-first care.

Christopher J. Stadtherr, MD is a board-certified physician in Family Medicine and Obesity Medicine, with expertise in nutrition and metabolic health. &nb...

Expert physician researcher Sunil Wimalawansa explains why Vitamin D plays a critical role in immune system function, the physiology various forms of vitamin D and how to ensure you keep a level compatible with optimal health.

Dr Sunil J. Wimalawansa, MD, PhD is a globally respected clinician-scientist, educator, over three decades of leadership in endocrinology, osteoporosis, metabolic bone disease, and nutrition. He served...

Repost of Guy Foundation 2025 Autumn Series Roundtable discussion "Improving our light environment for better health" on 3.12.25. 

The topic of my talk was "Metabolic consequences of indoor light environment".

Head to Guy Foundation YouTube channel to watch the talks with associated slides. Other speakers Biographies

• Professor Stefan Behling is Head of Studio, member of the Design Board and was responsible for Integrated desi...

Dr Ankur Vermur sees heart attack patients daily in his emergency room in New Delhi, India, almost all of them with normal cholesterol levels. We discuss the key, underappreciated metabolic risk factors for aetherosclerosis (ASCVD) and how you can avoid them with lifestyle changes.

SUPPORT MY WORK

🥩 WOLKI FARM. Highest quality fully grassfed & pastured pork, beef, lamb & eggs raised with holistic principles a...