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June 10, 2025 8 mins

Story at-a-glance

  • Your skin microbiome helps protect against UV radiation damage by metabolizing harmful cis-urocanic acid (cis-UCA) using an enzyme called urocanase, preventing immunosuppression and inflammation after sun exposure
  • Urocanase-positive bacteria rapidly respond to UVB exposure, shifting skin microbiome composition within hours and creating a protective feedback loop that supports overall skin health
  • Conventional sunscreens often disrupt beneficial skin bacteria, while certain microbes produce protective compounds like pigments, antioxidants, and enzymes that naturally neutralize harmful UV radiation
  • Linoleic acid (LA) from vegetable oils accumulates in skin cells, making them vulnerable to UV damage. Conversely, C15:0 fat can eventually replace LA in cell membranes
  • Reducing LA intake and supplementing with 2 grams of C15:0 daily can help boost skin health in 12 to 18 months, enabling greater sun resilience without relying on conventional sunscreens
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