New Data Reveals US Cities With Most Drug Users

By Jason Hall

April 14, 2025

USA Map
Photo: Getty Images

New data released by American Addiction Centers this month revealed the U.S. cities with the most drug users.

The study revealed that Phoenix, Arizona, had the highest percentage of population who had used cocaine (23.3%) and methamphetamine (15.1%); Omaha, Nebraska, had the highest percentage of population who had used heroin (3.4%) and marijuana (66.2%), as well as overall drug usage. The data released by the American Addiction Centers is included below:

Top 10 Cities with the Most Marijuana Use in the United States

  • Omaha, NE- 66.2%
  • Mesa, AZ- 65.0%
  • Tulsa, OK- 64.9%
  • Minneapolis, MN- 64.8%
  • Indianapolis, IN- 64.6%
  • Phoenix, AZ- 64.4%
  • Wichita, KS- 64.4%
  • Portland, OR- 64.2%
  • Nashville, TN- 64.2%
  • Oklahoma City, OK- 64.1%

Top 10 Cities with the Most Cocaine Use in the United States

  • Phoenix, AZ- 23.3%
  • Mesa, AZ- 22.5%
  • Omaha, NE- 22.2%
  • Oklahoma City, OK- 22.0%
  • Las Vegas, NV- 21.9%
  • Tulsa, OK- 21.8%
  • Wichita, KS- 21.8%
  • Colorado Springs, CO- 21.8%
  • Tucson, AZ- 21.8%
  • Fresno, CA- 21.8%

Top 10 Cities with the Most Heroin Use in the United States

  • Omaha, NE- 3.4%
  • Indianapolis, IN- 3.4%
  • Columbus, OH- 3.3%
  • Nashville, TN- 3.2%
  • Oklahoma City, OK- 3.1%
  • Tulsa, OK- 3.1%
  • Minneapolis, MN- 3.1%
  • Kansas City, MO- 3.1%
  • Memphis, TN- 3.1%
  • Wichita, KS- 3.0%

Top 10 Cities with the Most Methamphetamine Use in the United States

  • Phoenix, AZ- 15.1%
  • Mesa, AZ- 14.1%
  • Omaha, NE- 14.0%
  • Oklahoma City, OK- 13.8%
  • Fresno, CA- 13.8%
  • Las Vegas, NV- 13.5%
  • Tulsa, OK- 13.4%
  • Wichita, KS- 13.4%
  • Arlington, TX- 13.4%
  • Tucson, AZ- 13.4%

Top 10 Cities with the Most Methamphetamine Use in the United States (listed alphabetically)

  • Colorado Springs, CO
  • Indianapolis, IN
  • Las Vegas, NV
  • Mesa, AZ
  • Minneapolis, MN
  • Oklahoma City, OK
  • Omaha, NE
  • Phoenix, AZ
  • Tulsa, OK
  • Wichita, KS

The full data can be found on American Addiction Centers' website.

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