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June 11, 2025 7 mins

Story at-a-glance

  • People managing multiple chronic illnesses are nearly twice as likely to develop depression, even if they’ve never had mental health issues before, according to a decade-long study
  • Living with both heart disease and diabetes drastically increases your future depression risk, making cardiometabolic combinations among the most dangerous for emotional health outcomes
  • Chronic illnesses like asthma, chronic obstructive pulmonary disease (COPD), liver disease, and bowel disorders sharply increase your risk of depression by overwhelming your body’s ability to regulate mood and energy
  • Women with joint and bone issues like arthritis face a higher depression risk than men with the same diagnosis, revealing a serious and often ignored gender vulnerability
  • Depression doesn’t just follow disease — it drives it. Left untreated, it speeds up illness progression, weakens your immune system, and increases your chances of hospitalization
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