The Joe Cohen Show

In this episode, Joe has an in-depth conversation with Dr. Rita Marie, a licensed doctor of chiropractic and the founder of the Institute of Nutritional Endocrinology, about the importance of personalized healthcare in addressing insulin, thyroid, adrenal, and digestive imbalances through the integration of genetics and lifestyle changes. 

Dr. Rita Marie discusses her approach to helping patients by not only looking at conventional...

In this episode, Joe dives deep into the effects of megadosing AKG (Alpha Ketoglutarate), a crucial supplement in metabolic pathways and its implications for longevity. Discover the risks and rewards as Joe recounts increasing his AKG intake to 15 times the standard dosage, leading to notable side effects such as enhanced anxiety and sleep issues. 

Joe meticulously explains the biochemical transformation of AKG into glutamate and r...

In this episode, we delve into the pivotal role of the BHMT gene within the body's methylation process. 

We discuss how the BHMT enzyme is essential for catalyzing a vital reaction that transforms homocysteine into methionine. 

Additionally, we cover the importance of betaine in enhancing the methylation cycle. Betaine acts as a methyl donor, particularly in the reaction facilitated by the BHMT enzyme, making it crucial for red...

In this episode, Joe tackles a controversial new study that suggests even 25 milligrams of niacin could potentially increase the risk of heart disease. 

Delving deep into the world of niacin supplementation, Joe discusses how, despite these concerns, niacin offers numerous health benefits, including enhanced cognitive function, better mood, and increased energy levels.

Joe draws on personal experiences to compare the negatives agai...

In this episode, we explore the complex interplay between the CNR1 gene, cannabinoid receptors, and cannabis. 

Discover the role of the endocannabinoid system in maintaining bodily balance, particularly in brain function, mood regulation, and inflammation response. 

We delve deep into how genetic variations in the CNR1 gene can influence the CB1 receptors, and the implications of CB1 receptor function in managing stress, anxiety, a...

In this episode, we explore the crucial role of serotonin in managing anxiety and enhancing mental wellbeing. 

Discover how serotonin not only influences mood but also plays a pivotal role in anxiety regulation and mental health. 

Learn about the HTR1A and HTR2A genes, which act like switches, controlling the serotonin levels in the brain. 

Understanding the SNPs in these genes can provide personal insights into your serotonin acti...

In this episode, Joe takes questions from SelfDecode members, answering questions like:

• What makes SelfDecode different from other DNA companies?

• How does the recommendations engine work?

• Can you find out if a certain supplement is right for you?

Plus, he shares some of his genetic predispositions and how they correlate with his lab levels!

- Check out SelfDecode: https://selfdecode.com/

- Join Joe’s online commun...

In this episode, we delve into the critical process of methylation, highlighting its significant impact on health issues ranging from heart disease to mental health and focusing on a lesser known methylation gene - MTHFD1.

We focus on the MTHFD1 gene and choline's significance beyond methylfolate and Vitamin B12 for undermethylators. 

Discover how MTHFD1 impacts methylation by metabolizing tetrahydrofolate and how choline is im...

This episode was originally published on April 12, 2015.

Dr. Jack Kruse and Joe explore unconventional approaches to health through the lens of physics and biochemistry. 

They cover topics like the critical roles of mitochondrial function, environmental factors such as EMFs, blue light, and dietary choices on our well-being, and challenge common health paradigms, emphasizing the importance of circadian biology, the effects of cold ...

In this episode, we delve into the science behind the MAOB gene and monoamine neurotransmitters. 

Join us as we explore the crucial role of dopamine, serotonin, and norepinephrine in regulating mood and cognition. 

We dissect the function of the MAOB gene in metabolizing neurotransmitters and discuss the implications of genetic variations on mental health. 

From increased breakdown linked to mood disorders to decreased activity ass...

In this episode, Joe dives into the world of personalized wellness with Lauren Sambataro and Renee Belz, known as The Biohacker Babes.

With roots in wellness and holistic dentistry, The Biohacker Babes bring their wealth of expertise as health entrepreneurs, nutritional consultants, and holistic lifestyle coaches to the table.

In this enlightening conversation, we explore the pivotal role of lab testing in crafting personalized hea...

In this episode of The Joe Cohen Show, we dive deep into the world of dopamine.

We'll be focusing on the role of genetics, specifically the DRD2 gene, in regulating dopamine levels and how it affects your brain's reward system, motivation, and susceptibility to addiction.

Here's what you can expect to learn:

• How the DRD2 gene influences dopamine D2 receptors and their impact on pleasure-seeking behaviors.

• Unders...

Join us for an enlightening roundtable discussion featuring health experts Joe Cohen, Kris Gethin, Tim Gray, and Siim Land as they dive deep into the world of health optimization. 

In this episode, our expert panel explores a wide range of health tests and biomarkers, from basic to advanced, and what they mean for your health, including VO2 max assessments, heart rate variability, full-body MRI scans, gut microbiome analysis, and f...

Love is in the air as we dive into the science behind relationships.

In this episode, we explore the fascinating world of oxytocin, affectionately known as the "love hormone," and its connection to the OXTR gene.

Responsible for encoding the oxytocin receptor, this gene plays a crucial role in shaping our social bonds, empathy levels, and even cognitive abilities. We discuss groundbreaking research, including the 'hap...

In this episode, Joe discusses skin health, anti-aging strategies, and the science behind skincare with biohacker and beauty industry leader Amitay Eshel, CEO of Young Goose. 

Amitay shares his expertise on improving skin health through a combination of internal health, high-quality skincare products, and biohacking techniques. 

The conversation covers topics such as the efficacy of various skincare ingredients, the impact of sun e...

In this episode, we uncover the significance of the CLOCK and PER2 genes, pivotal players in regulating your body's circadian rhythm. Learn how these genes influence your sleep patterns, alertness levels, and even your predisposition to certain health conditions.

Discover how variants in the CLOCK gene can impact your circadian rhythm, sleep duration, and daily activity patterns. 

Explore the associations between genetic variat...

In this episode, Joe brings on Dr. Ben Lynch - renowned geneticist and author of Dirty Genes - to unreavel the science of methylation, MTHFR, folates, and homocysteine.

Dr. Lynch intricately unpacks the complexities of methylation pathways, shedding light on how genetic variations can impact these crucial processes. 

Joe and Ben then delve into the specifics of homocysteine metabolism and the role of B vitamins in maintaining optim...

In this episode of SNPit, we delve into the fascinating world of the FOXO3 gene, a genetic guardian that holds the key to a longer life. 

But here's the twist: did you know that certain variants of this gene could impact your lifespan more than smoking a pack of cigarettes every day for 25 years? 

We uncover the research behind this startling revelation and discuss the implications for our health and well-being. 

Plus, we revea...

Joe delves deep into the world of biohacking alongside esteemed naturopath Michael Smith. 

Drawing on two decades of expertise, Michael shares invaluable insights into optimizing health, particularly focusing on gut health and the microbiome. 

From his personal journey to professional practice, Michael discusses the latest advancements in gut health research, tackling issues such as fatigue, autoimmune conditions, and more.

Michael...